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. 1998 Sep;27(1-3):293–308. doi: 10.1023/A:1008058031511

Apoptosis resistance in tumor cells

Tetsuo Mashima 1, Hiroyuki Seimiya 2, Zhihong Chen 1, Shiro Kataoka 3, Takashi Tsuruo 1,4
PMCID: PMC3449558  PMID: 19002800

Abstract

Various antitumor agents induce apoptotic cell death in tumor cells. Since the apoptosis program in tumor cells plays a critical role in the chemotherapy-induced tumor cell killing, it is suggested that the defect in the signaling pathway of apoptosis could cause a new form of multidrug resistance in tumor cells. This article describes the recent findings concerning the mechanisms of chemotherapy-induced apoptosis and discusses the implication of apoptosis resistance in cancer chemotherapy.

Keywords: actin, apoptosis resistance, bcl-2, caspase, JNK, solid tumor

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