Skip to main content
NCBI home page
The Journal of Hygiene logoLink to The Journal of Hygiene
. 1976 Apr;76(2):249–256. doi: 10.1017/s0022172400055145

Mouse or man? Which are pertussis vaccines to protect?

N W Preston, T N Stanbridge
PMCID: PMC2129630  PMID: 177701

Abstract

Type 1 strains of Bordetella pertussis can infect mouse brain and have been recovered as type 1 organisms after death. When introduced into the naso-pharynx of the marmoset, they immediately acquired agglutinogen 2 or 3, and the resulting type 1,2 or 1,3 infection persisted for many weeks. As in the child, agglutinogens 2 and/or 3 appear to be essential for infection of the marmoset, whereas they are quite unnecessary in mouse brain. A vaccine (extract or whole cell) containing agglutinogen 1 may be sufficient to pass the mouse protection test but it may fail to immunize children. The mouse test is inadequate even for the screening of such extracts.

Full text

PDF
249

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSEN E. K. Some observations made during experiments on mice inoculated with H. pertussis. Acta Pathol Microbiol Scand. 1952;31(4):546–560. doi: 10.1111/j.1699-0463.1952.tb00222.x. [DOI] [PubMed] [Google Scholar]
  2. Cameron J. Variation in Bordetella pertussis. J Pathol Bacteriol. 1967 Oct;94(2):367–374. doi: 10.1002/path.1700940216. [DOI] [PubMed] [Google Scholar]
  3. Dolby J. M., Bronne-Shanbury C. J. The use of spheroplast-derived strains to differentiate between Bordetella pertussis heat-labile agglutinogens and protective antigen for mice. J Biol Stand. 1975;3(1):89–100. doi: 10.1016/0092-1157(75)90011-6. [DOI] [PubMed] [Google Scholar]
  4. Dolby J. M., Stephens S. Pertussis antibodies in the sera of children exposed to Bordetella pertussis by vaccination or infection. J Hyg (Lond) 1973 Mar;71(1):193–207. doi: 10.1017/s0022172400046362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Eldering G., Holwerda J., Baker J. Bordetella pertussis culture having only species factor 1. J Bacteriol. 1966 May;91(5):1759–1762. doi: 10.1128/jb.91.5.1759-1762.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kendrick P. L., Eldering G., Dixon M. K., Misner J. Mouse Protection Tests in the Study of Pertussis Vaccine: A Comparative Series Using the Intracerebral Route for Challenge. Am J Public Health Nations Health. 1947 Jul;37(7):803–810. [PMC free article] [PubMed] [Google Scholar]
  7. Nakase Y., Takatsu K., Kasuga T. Antigenic structure and phase variation in Bordetella pertussis. Jpn J Microbiol. 1969 Sep;13(3):283–291. doi: 10.1111/j.1348-0421.1969.tb00468.x. [DOI] [PubMed] [Google Scholar]
  8. PILLEMER L., BLUM L., LEPOW I. H. Protective antigen of haemophilus pertussis. Lancet. 1954 Jun 19;266(6825):1257–1260. doi: 10.1016/s0140-6736(54)92770-1. [DOI] [PubMed] [Google Scholar]
  9. PRESTON N. W., EVANS P. Type-specific immunity against intracerebral pertussis infection in mice. Nature. 1963 Feb 2;197:508–509. doi: 10.1038/197508a0. [DOI] [PubMed] [Google Scholar]
  10. PRESTON N. W., TE PUNGA W. A. The relation between agglutinin production by pertussis vaccines and their immunising potency in mice. J Pathol Bacteriol. 1959 Jul;78:209–216. doi: 10.1002/path.1700780123. [DOI] [PubMed] [Google Scholar]
  11. Perkins F. T. Vaccination against whooping-cough. Br Med J. 1969 Nov 15;4(5680):429–430. doi: 10.1136/bmj.4.5680.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Preston N. W. Potency tests for pertussis vaccines: doubtful value of intracerebral challenge test in mice. J Pathol Bacteriol. 1966 Jan;91(1):173–179. doi: 10.1002/path.1700910121. [DOI] [PubMed] [Google Scholar]
  13. Preston N. W., Stanbridge T. N. Efficacy of pertussis vaccines: a brighter horizon. Br Med J. 1972 Aug 19;3(5824):448–451. doi: 10.1136/bmj.3.5824.448. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Preston N. W. Vaccine composition in relation to antigenic variation of the microbe: is pertussis unique? Prog Drug Res. 1975;19:347–355. doi: 10.1007/978-3-0348-7090-0_40. [DOI] [PubMed] [Google Scholar]
  15. Preston N. W. What makes a good pertussis vaccine? Prog Drug Res. 1975;19:341–346. doi: 10.1007/978-3-0348-7090-0_39. [DOI] [PubMed] [Google Scholar]
  16. Ross R. F., Munoz J. Antigens of Bordetella pertussis V. Separation of Agglutinogen 1 and Mouse-Protective Antigen. Infect Immun. 1971 Feb;3(2):243–248. doi: 10.1128/iai.3.2.243-248.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. STANDFAST A. F. Some factors influencing the virulence for mice of Bordetella pertussis by the intracerebral route. Immunology. 1958 Apr;1(2):123–134. [PMC free article] [PubMed] [Google Scholar]
  18. Stanbridge T. N., Preston N. W. Experimental pertussis infection in the marmoset: type specificity of active immunity. J Hyg (Lond) 1974 Apr;72(2):213–228. doi: 10.1017/s0022172400023421. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Stanbridge T. N., Preston N. W. Variation of serotype in strains of Bordetella pertussis. J Hyg (Lond) 1974 Oct;73(2):305–310. doi: 10.1017/s0022172400024165. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Hygiene are provided here courtesy of Cambridge University Press

RESOURCES