Skip to main content
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1991 Jan;31(1):55–63. doi: 10.1111/j.1365-2125.1991.tb03857.x

Backtracking booze with Bayes--the retrospective interpretation of blood alcohol data.

P R Jackson 1, G T Tucker 1, H F Woods 1
PMCID: PMC1368412  PMID: 2015171

Abstract

1. A Bayesian method is described which allows the explicit estimation of errors produced in estimating drug concentrations at times for which samples are not available for analysis. 2. This method was applied to the problem of 'backtracking' alcohol concentrations for medico-legal purposes. 3. Computer simulation allowed the effect of continuing alcohol absorption on the position and range of estimates of alcohol concentrations to be studied.

Full text

PDF
55

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennion L. J., Li T. K. Alcohol metabolism in American Indians and whites. Lack of racial differences in metabolic rate and liver alcohol dehydrogenase. N Engl J Med. 1976 Jan 1;294(1):9–13. doi: 10.1056/NEJM197601012940103. [DOI] [PubMed] [Google Scholar]
  2. Christmore D. S., Kelly R. C., Doshier L. A. Improved recovery and stability of ethanol in automated headspace analysis. J Forensic Sci. 1984 Oct;29(4):1038–1044. [PubMed] [Google Scholar]
  3. Forrest A. R. Non-linear kinetics of ethyl alcohol metabolism. J Forensic Sci Soc. 1986 Mar-Apr;26(2):121–123. doi: 10.1016/s0015-7368(86)72455-9. [DOI] [PubMed] [Google Scholar]
  4. Holford N. H. Clinical pharmacokinetics of ethanol. Clin Pharmacokinet. 1987 Nov;13(5):273–292. doi: 10.2165/00003088-198713050-00001. [DOI] [PubMed] [Google Scholar]
  5. Holtzman J. L., Gebhard R. L., Eckfeldt J. H., Mottonen L. R., Finley D. K., Eshelman F. N. The effects of several weeks of ethanol consumption on ethanol kinetics in normal men and women. Clin Pharmacol Ther. 1985 Aug;38(2):157–163. doi: 10.1038/clpt.1985.152. [DOI] [PubMed] [Google Scholar]
  6. Jones M. K., Jones B. M. Ethanol metabolism in women taking oral contraceptives. Alcohol Clin Exp Res. 1984 Jan-Feb;8(1):24–28. doi: 10.1111/j.1530-0277.1984.tb05026.x. [DOI] [PubMed] [Google Scholar]
  7. Lewis K. O. Back calculation of blood alcohol concentration. Br Med J (Clin Res Ed) 1987 Oct 3;295(6602):800–801. doi: 10.1136/bmj.295.6602.800. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lewis M. J. Blood alcohol: the concentration-time curve and retrospective estimation of level. J Forensic Sci Soc. 1986 Mar-Apr;26(2):95–113. doi: 10.1016/s0015-7368(86)72453-5. [DOI] [PubMed] [Google Scholar]
  9. Nimmo W. S. Drugs, diseases and altered gastric emptying. Clin Pharmacokinet. 1976;1(3):189–203. doi: 10.2165/00003088-197601030-00002. [DOI] [PubMed] [Google Scholar]
  10. Rangno R. E., Kreeft J. H., Sitar D. S. Ethanol 'dose-dependent' elimination: Michaelis-Menten v classical kinetic analysis. Br J Clin Pharmacol. 1981 Nov;12(5):667–673. doi: 10.1111/j.1365-2125.1981.tb01287.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sedman A. J., Wilkinson P. K., Sakmar E., Weidler D. J., Wagner J. G. Food effects on absorption and metabolism of alcohol. J Stud Alcohol. 1976 Sep;37(9):1197–1214. doi: 10.15288/jsa.1976.37.1197. [DOI] [PubMed] [Google Scholar]
  12. Sheiner L. B., Beal S., Rosenberg B., Marathe V. V. Forecasting individual pharmacokinetics. Clin Pharmacol Ther. 1979 Sep;26(3):294–305. doi: 10.1002/cpt1979263294. [DOI] [PubMed] [Google Scholar]
  13. Taberner P. V. Pharmacokinetics of alcohol and the law. Trends Pharmacol Sci. 1988 Feb;9(2):47–48. doi: 10.1016/0165-6147(88)90113-7. [DOI] [PubMed] [Google Scholar]
  14. Vestal R. E., McGuire E. A., Tobin J. D., Andres R., Norris A. H., Mezey E. Aging and ethanol metabolism. Clin Pharmacol Ther. 1977 Mar;21(3):343–354. doi: 10.1002/cpt1977213343. [DOI] [PubMed] [Google Scholar]
  15. Whiting B., Kelman A. W., Grevel J. Population pharmacokinetics. Theory and clinical application. Clin Pharmacokinet. 1986 Sep-Oct;11(5):387–401. doi: 10.2165/00003088-198611050-00004. [DOI] [PubMed] [Google Scholar]
  16. Wilkinson P. K., Sedman A. J., Sakmar E., Kay D. R., Wagner J. G. Pharmacokinetics of ethanol after oral administration in the fasting state. J Pharmacokinet Biopharm. 1977 Jun;5(3):207–224. doi: 10.1007/BF01065396. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES