Skip to main content
NCBI home page
The Indian Journal of Surgery logoLink to The Indian Journal of Surgery
. 2009 May 2;71(2):73–77. doi: 10.1007/s12262-009-0020-9

The effect of Kombucha on post-operative intra-abdominal adhesion formation in rats

Hemmat Maghsoudi 1,✉, Hussein Benagozar Mohammadi 1
PMCID: PMC3452607  PMID: 23133119

Abstract

Background

Peritoneal adhesions are fibrous bands of tissues formed between organs that are normally separated and/or between organs and the internal body wall after peritoneal injury. The aim of the study was to investigate the effect of intra-peritoneal administration of Kombucha on intra-peritoneal adhesions.

Materials and methods

Eighty Wistar rats were subjected to standardized lesion by scraping model and were randomly divided into two groups. Group I received no treatment, and Group II received 15 ml of Kombucha solution intra-peritoneally. On the post-operative 14th day adhesion intensity score, inflammatory cell reaction and number of adhesion bands were determined.

Results

In the control group, there were no rats with grade 0 and I adhesions. In the group II, there were 26 rats (78.8%) with grade 0–2 adhesions. Adhesion intensity was significantly less in group II (P<0.0001). Number of adhesion bands was significantly less in group II (P<0.001).

Conclusion

It was concluded that intra-peritoneal administration of Kombucha might be useful for preventing peritoneal adhesions.

Keywords: Peritoneal adhesions, Kombucha, Prevention

Full Text

The Full Text of this article is available as a PDF (603.3 KB).

References

  • 1.Ellis H., Moran B., Thompson J. Adhesion related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study. Lancet. 1999;353:1476–1480. doi: 10.1016/S0140-6736(98)09337-4. [DOI] [PubMed] [Google Scholar]
  • 2.Cheong Y.C., Laird S.M., Li T.C., Shelton J.B., Ledger W.L., Cooke I.D. Peritoneal healing and adhesion formation/reformation. Hum Reprod. 2001;7(6):556–566. doi: 10.1093/humupd/7.6.556. [DOI] [PubMed] [Google Scholar]
  • 3.DiZerega G.S., Campeau J.D. Peritoneal repair and postsurgical adhesion formation. Hum Reprod Update. 2001;7(6):547–555. doi: 10.1093/humupd/7.6.547. [DOI] [PubMed] [Google Scholar]
  • 4.Milligan D.W., Raftery A.T. Observations on the pathogenesis of peritoneal adhesions: a fight and electron microscopically study. Br J Surg. 1974;61:274–280. doi: 10.1002/bjs.1800610406. [DOI] [PubMed] [Google Scholar]
  • 5.DiZerega GS. The peritoneum and its response to surgical injury. In: diZerega ZG, Malinak L, Diamond M, Linsky C, editors. Treatment of post-surgical adhesions. New York: Wiley Liss. pp 166–171
  • 6.Nair S., Bhat I., Aurora A. Role of proteolytic enzyme in the prevention of post-operative intraperitoneal adhesions. Arch Surg. 1974;108:849–853. doi: 10.1001/archsurg.1974.01350300081019. [DOI] [PubMed] [Google Scholar]
  • 7.Menzies D., Ellis H. Intestinal obstruction from adhesions. How big is the problem? Ann R Coll Surg Engl. 1990;72:60–63. [PMC free article] [PubMed] [Google Scholar]
  • 8.Ellis H. The cause and prevention of post-operative intraperitoneal adhesions. Surg Gynecol Obstet. 1971;133:497–511. [PubMed] [Google Scholar]
  • 9.Hers A., Diamond M.P., DeCherney A.H. Adhesiolysis. Clin Obstet Gynecol. 1991;34:395–398. doi: 10.1097/00003081-199106000-00023. [DOI] [PubMed] [Google Scholar]
  • 10.Afyez J.A. An assessment of the role of operative laparoscopy in tuboplasty. Fertil Steril. 1983;39:476–479. doi: 10.1016/s0015-0282(16)46935-9. [DOI] [PubMed] [Google Scholar]
  • 11.Ellis H. The causes and prevention of intestinal adhesions. Br J Surg. 1982;68:241–243. doi: 10.1002/bjs.1800690502. [DOI] [PubMed] [Google Scholar]
  • 12.Treutner K.H., Schumpelick V. Adhesion prevention. Wish and reality. Chirurg. 2000;71:510–517. doi: 10.1007/s001040050848. [DOI] [PubMed] [Google Scholar]
  • 13.Alponat A., Lakshminarasappa S.R., Yavuz N., Goh P.M. Prevention of adhesions by Seprafilm, an absorbable adhesion barrier: an incisional hernia model in rats. Am Surg. 1997;63:818–819. [PubMed] [Google Scholar]
  • 14.Frank GK (1996) Healthy beverage from the Far East. Its correct preparation and use. Ennsthaler. Steyr
  • 15.Blance P (1995) Research on tea fungus. Draft of research article posted to Kombucha Discussion list
  • 16.Larsson B., Svanberg S.G., Swolin K. Oxyphen-butazone, an adjuvant to be used in prevention of adhesion in operations for fertility. Fertil Steril. 1977;28:807–809. doi: 10.1016/s0015-0282(16)42731-7. [DOI] [PubMed] [Google Scholar]
  • 17.Luciano A.A., Hauser, Benda J. Evaluation of commonly used adjuvants in the prevention of postoperative adhesions. Am J Obstet Gynecol. 1983;146:88–91. doi: 10.1016/0002-9378(83)90932-8. [DOI] [PubMed] [Google Scholar]
  • 18.Elkins T.E., Bury R.J., Ritter J.I. Adhesion prevention by solutions of sodium carboxymethyl cellulose in rat. Fertil Steril. 1984;41:926–928. doi: 10.1016/s0015-0282(16)47909-4. [DOI] [PubMed] [Google Scholar]
  • 19.Evans D.M., Mc Aree K., Guyton D.P. Dose dependency and wound healing aspects of the use of tissue plasminogen activator in the prevention of intra-abdominal adhesions. Am J Surg. 1993;165:229–232. doi: 10.1016/S0002-9610(05)80516-1. [DOI] [PubMed] [Google Scholar]
  • 20.Dijkstra F.R., Nieuwenhuijzen M., Reijnen M.M., et al. Recent clinical developments in pathophysiology, epidemiology, diagnosis and treatment of intr-abdominal adhesions. Scand J Gastroenterol SUPPL. 2000;232:52. [PubMed] [Google Scholar]
  • 21.Cheong Y.C., Laird S.M., Shellton J.B. The correlation of adhesions and peritoneal fluid cytokine concentrations: A pilot study. Hum Reprod. 2002;17:1039. doi: 10.1093/humrep/17.4.1039. [DOI] [PubMed] [Google Scholar]
  • 22.Costain D.J., Kennedy R., Ciona C., Mc Alister V.C. Prevention of postsurgical adhesions with N,O-carboxymethyl chitosan: examination of the most efficacious preparation and the effect of N,O-carboxymethyl chitosan healing. Surgery. 1997;121:314–319. doi: 10.1016/S0039-6060(97)90360-3. [DOI] [PubMed] [Google Scholar]
  • 23.Kennedy R., Costain D.J., Mc Alister V.C. Prevention of experimental post-operative peritoneal adhesions by N,O-carboxymethyl chitosan. Surgery. 1996;120:866–870. doi: 10.1016/S0039-6060(96)80096-1. [DOI] [PubMed] [Google Scholar]
  • 24.Ozogul Y., Baykal A., Onat D., Renda N., Sayek I. An experimental study of the effect of Aprotinin on intestinal adhesion formation. Am J Surg. 1998;175:137–141. doi: 10.1016/S0002-9610(97)00273-0. [DOI] [PubMed] [Google Scholar]
  • 25.Kagoma P., Burger S.N., Seifter E., Levenson S.M., Achilles A. The effect of vitamin E on experimentally induced peritoneal adhesions in mice. Arch Surg. 1985;120:949–951. doi: 10.1001/archsurg.1985.01390320073015. [DOI] [PubMed] [Google Scholar]
  • 26.Snoj M., Ar’Rajab A., Ahren B., Larsson K., Bengmark S. Phospholipase-resistant phosphatidylcholine reduces intra-abdominal adhesions induced by bacterial peritonitis. Res Exp Med. 1993;193:117–122. doi: 10.1007/BF02576218. [DOI] [PubMed] [Google Scholar]
  • 27.Nagler A., Rivkind A.I., Raphael J., Schaffer F.L., Genina O. Halofuginone—an inhibitor of collagen type I synthesis—prevents post-operative formation of abdominal adhesions. Ann Surg. 1998;227:575–582. doi: 10.1097/00000658-199804000-00021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 28.Galili Y., Abraham R.B., Rabau M., Klausner J., Kluger Y. Reduction of surgery induced peritoneal adhesions by methylene blue. Am J Surg. 1998;75:30–32. doi: 10.1016/S0002-9610(97)00232-8. [DOI] [PubMed] [Google Scholar]
  • 29.Roussin M (1996) Out on the Kombucha range. Post to Kombucha Discussion list

Articles from The Indian Journal of Surgery are provided here courtesy of Springer

RESOURCES