Abstract
The behavior of a transplanted adenocarcinoma of the uterus of a rabbit has been studied through 12 serial generations in the anterior chamber of the eye and 6 serial generations in the testicle. The transplanted tumor is characterized by slow growth which is at first expansive and later invasive, by an ability to form more or less differentiated structures in response to different environmental conditions and by late metastasis. The endocrinological changes that distinguish animals bearing the spontaneous tumor do not occur in animals bearing the transplanted tumor. Various experiments were undertaken in an attempt to discover the nature of the factors determining the characteristics of the spontaneous and of the transplanted tumor. It was found that successful transplantation was followed by a phase during which animals were refractory to reinoculation. The results of transplantation into the eyes of animals with spontaneous tumors suggested the existence of a similar phase during the early development of the tumor but the number of observations was not sufficiently numerous to warrant definite conclusions.
Full Text
The Full Text of this article is available as a PDF (1.3 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brown W. H., Pearce L. STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : I. THE SPONTANEOUS TUMOR AND ASSOCIATED ABNORMALITIES. J Exp Med. 1923 Apr 30;37(5):601–629. doi: 10.1084/jem.37.5.601. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greene H. S., Saxton J. A. UTERINE ADENOMATA IN THE RABBIT : I. CLINICAL HISTORY, PATHOLOGY AND PRELIMINARY TRANSPLANTATION EXPERIMENTS. J Exp Med. 1938 Apr 30;67(5):691–708. doi: 10.1084/jem.67.5.691. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pearce L., Brown W. H. STUDIES BASED ON A MALIGNANT TUMOR OF THE RABBIT : IV. THE RESULTS OF MISCELLANEOUS METHODS OF TRANSPLANTATION, WITH A DISCUSSION OF FACTORS INFLUENCING TRANSPLANTATION IN GENERAL. J Exp Med. 1923 May 31;37(6):811–828. doi: 10.1084/jem.37.6.811. [DOI] [PMC free article] [PubMed] [Google Scholar]