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. 1978 Jun;80(3):451–459. doi: 10.1017/s002217240002492x

In vitro comparison of foot-and-mouth disease virus subtype variants causing disease in vaccinated cattle.

E C Anderson, W J Doughty, J Anderson, D Baber
PMCID: PMC2129798  PMID: 206626

Abstract

Foot-and-mouth disease virus isolates of types O, A and SAT 2, from diseased animals in herds routinely vaccinated twice a year were compared antigenically with the vaccine strains in the complement-fixation, neutralization and radial immunodiffusion tests. It was found that strains which had readily infected vaccinated cattle had R values against the vaccine strain in the complementfixation and radial immunodiffusion tests of 30 or less, while strains causing primary outbreaks with little spread had R values of 30-40. Threefold differences in humoral neutralizing antibody concentration between the field variant and the vaccine strain in sera from vaccinated animals were likely to be significant in terms of protection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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