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. 1991 Dec;66(12):1378–1382. doi: 10.1136/adc.66.12.1378

IgG subclass specific antibody response in recurrent bronchitis.

F de Baets 1, R Pauwels 1, I Schramme 1, J Leroy 1
PMCID: PMC1793374  PMID: 1776880

Abstract

The IgG subclass specific immune response against pneumococcal type 3 polysaccharide antigen before and after immunisation in healthy children and children with recurrent bronchitis was studied. Recurrent bronchitis was defined as three or more episodes a year, during at least two consecutive years, of bronchopulmonary infection, productive cough with or without fever, and/or diffuse rales by physical examination. Twenty five patients and 15 healthy children were selected. The patient group had lower concentrations of IgG1 and IgG2 specific pneumococcal antibodies compared with healthy children, regardless of whether or not the total IgG2 concentration was low. The children with recurrent bronchitis showed a greater increase in IgG1 and IgG2 antibodies after immunisation than the controls. It is concluded that children with recurrent bronchitis show a decreased humoral immune response to pneumococcal type 3 polysaccharide antigen. This finding suggests that a defect in the humoral immune response against polysaccharide antigens is an important cause of recurrent bronchitis in childhood.

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Selected References

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  1. Ambrosino D. M., Schiffman G., Gotschlich E. C., Schur P. H., Rosenberg G. A., DeLange G. G., van Loghem E., Siber G. R. Correlation between G2m(n) immunoglobulin allotype and human antibody response and susceptibility to polysaccharide encapsulated bacteria. J Clin Invest. 1985 Jun;75(6):1935–1942. doi: 10.1172/JCI111909. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ambrosino D. M., Siber G. R., Chilmonczyk B. A., Jernberg J. B., Finberg R. W. An immunodeficiency characterized by impaired antibody responses to polysaccharides. N Engl J Med. 1987 Mar 26;316(13):790–793. doi: 10.1056/NEJM198703263161306. [DOI] [PubMed] [Google Scholar]
  3. Ambrosino D. M., Umetsu D. T., Siber G. R., Howie G., Goularte T. A., Michaels R., Martin P., Schur P. H., Noyes J., Schiffman G. Selective defect in the antibody response to Haemophilus influenzae type b in children with recurrent infections and normal serum IgG subclass levels. J Allergy Clin Immunol. 1988 Jun;81(6):1175–1179. doi: 10.1016/0091-6749(88)90887-1. [DOI] [PubMed] [Google Scholar]
  4. Barrett D. J., Ayoub E. M. IgG2 subclass restriction of antibody to pneumococcal polysaccharides. Clin Exp Immunol. 1986 Jan;63(1):127–134. [PMC free article] [PubMed] [Google Scholar]
  5. Buckley R. H., Dees S. C., O'Fallon W. M. Serum immunoglobulins. I. Levels in normal children and in uncomplicated childhood allergy. Pediatrics. 1968 Mar;41(3):600–611. [PubMed] [Google Scholar]
  6. Douglas R. M., Paton J. C., Duncan S. J., Hansman D. J. Antibody response to pneumococcal vaccination in children younger than five years of age. J Infect Dis. 1983 Jul;148(1):131–137. doi: 10.1093/infdis/148.1.131. [DOI] [PubMed] [Google Scholar]
  7. Euler A. R., Ament M. E. Detection of gastroesophageal reflux in the pediatric-age patient by esophageal intraluminal pH probe measurement (Tuttle test). Pediatrics. 1977 Jul;60(1):65–68. [PubMed] [Google Scholar]
  8. Freijd A., Hammarström L., Persson M. A., Smith C. I. Plasma anti-pneumococcal antibody activity of the IgG class and subclasses in otitis prone children. Clin Exp Immunol. 1984 May;56(2):233–238. [PMC free article] [PubMed] [Google Scholar]
  9. GIBSON L. E., COOKE R. E. A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis. Pediatrics. 1959 Mar;23(3):545–549. [PubMed] [Google Scholar]
  10. Gergen P. J., Mullally D. I., Evans R., 3rd National survey of prevalence of asthma among children in the United States, 1976 to 1980. Pediatrics. 1988 Jan;81(1):1–7. [PubMed] [Google Scholar]
  11. Kjellman N. M., Johansson S. G., Roth A. Serum IgE levels in healthy children quantified by a sandwich technique (PRIST). Clin Allergy. 1976 Jan;6(1):51–59. doi: 10.1111/j.1365-2222.1976.tb01411.x. [DOI] [PubMed] [Google Scholar]
  12. Knutsen A. P. Patients with Igg subclass and/or selective antibody deficiency to polysaccharide antigens: initiation of a controlled clinical trial of intravenous immune globulin. J Allergy Clin Immunol. 1989 Oct;84(4 Pt 2):640–647. doi: 10.1016/0091-6749(89)90203-0. [DOI] [PubMed] [Google Scholar]
  13. Noyes J., Woodmansee D., Chervinsky P. IgG subtype abnormalities with normal total IgG in a clinical allergy practice. Ann Allergy. 1986 Oct;57(4):273–275. [PubMed] [Google Scholar]
  14. Paton J. C., Toogood I. R., Cockington R. A., Hansman D. Antibody response to pneumococcal vaccine in children aged 5 to 15 years. Am J Dis Child. 1986 Feb;140(2):135–138. doi: 10.1001/archpedi.1986.02140160053031. [DOI] [PubMed] [Google Scholar]
  15. Riesen W. F., Skvaril F., Braun D. G. Natural infection of man with group A streptococci. Levels; restriction in class, subclass, and type; and clonal appearance of polysaccharide-group-specific antibodies. Scand J Immunol. 1976;5(4):383–390. doi: 10.1111/j.1365-3083.1976.tb00292.x. [DOI] [PubMed] [Google Scholar]
  16. Schatz D. A., Barrett D. J. Evolution of the subclass of IgG antibody to type 3 pneumococcal polysaccharide during childhood. Clin Exp Immunol. 1987 Nov;70(2):449–455. [PMC free article] [PubMed] [Google Scholar]
  17. Schur P. H., Borel H., Gelfand E. W., Alper C. A., Rosen F. S. Selective gamma-g globulin deficiencies in patients with recurrent pyogenic infections. N Engl J Med. 1970 Sep 17;283(12):631–634. doi: 10.1056/NEJM197009172831205. [DOI] [PubMed] [Google Scholar]
  18. Shackelford P. G., Granoff D. M., Madassery J. V., Scott M. G., Nahm M. H. Clinical and immunologic characteristics of healthy children with subnormal serum concentrations of IgG2. Pediatr Res. 1990 Jan;27(1):16–21. doi: 10.1203/00006450-199001000-00004. [DOI] [PubMed] [Google Scholar]
  19. Shackelford P. G., Granoff D. M., Polmar S. H., Scott M. G., Goskowicz M. C., Madassery J. V., Nahm M. H. Subnormal serum concentrations of IgG2 in children with frequent infections associated with varied patterns of immunologic dysfunction. J Pediatr. 1990 Apr;116(4):529–538. doi: 10.1016/s0022-3476(05)81598-7. [DOI] [PubMed] [Google Scholar]
  20. Shackelford P. G., Polmar S. H., Mayus J. L., Johnson W. L., Corry J. M., Nahm M. H. Spectrum of IgG2 subclass deficiency in children with recurrent infections: prospective study. J Pediatr. 1986 May;108(5 Pt 1):647–653. doi: 10.1016/s0022-3476(86)81035-6. [DOI] [PubMed] [Google Scholar]
  21. Siber G. R., Schur P. H., Aisenberg A. C., Weitzman S. A., Schiffman G. Correlation between serum IgG-2 concentrations and the antibody response to bacterial polysaccharide antigens. N Engl J Med. 1980 Jul 24;303(4):178–182. doi: 10.1056/NEJM198007243030402. [DOI] [PubMed] [Google Scholar]
  22. Smith T. F., Ireland T. A., Zaatari G. S., Gay B. B., Zwiren G. T., Andrews H. G. Characteristics of children with endoscopically proved chronic bronchitis. Am J Dis Child. 1985 Oct;139(10):1039–1044. doi: 10.1001/archpedi.1985.02140120085033. [DOI] [PubMed] [Google Scholar]
  23. Smith T. F., Morris E. C., Bain R. P. IgG subclasses in nonallergic children with chronic chest symptoms. J Pediatr. 1984 Dec;105(6):896–900. doi: 10.1016/s0022-3476(84)80073-6. [DOI] [PubMed] [Google Scholar]
  24. Stanley P. J., Corbo G., Cole P. J. Serum IgG subclasses in chronic and recurrent respiratory infections. Clin Exp Immunol. 1984 Dec;58(3):703–708. [PMC free article] [PubMed] [Google Scholar]
  25. Umetsu D. T., Ambrosino D. M., Quinti I., Siber G. R., Geha R. S. Recurrent sinopulmonary infection and impaired antibody response to bacterial capsular polysaccharide antigen in children with selective IgG-subclass deficiency. N Engl J Med. 1985 Nov 14;313(20):1247–1251. doi: 10.1056/NEJM198511143132002. [DOI] [PubMed] [Google Scholar]
  26. Yount W. J., Dorner M. M., Kunkel H. G., Kabat E. A. Studies on human antibodies. VI. Selective variations in subgroup composition and genetic markers. J Exp Med. 1968 Mar 1;127(3):633–646. doi: 10.1084/jem.127.3.633. [DOI] [PMC free article] [PubMed] [Google Scholar]

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