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. 1985 Aug;31:1527–1529.

Diagnosing Infectious Mononucleosis: Avoiding the Pitfalls

J A McSherry
PMCID: PMC2327388  PMID: 21274039

Abstract

Infectious mononucleosis may be diagnosed with confidence only when Hoagland's diagnostic criteria have been met. The illness must be compatible with the known clinical features of infectious mononucleosis; there should be absolute and relative lymphocytosis on differential white cell count; there should be more than 20% atypical lymphocytes and serological tests should be positive—either a Paul-Bunnell Davidsohn or a rapid slide test for heterophil antibody. Failure to diagnose this common viral infection accurately may lead to inappropriate and perhaps harmful management, and may delay recognition of potentially life-threatening complications.

Keywords: mononucleosis, diagnosis, infection

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. English E. C., Geyman J. P. The efficiency and cost effectiveness of diagnostic tests for infectious mononucleosis. J Fam Pract. 1978 May;6(5):977–981. [PubMed] [Google Scholar]
  2. Evans A. S., Niederman J. C., Cenabre L. C., West B., Richards V. A. A prospective evaluation of heterophile and Epstein-Barr virus-specific IgM antibody tests in clinical and subclinical infectious mononucleosis: Specificity and sensitivity of the tests and persistence of antibody. J Infect Dis. 1975 Nov;132(5):546–554. doi: 10.1093/infdis/132.5.546. [DOI] [PubMed] [Google Scholar]
  3. Fermaglich D. R. Pulmonary involvement in infectious mononucleosis. J Pediatr. 1975 Jan;86(1):93–95. doi: 10.1016/s0022-3476(75)80712-8. [DOI] [PubMed] [Google Scholar]
  4. Fisher M., Shenker I. R., Nussbaum M. P. Infectious mononucleosis; review of complications in hospitalized series. N Y State J Med. 1980 May;80(6):929–934. [PubMed] [Google Scholar]
  5. Grose C., Henle W., Henle G., Feorino P. M. Primary Epstein-Barr-virus infections in acute neurologic diseases. N Engl J Med. 1975 Feb 20;292(8):392–395. doi: 10.1056/NEJM197502202920804. [DOI] [PubMed] [Google Scholar]
  6. McSherry J. Acute pharyngitis: a symptom scorecard and microbiological diagnosis. Br Med J (Clin Res Ed) 1982 Mar 13;284(6318):824–825. doi: 10.1136/bmj.284.6318.824-c. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Murray B. J. Medical complications of infectious mononucleosis. Am Fam Physician. 1984 Nov;30(5):195–199. [PubMed] [Google Scholar]
  8. Penman H. G. Fatal infectious mononucleosis: a critical review. J Clin Pathol. 1970 Dec;23(9):765–771. doi: 10.1136/jcp.23.9.765. [DOI] [PMC free article] [PubMed] [Google Scholar]

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