Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1991 Mar;63(3):460–462. doi: 10.1038/bjc.1991.107

Computed tomography (CT) and ultrasound (US) guided core biopsy in the management of non-Hodgkin's lymphoma.

J S Whelan 1, R H Reznek 1, S J Daniell 1, A J Norton 1, T A Lister 1, A Z Rohatiner 1
PMCID: PMC1971881  PMID: 2003989

Abstract

Histological examination of adequate biopsy specimens is fundamental to the management of patients with non-Hodgkin's lymphoma (NHL). A practical alternative to open biopsy, provided enough tissue can be obtained, has obvious advantages, especially if the lesion in question is deep seated, and might call for laparotomy or thoracotomy. Core biopsy with computed tomography (CT) or ultrasound (US) guidance may be such an alternative, particularly when a spring-loaded firing device is used. Thirty-four biopsies were performed in 26 patients with known or suspected NHL. A primary histological diagnosis was made in 7/7 (six NHL, one seminoma). Relapse was confirmed in 15/15 patients overall. In patients with follicular NHL, 8/15 biopsies showed progression to high grade histology. Biopsies were also performed to assess the nature of residual abnormalities after treatment and to obtain fresh tissue for immunocytochemistry. Tissue was obtained in all cases and a further procedure (two laparotomies, one second needle biopsy) was required on only three occasions. The procedure was well tolerated and there were no complications. This technique is therefore a valuable alternative to more invasive surgical procedures and may be of major benefit in the management of NHL.

Full text

PDF
460

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buscarini L., Cavanna L., Fornari F., Rossi S., Buscarini E. Ultrasonically guided fine-needle biopsy: a new useful technique in pathological staging of malignant lymphoma. Acta Haematol. 1985;73(3):150–152. doi: 10.1159/000206307. [DOI] [PubMed] [Google Scholar]
  2. Cossman J., Jaffe E. S., Fisher R. I. Immunologic phenotypes of diffuse, aggressive, non-Hodgkin's lymphomas. Correlation with clinical features. Cancer. 1984 Oct 1;54(7):1310–1317. doi: 10.1002/1097-0142(19841001)54:7<1310::aid-cncr2820540714>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  3. Cullen M. H., Lister T. A., Brearley R. I., Shand W. S., Stansfeld A. G. Histological transformation of non-Hodgkin's lymphoma: a prospective study. Cancer. 1979 Aug;44(2):645–651. doi: 10.1002/1097-0142(197908)44:2<645::aid-cncr2820440234>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  4. Erwin B. C., Brynes R. K., Chan W. C., Keller J. W., Phillips V. M., Gedgaudas-McClees R. K., Torres W. E., Bernardino M. E. Percutaneous needle biopsy in the diagnosis and classification of lymphoma. Cancer. 1986 Mar 1;57(5):1074–1078. doi: 10.1002/1097-0142(19860301)57:5<1074::aid-cncr2820570535>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  5. Ferrucci J. T., Jr, Wittenberg J., Mueller P. R., Simeone J. F., Harbin W. P., Kirkpatrick R. H., Taft P. D. Diagnosis of abdominal malignancy by radiologic fine-needle aspiration biopsy. AJR Am J Roentgenol. 1980 Feb;134(2):323–330. doi: 10.2214/ajr.134.2.323. [DOI] [PubMed] [Google Scholar]
  6. Gallagher C. J., Gregory W. M., Jones A. E., Stansfeld A. G., Richards M. A., Dhaliwal H. S., Malpas J. S., Lister T. A. Follicular lymphoma: prognostic factors for response and survival. J Clin Oncol. 1986 Oct;4(10):1470–1480. doi: 10.1200/JCO.1986.4.10.1470. [DOI] [PubMed] [Google Scholar]
  7. Goralnik C. H., O'Connell D. M., el Yousef S. J., Haaga J. R. CT-guided cutting-needle biopsies of selected chest lesions. AJR Am J Roentgenol. 1988 Nov;151(5):903–907. doi: 10.2214/ajr.151.5.903. [DOI] [PubMed] [Google Scholar]
  8. Haaga J. R., LiPuma J. P., Bryan P. J., Balsara V. J., Cohen A. M. Clinical comparison of small-and large-caliber cutting needles for biopsy. Radiology. 1983 Mar;146(3):665–667. doi: 10.1148/radiology.146.3.6828680. [DOI] [PubMed] [Google Scholar]
  9. Haaga J. R. New techniques for CT-guided biopsies. AJR Am J Roentgenol. 1979 Oct;133(4):633–641. doi: 10.2214/ajr.133.4.633. [DOI] [PubMed] [Google Scholar]
  10. Hubbard S. M., Chabner B. A., DeVita V. T., Jr, Simon R., Berard C. W., Jones R. B., Garvin A. J., Canellos G. P., Osborne C. K., Young R. C. Histologic progression in non-Hodgkin's lymphoma. Blood. 1982 Feb;59(2):258–264. [PubMed] [Google Scholar]
  11. Husband J. E., Golding S. J. The role of computed tomography-guided needle biopsy in an oncology service. Clin Radiol. 1983 May;34(3):255–260. doi: 10.1016/s0009-9260(83)80323-7. [DOI] [PubMed] [Google Scholar]
  12. Jennings P. E., Donald J. J., Coral A., Rode J., Lees W. R. Ultrasound-guided core biopsy. Lancet. 1989 Jun 17;1(8651):1369–1371. doi: 10.1016/s0140-6736(89)92813-4. [DOI] [PubMed] [Google Scholar]
  13. Knelson M., Haaga J., Lazarus H., Ghosh C., Abdul-Karim F., Sorenson K. Computed tomography-guided retroperitoneal biopsies. J Clin Oncol. 1989 Aug;7(8):1169–1173. doi: 10.1200/JCO.1989.7.8.1169. [DOI] [PubMed] [Google Scholar]
  14. Pontifex A. H., Klimo P. Application of aspiration biopsy cytology to lymphomas. Cancer. 1984 Feb 1;53(3):553–556. doi: 10.1002/1097-0142(19840201)53:3<553::aid-cncr2820530330>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  15. Staab E. V., Jaques P. F., Partain C. L. Percutaneous biopsy in the management of solid intra-abdominal masses of unknown etiology. Radiol Clin North Am. 1979 Dec;17(3):435–459. [PubMed] [Google Scholar]
  16. Tani E. M., Christensson B., Porwit A., Skoog L. Immunocytochemical analysis and cytomorphologic diagnosis on fine needle aspirates of lymphoproliferative disease. Acta Cytol. 1988 Mar-Apr;32(2):209–215. [PubMed] [Google Scholar]
  17. Webb T. H., Lillemoe K. D., Pitt H. A., Jones R. J., Cameron J. L. Pancreatic lymphoma. Is surgery mandatory for diagnosis or treatment? Ann Surg. 1989 Jan;209(1):25–30. doi: 10.1097/00000658-198901000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wotherspoon A. C., Norton A. J., Lees W. R., Shaw P., Isaacson P. G. Diagnostic fine needle core biopsy of deep lymph nodes for the diagnosis of lymphoma in patients unfit for surgery. J Pathol. 1989 Jun;158(2):115–121. doi: 10.1002/path.1711580206. [DOI] [PubMed] [Google Scholar]
  19. Zornoza J., Cabanillas F. F., Altoff T. M., Ordonez N., Cohen M. A. Percutaneous needle biopsy in abdominal lymphoma. AJR Am J Roentgenol. 1981 Jan;136(1):97–103. doi: 10.2214/ajr.136.1.97. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES