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. 1979 Jan-Feb;52(1):107–116.

Effect of Prostaglandins on Hepatic Cyclic Nucleotide Concentration, Carbohydrate and Lipid Metabolism

Robert A Levine
PMCID: PMC2595716  PMID: 222076

Abstract

The effects of exogenous prostaglandin E1 (PGE1) or prostaglandin E2 (PGE2) were studied in the isolated perfused rat liver and in the intact canine liver in order to determine the possible physiological role of prostaglandins on hepatic carbohydrate and lipid metabolism. The data indicate that PGE1 and PGE2 did not stimulate cyclic AMP (cAMP) and cyclic GMP (cGMP) concentrations in intact dog liver and PGE1 failed to stimulate cAMP or cGMP in fed or fasted perfused rat liver. PGE1 did not promote hyperglycemia, glycogenolysis, lipolysis, or prevent epinephrine-induced hyperglycemia in the isolated perfused rat liver. Other known glycogenolytic agents including glucagon and epinephrine increased cAMP and glycogenolysis in the same perfusion system. This study does not support a physiologic role for PGE1 on hepatic glycogenolysis or lipolysis. If PGE1 subsequently is found to influence other metabolic parameters such as lipogenesis, gluconeogenesis, ureogenesis or amino acid transport in isolated perfused liver, such alterations would probably occur independent of changes in cyclic nucleotide activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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