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. 1976 May;73(5):1679–1683. doi: 10.1073/pnas.73.5.1679

Cholera toxin interactions with thyrotropin receptors on thyroid plasma membranes.

B R Mullin, S M Aloj, P H Fishman, G Lee, L D Kohn, R O Brady
PMCID: PMC430363  PMID: 179095

Abstract

Unlabeled cholera toxin inhibits [125I]thyrotropin binding to thyrotropin receptors on thyroid plasma membranes. Maximal inhibition by cholera toxin does not exceed 40%, whereas unalbeled thyrotropin completely inhibits [125I]thyrotropin binding to these same membranes. Kinetic analyses of the binding data are compatible with the view that the cholera toxin decreases the number of receptor sites available to thyrotropin and that the mechanism by which the cholera toxin inhibits [125I]thyrotropin binding to these receptor sites involves both competitive and noncompetitive elements.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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