Skip to main content
NCBI home page
Gut logoLink to Gut
. 1972 Sep;13(9):709–712. doi: 10.1136/gut.13.9.709

Effect of cholecystokinin-pancreozymin and secretin on the volume, composition, and enzymatic activity of hepatic bile in rabbits

S Kirchmayer, A Tarnawski, H Drożdż, K Cichecka
PMCID: PMC1412371  PMID: 18668839

Abstract

In rabbits given cholecystokinin-pancreozymin intravenously a statistically significant increase in bile volume and alkaline phosphatase (AP) activity was observed. There was also an increase in the total amount of protein, cholesterol, bicarbonates Na, K, Ca, Mg, and the total activity of alkaline phosphatase and leucineaminopeptidase (LAP) secreted in bile within 90 minutes after pancreozymin injection. Pancreozymin had no effect on the concentration and output of taurocholates and the activity of gammaglutamyltranspeptidase (GGTP) and alanineaminotransferase (ALAT) in bile. Secretin neither changes the volume nor the concentration of any of the investigated components in rabbit bile.

Full text

PDF
709

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Boyer J. L., Klatskin G. Canalicular bile flow and bile secretory pressure. Evidence for a non-bile salt dependent fraction in the isolated perfused rat liver. Gastroenterology. 1970 Dec;59(6):853–859. [PubMed] [Google Scholar]
  2. Brooks F. P. The secretion of bile. Am J Dig Dis. 1969 May;14(5):343–349. doi: 10.1007/BF02235947. [DOI] [PubMed] [Google Scholar]
  3. CHIAMORI N., HENRY R. J. Study of the ferric chloride method for determination of total cholesterol and cholesterol esters. Am J Clin Pathol. 1959 Apr;31(4):305–309. doi: 10.1093/ajcp/31.4.305. [DOI] [PubMed] [Google Scholar]
  4. DAUGHADAY W. H., LOWRY O. H., ROSEBROUGH N. J., FIELDS W. S. Determination of cerebrospinal fluid protein with the Folin phenol reagent. J Lab Clin Med. 1952 Apr;39(4):663–665. [PubMed] [Google Scholar]
  5. GOLDBARG J. A., RUTENBURG A. M. The colorimetric determination of leucine aminopeptidase in urine and serum of normal subjects and patients with cancer and other diseases. Cancer. 1958 Mar-Apr;11(2):283–291. doi: 10.1002/1097-0142(195803/04)11:2<283::aid-cncr2820110209>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  6. Hardison W. G., Norman J. C. Electrolyte composition of the secretin fraction of bile from the perfused pig liver. Am J Physiol. 1968 Apr;214(4):758–763. doi: 10.1152/ajplegacy.1968.214.4.758. [DOI] [PubMed] [Google Scholar]
  7. JORPES J. E., MUTT V., JONSON G., THUL, SUNDMANLIN L. THE EFFECT OF SECRETIN ON BILE FLOW. Gastroenterology. 1963 Dec;45:786–788. [PubMed] [Google Scholar]
  8. Jones R. S., Grossman M. I. Choleretic effects of secretin and histamine in the dog. Am J Physiol. 1969 Aug;217(2):532–535. doi: 10.1152/ajplegacy.1969.217.2.532. [DOI] [PubMed] [Google Scholar]
  9. Konturek S. J., Dabrowski A., Adamczyk B., Kulpa J. The effect of secretin, gastrin-pentapeptide, and histamine on gastric acid and hepatic bile secretion in man. Am J Dig Dis. 1969 Dec;14(12):900–907. doi: 10.1007/BF02233211. [DOI] [PubMed] [Google Scholar]
  10. LeVEEN H. H., TALBOT L. J., RESTUCCIA M., BARBERIO J. R. Metabolism and excretion of alkaline phosphatase: relation to liver function and determination of maximal secretory rates of liver. J Lab Clin Med. 1950 Aug;36(2):192–205. [PubMed] [Google Scholar]
  11. ORLOWSKI M., SZEWCZUK A. Determination of gamma-glutamyl transpeptidase activity in human serum and urine. Clin Chim Acta. 1962 Nov;7:755–760. doi: 10.1016/0009-8981(62)90055-4. [DOI] [PubMed] [Google Scholar]
  12. PREISIG R., COOPER H. L., WHEELER H. O. The relationship between taurocholate secretion rate and bile production in the unanesthetized dog during cholinergic blockade and during secretin administration. J Clin Invest. 1962 May;41:1152–1162. doi: 10.1172/JCI104568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Waitman A. M., Dyck W. P., Janowitz H. D. Effect of secretin and acetazolamide on the volume and electrolyte composition of hepatic bile in man. Gastroenterology. 1969 Feb;56(2):286–294. [PubMed] [Google Scholar]
  14. Wheeler H. O., Mancusi-Ungaro P. L. Role of bile ducts during secretin choleresis in dogs. Am J Physiol. 1966 May;210(5):1153–1159. doi: 10.1152/ajplegacy.1966.210.5.1153. [DOI] [PubMed] [Google Scholar]
  15. Wheeler H. O., Ross E. D., Bradley S. E. Canalicular bile production in dogs. Am J Physiol. 1968 Apr;214(4):866–874. doi: 10.1152/ajplegacy.1968.214.4.866. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES