We read with great interest the article “Roux en Y Gastric Bypass Increases Ethanol Intake in the Rat” [1] from Jon Davis and colleagues, published on line in the Obesity Surgery on February 26, 2013. This study reports an impressive data set showing increased alcohol consumption in an outbred rat strain after Roux-en Y gastric bypass surgery (RYGB), a finding that has potential important clinical implications. This study supports recent clinical investigations showing increased susceptibility to alcohol abuse following RYGB [2-5] and corroborate our recent studies that reported increased alcohol taking, and increased motivation to work for alcohol reward in dietary obese rats that received RYGB [6, 7].
However we were surprised that the authors did not refer to prior publications showing similar outcomes [6, 7], which would have strengthen the conclusion of their paper. The authors also failed to cite their prior paper [8], which reported decreases in alcohol intake after RYGB in alcohol-preferring rats as well as decreased alcohol intake after RYGB in patients who regularly drank alcohol prior to undergoing surgery. The differences between their current results and their prior findings suggest that the effects of RYGB may be modulated by genetic background and should have been discussed rather than ignored.
There are increasing concerns over the lack of reproducibility of findings from preclinical research [9], yet study of Davis et al. show similar findings to the ones we previously reported using a similar animal model and surgical procedure but done by an independent laboratory.
Footnotes
The authors have no conflict of interest to report.
References
- 1.Davis JF, et al. Roux en Y Gastric Bypass Increases Ethanol Intake in the Rat. Obes Surg. 2013 doi: 10.1007/s11695-013-0884-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Ertelt TW, et al. Alcohol abuse and dependence before and after bariatric surgery: a review of the literature and report of a new data set. Surg Obes Relat Dis. 2008;4(5):647–50. doi: 10.1016/j.soard.2008.01.004. [DOI] [PubMed] [Google Scholar]
- 3.Hsu LK, et al. Nonsurgical factors that influence the outcome of bariatric surgery: a review. Psychosom Med. 1998;60(3):338–46. doi: 10.1097/00006842-199805000-00021. [DOI] [PubMed] [Google Scholar]
- 4.Saules KK, et al. Bariatric surgery history among substance abuse treatment patients: prevalence and associated features. Surg Obes Relat Dis. 2010;6(6):615–21. doi: 10.1016/j.soard.2009.12.008. [DOI] [PubMed] [Google Scholar]
- 5.King WC, et al. Prevalence of alcohol use disorders before and after bariatric surgery. JAMA. 2012;307(23):2516–25. doi: 10.1001/jama.2012.6147. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.Hajnal A, et al. Alcohol reward is increased after Roux-en-Y gastric bypass in dietary obese rats with differential effects following ghrelin antagonism. PLoS One. 2012;7(11):e49121. doi: 10.1371/journal.pone.0049121. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Thanos PK, et al. Gastric bypass increases ethanol and water consumption in diet-induced obese rats. Obes Surg. 2012;22(12):1884–92. doi: 10.1007/s11695-012-0749-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Davis JF, et al. Gastric bypass surgery attenuates ethanol consumption in ethanol-preferring rats. Biol Psychiatry. 2012;72(5):354–60. doi: 10.1016/j.biopsych.2012.01.035. [DOI] [PubMed] [Google Scholar]
- 9.Prinz F, Schlange T, Asadullah K. Believe it or not: how much can we rely on published data on potential drug targets? Nat Rev Drug Discov. 2011;10(9):712. doi: 10.1038/nrd3439-c1. [DOI] [PubMed] [Google Scholar]