Abstract
We have previously reported that uridine monophosphate kinase (UMPK) is genetically polymorphic in man, and that the UMPK2 gene product has less activity than that of UMPK1 when measured in normal red cells. In this paper we present evidence that the activity of UMPK, like that of many other enzymes, declines during red cell aging, and that the lower activity of UMPK 2, as compared with UMPK 1, is best explained by its more rapid catabolism.
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- Bartos H. R., Desforges J. F. Enzymes as erythrocyte age reference standards. Am J Med Sci. 1967 Dec;254(6):862–865. doi: 10.1097/00000441-196712000-00015. [DOI] [PubMed] [Google Scholar]
- Chen S. H., Malcolm L. A., Yoshida A., Giblett E. R. Phosphoglycerate kinase: an X-linked polymorphism in man. Am J Hum Genet. 1971 Jan;23(1):87–91. [PMC free article] [PubMed] [Google Scholar]
- Giblett E. R., Anderson J. E., Chen S. H., Teng Y. S., Cohen F. Uridine monophosphate kinase: A new genetic polymorphism with possible clinical implications. Am J Hum Genet. 1974 Sep;26(5):627–635. [PMC free article] [PubMed] [Google Scholar]
- Koerner J. F. Enzymes of nucleic acid metabolism. Annu Rev Biochem. 1970;39:291–322. doi: 10.1146/annurev.bi.39.070170.001451. [DOI] [PubMed] [Google Scholar]
- Murphy J. R. Influence of temperature and method of centrifugation on the separation of erythrocytes. J Lab Clin Med. 1973 Aug;82(2):334–341. [PubMed] [Google Scholar]
- Piomelli S., Corash L. M., Davenport D. D., Miraglia J., Amorosi E. L. In vivo lability of glucose-6-phosphate dehydrogenase in GdA- and GdMediterranean deficiency. J Clin Invest. 1968 Apr;47(4):940–948. doi: 10.1172/JCI105786. [DOI] [PMC free article] [PubMed] [Google Scholar]