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Journal of Feline Medicine and Surgery logoLink to Journal of Feline Medicine and Surgery
. 2010 Oct 1;12(10):754–759. doi: 10.1016/j.jfms.2010.05.012

Cysteinyl-leukotriene receptor antagonism blunts the acute hypotensive response to endotoxin in cats

Amy E DeClue 1, Claire R Sharp 2, Rachael L Cohen 3, Elizabeth F Leverenz 4, Carol R Reinero 5
PMCID: PMC11135526  PMID: 20719552

Abstract

This study evaluated the effects of a cysteinyl-leukotriene-1 (cys-LT-1) receptor antagonist, zarfirlukast, during feline endotoxemia. Six adult, sexually intact male cats received either placebo or zarfirlukast (10 mg, PO) and endotoxin (2 μg/kg/h q 6 h) in a cross-over design. Rectal temperature, heart rate, systolic arterial blood pressure, plasma tumor necrosis factor (TNF) activity, interleukin (IL)-6 concentration and urine cys-LT to creatinine ratio were evaluated. The rectal temperature, plasma TNF activity and IL-6 concentrations were significantly higher and systolic arterial blood pressure and heart rate significantly lower after endotoxin infusion. Cats treated with zafirlukast had a significantly higher blood pressure at 4 h (P=0.002) compared to placebo. Urine cys-LT to creatinine ratio was significantly greater in the cats treated with zafirlukast compared to placebo (P=0.02). Zafirlukast administration ameliorated the acute hypotensive response to endotoxin in cats, but failed to significantly alter rectal temperature, heart rate or production of TNF and IL-6.

Contributor Information

Amy E. DeClue, Department of Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 E Campus Drive, Columbia, MO 65211, USA  decluea@missouri.edu

Claire R. Sharp, Department of Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 E Campus Drive, Columbia, MO 65211, USA

Rachael L. Cohen, Department of Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 E Campus Drive, Columbia, MO 65211, USA

Elizabeth F. Leverenz, Department of Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 E Campus Drive, Columbia, MO 65211, USA

Carol R. Reinero, Department of Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 E Campus Drive, Columbia, MO 65211, USA

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