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. 1990 Feb;74(2):89–92. doi: 10.1136/bjo.74.2.89

An outbreak of acute haemorrhagic conjunctivitis in Kaduna, Nigeria.

O E Babalola 1, S S Amoni 1, E Samaila 1, U Thaker 1, S Darougar 1
PMCID: PMC1041997  PMID: 2155654

Abstract

Clinical studies were carried out on two groups of patients with acute haemorrhagic conjunctivitis (AHC) during an epidemic in 1985 in Northern Nigeria. Group 1 consisted of 99 students attending a girls' boarding school, group 2 of 200 patients selected randomly from 1000 examined at the local clinic. Moderate to severe hyperaemia and papillary responses were present in the palpebral conjunctiva of all patients, and 234 (66%) had subconjunctival haemorrhages. Transient superficial punctate keratitis was noted in over 60% of patients. A transient flare suggestive of a low grade iritis was seen in five patients. No neurological disorders were noted. Serological studies were carried out on patients from group 2. Fifteen paired and 20 single serum samples were titrated against adenovirus type 4 (Ad-4) and enterovirus type 70 (EV-70). Two pairs of sera showed a 4-fold rise in antibody levels to EV-70, whereas the antibody titres to EV-70 in the rest of the sera ranged from 1:20 (no antibody) to 1:160. None of the paired serum samples showed a 4-fold rise in antibody levels to adenovirus. The results of clinical studies and serological findings support EV-70 as a probable cause of AHC in Nigeria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chatterjee S., Quarcoopome C. O., Apenteng A. Unusual type of epidemic conjunctivitis in Ghana. Br J Ophthalmol. 1970 Sep;54(9):628–630. doi: 10.1136/bjo.54.9.628. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Desmyter J., Colaert J., Maertens K., Muyembe T. Enterovirus 70 haemorrhagic conjunctivitis in Zäire, 1981 versus 1972. Lancet. 1981 Nov 7;2(8254):1054–1055. doi: 10.1016/s0140-6736(81)91257-5. [DOI] [PubMed] [Google Scholar]
  3. John T. J., Christopher S., Abraham J. Neurological manifestation of acute haemorrhagic conjunctivitis due to enterovirus 70. Lancet. 1981 Dec 5;2(8258):1283–1284. doi: 10.1016/s0140-6736(81)91516-6. [DOI] [PubMed] [Google Scholar]
  4. Kono R., Miyamura K., Ogino T., Wadia N. H., Wadia P. N., Katrak S. M., Misra V. P. Antibody titres to enterovirus type 70 in the 1981 Indian epidemic of acute haemorrhagic conjunctivitis. Lancet. 1981 Oct 24;2(8252):924–925. [PubMed] [Google Scholar]
  5. Kono R., Miyamura K., Tajiri E., Shiga S., Sasagawa A., Irani P. F., Katrak S. M., Wadia N. H. Neurologic complications associated with acute hemorrhagic conjunctivitis virus infection and its serologic confirmation. J Infect Dis. 1974 May;129(5):590–593. doi: 10.1093/infdis/129.5.590. [DOI] [PubMed] [Google Scholar]
  6. Kono R., Sasagawa A., Miyamura K., Tajiri E. Serologic characterization and sero-epidemiologic studies on acute hemorrhagic conjunctivitis (AHC) virus. Am J Epidemiol. 1975 May;101(5):444–457. doi: 10.1093/oxfordjournals.aje.a112112. [DOI] [PubMed] [Google Scholar]
  7. McMoli T. E., Bordoh A. N., Munube G. M., Bell E. J. Epidemic acute haemorrhagic conjunctivitis in Lagos, Nigeria. Br J Ophthalmol. 1984 Jun;68(6):401–404. doi: 10.1136/bjo.68.6.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Mirkovic R. R., Schmidt N. J., Yin-Murphy M., Melnick J. L. Enterovirus etiology of the 1970 Singapore epidemic of acute conjunctivitis. Intervirology. 1974;4(2):119–127. doi: 10.1159/000149850. [DOI] [PubMed] [Google Scholar]
  9. Yin-Murphy M., Lim K. H., Chua P. H. Adenovirus type 11 epidemic conjunctivitis in Singapore. Southeast Asian J Trop Med Public Health. 1974 Sep;5(3):333–341. [PubMed] [Google Scholar]

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