Skip to main content
NCBI home page
Biochemical Journal logoLink to Biochemical Journal
. 1977 Nov 15;168(2):271–275. doi: 10.1042/bj1680271

Enhancement of the anti-anabolic response to adenosine 3':5'-cyclic monophosphate during development. The inhibition of hepatic protein synthesis.

A Klaipongpan, D P Bloxham, M Akhtar
PMCID: PMC1183760  PMID: 202263

Abstract

Cyclic AMP causes an age-dependent inhibition of protein synthesis in rat liver. The onset of inhibition is about 10--12 days after birth. The developmental response to cyclic AMP is associated with a change in the microsomal component of the protein-synthesizing system.

Full text

PDF
271

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ballard F. J., Hanson R. W. Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver. Biochem J. 1967 Sep;104(3):866–871. doi: 10.1042/bj1040866. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ballard F. J. Regulation of gluconeogenesis during exposure of young rats to hypoxic conditions. Biochem J. 1971 Jan;121(2):169–178. doi: 10.1042/bj1210169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bricker L. A., Levey G. S. Autonomous cholesterol and fatty acid synthesis in hepatomas: deletion of the adenosine 3',5'-cyclic monophosphate control mechanism of normal liver. Biochem Biophys Res Commun. 1972 Jul 25;48(2):362–365. doi: 10.1016/s0006-291x(72)80059-7. [DOI] [PubMed] [Google Scholar]
  4. Bricker L. A., Levey G. S. Evidence for regulatin of cholesterol and fatty acid synthesis in liver by cyclic adenosine 3',5'-monophosphate. J Biol Chem. 1972 Aug 10;247(15):4914–4915. [PubMed] [Google Scholar]
  5. CLELAND K. W., SLATER E. C. Respiratory granules of heart muscle. Biochem J. 1953 Mar;53(4):547–556. doi: 10.1042/bj0530547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Capuzzi D. M., Rothman V., Margolis S. The regulation of lipogenesis by cyclic nucleotides in intact hepatocytes prepared by a simplified technique. J Biol Chem. 1974 Feb 25;249(4):1286–1294. [PubMed] [Google Scholar]
  7. Clark M. G., Bloxham D. P., Holland P. C., Lardy H. A. Estimation of the fructose 1,6-diphosphatase-phosphofructokinase substrate cycle and its relationship to gluconeogenesis in rat liver in vivo. J Biol Chem. 1974 Jan 10;249(1):279–290. [PubMed] [Google Scholar]
  8. Exton J. H., Corbin J. G., Harper S. C. Control of gluconeogenesis in liver. V. Effects of fasting, diabetes, and glucagon on lactate and endogenous metabolism in the perfused rat liver. J Biol Chem. 1972 Aug 25;247(16):4996–5003. [PubMed] [Google Scholar]
  9. Exton J. H., Mallette L. E., Jefferson L. S., Wong E. H., Friedmann N., Miller T. B., Jr, Park C. R. The hormonal control of hepatic gluconeogenesis. Recent Prog Horm Res. 1970;26:411–461. doi: 10.1016/b978-0-12-571126-5.50014-5. [DOI] [PubMed] [Google Scholar]
  10. Exton J. H., Park C. R. Control of gluconeogenesis in liver. 3. Effects of L-lactate, pyruvate, fructose, glucagon, epinephrine, and adenosine 3',5'-monophosphate on gluconeogenic intermediates in the perfused rat liver. J Biol Chem. 1969 Mar 25;244(6):1424–1433. [PubMed] [Google Scholar]
  11. Exton J. H., Park C. R. Control of gluconeogenesis in liver. II. Effects of glucagon, catecholamines, and adenosine 3',5'-monophosphate on gluconeogenesis in the perfused rat liver. J Biol Chem. 1968 Aug 25;243(16):4189–4196. [PubMed] [Google Scholar]
  12. Ferre P., Pegorier J. P., Girard J. The effects of inhibition of gluconeogenesis in suckling newborn rats. Biochem J. 1977 Jan 15;162(1):209–212. doi: 10.1042/bj1620209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Foster P. C., Bailey E. Changes in the activities of the enzymes of hepatic fatty acid oxidation during development of the rat. Biochem J. 1976 Jan 15;154(1):49–56. doi: 10.1042/bj1540049. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Harris R. A. Studies on the inhibition of hepatic lipogenesis by N-6,O-2'-dibutyryl adenosine 3',5'-monophosphate. Arch Biochem Biophys. 1975 Jul;169(1):168–180. doi: 10.1016/0003-9861(75)90330-6. [DOI] [PubMed] [Google Scholar]
  15. Hoshino J., Kuhne U., Studinger G., Kröger H. In vitro protein synthesizing activity of rat liver as influenced by a physiological dose of cortisone and dibutyryl cyclic AMP. Biochem Biophys Res Commun. 1977 Jan 24;74(2):663–669. doi: 10.1016/0006-291x(77)90354-0. [DOI] [PubMed] [Google Scholar]
  16. Klain G. J., Weiser P. C. Changes in hepatic fatty acid synthesis following glucagon injections in vivo. Biochem Biophys Res Commun. 1973 Nov 1;55(1):76–83. doi: 10.1016/s0006-291x(73)80061-0. [DOI] [PubMed] [Google Scholar]
  17. Klaipongpan A., Bloxham D. P., Akhtar M. The requirement for a membrane component to demonstrate the inhibition of cell-free protein synthesis by cyclic AMP. FEBS Lett. 1975 Oct 15;58(1):81–84. doi: 10.1016/0014-5793(75)80230-4. [DOI] [PubMed] [Google Scholar]
  18. Klaipongpan A., Bloxham D. P., Akhtar M. The role of adenosine 3':5'-cyclic monophosphate in the growth and development of rat liver. Biochem Soc Trans. 1976;4(6):1068–1069. doi: 10.1042/bst0041068. [DOI] [PubMed] [Google Scholar]
  19. Mallet L. E., Exton J. H., Park C. R. Control of gluconeogenesis from amino acids in the perfused rat liver. J Biol Chem. 1969 Oct 25;244(20):5713–5723. [PubMed] [Google Scholar]
  20. Monier D., Santhanam K., Wagle S. R. Studies on the inhibition of amino acid incorporation into protein by isolated rat liver ribosomes by protein kinase. Biochem Biophys Res Commun. 1972 Mar 10;46(5):1881–1886. doi: 10.1016/0006-291x(72)90065-4. [DOI] [PubMed] [Google Scholar]
  21. Salmon D. M., Bowen N. L., Hems D. A. Synthesis of fatty acids in the perused mouse liver. Biochem J. 1974 Sep;142(3):611–618. doi: 10.1042/bj1420611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Sellers A., Bloxham D. P., Munday K. A., Akhtar M. Anti-anabolic effects of adenosine 3':5'-cyclic monophosphate. Inhibition of protein synthesis. Biochem J. 1974 Mar;138(3):335–340. doi: 10.1042/bj1380335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Taylor C. B., Bailey E., Bartley W. Changes in hepatic lipigenesis during development of the rat. Biochem J. 1967 Nov;105(2):717–722. doi: 10.1042/bj1050717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Woodside K. H. Effects of cycloheximide on protein degradation and gluconeogenesis in the perfused rat liver. Biochim Biophys Acta. 1976 Jan 14;421(1):70–79. doi: 10.1016/0304-4165(76)90170-7. [DOI] [PubMed] [Google Scholar]
  25. Zahlten R. N., Stratman F. W. The isolation of hormone-sensitive rat hepatocytes by a modified enzymatic technique. Arch Biochem Biophys. 1974 Aug;163(2):600–608. doi: 10.1016/0003-9861(74)90519-0. [DOI] [PubMed] [Google Scholar]
  26. van de Werve G., Hue L., Hers H. G. Hormonal and ionic control of the glycogenolytic cascade in rat liver. Biochem J. 1977 Jan 15;162(1):135–142. doi: 10.1042/bj1620135. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES