Abstract
Transplanted syngeneic osteosarcomas (induced by 32P in DA rats) grew significantly larger in DA rats receiving a simultaneous transplant of allogeneic osteosarcoma than in rats receiving syngeneic tumour only (P less than 0-01). Two other malignant allogeneic tumours, and allogeneic spleen cells, did not alter the growth of the transplanted syngeneic osteosarcomas. When the allogeneic osteosarcoma was given 7 days before the syngeneic tumour, the reverse effect (retardation) occurred. When given 7 days after the syngeneic tumour cells, the effect on both syngeneic and allogeneic tumour growth was variable. Some possible reasons for these findings are discussed, and the argument is presented that immunological phenonema are involved in the reaction.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baldwin R. W., Price M. R., Robins R. A. Blocking of lymphocyte-mediated cytotoxicity for rat hepatoma cells by tumour-specific antigen-antibody complexes. Nat New Biol. 1972 Aug 9;238(84):185–186. doi: 10.1038/newbio238185a0. [DOI] [PubMed] [Google Scholar]
- Britton S. Growth-retarding mechanisms against lymphatic tumours. Search in mice and men. Transplant Rev. 1971;7:146–178. doi: 10.1111/j.1600-065x.1971.tb00466.x. [DOI] [PubMed] [Google Scholar]
- Crowther D., Powles R. L., Bateman C. J., Beard M. E., Gauci C. L., Wrigley P. F., Malpas J. S., Fairley G. H., Scott R. B. Management of adult acute myelogenous leukaemia. Br Med J. 1973 Jan 20;1(5846):131–137. doi: 10.1136/bmj.1.5846.131. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Geddes-Dwyer V., Bosanquet J. S., O'Grady R. L., Cameron D. A. Transplantation and tissue culture studies of radiation-induced osteosarcoma in the rat. Pathology. 1974 Jan;6(1):71–78. doi: 10.3109/00313027409077158. [DOI] [PubMed] [Google Scholar]
- KLEIN G., SJOGREN H. O., KLEIN E. Demonstration of host resistance against isotransplantation of lymphomas induced by the Gross agent. Cancer Res. 1962 Sep;22:955–961. [PubMed] [Google Scholar]
- Kobayashi H., Gotoda E., Kuzumaki N., Takeichi N., Hosokawa M. Reduced transplantability of syngeneic tumors in rats immunized with allogeneic tumors. Int J Cancer. 1974 Apr 15;13(4):522–529. doi: 10.1002/ijc.2910130412. [DOI] [PubMed] [Google Scholar]
- Mathé G., Pouillart P., Schwarzenberg L., Amiel J. L., Schneider M., Hayat M., De Vassal F., Jasmin C., Rosenfeld C., Weiner R. Attempts at immunotherapy of 100 patients with acute lymphoid leukemia: some factors influencing results. Natl Cancer Inst Monogr. 1972 Dec;35:361–372. [PubMed] [Google Scholar]
- McBride R. A., Schierman L. W. Thymus dependency of antibody-mediated helper effect. J Immunol. 1973 Jun;110(6):1710–1712. [PubMed] [Google Scholar]
- Romsdahl M. M., Cox I. S. Immunological studies on malignant melanomas of man. Yale J Biol Med. 1973 Dec;46(5):693–701. [PMC free article] [PubMed] [Google Scholar]
- Schierman L. W., McBride R. A. Adjuvant activity of erythrocyte isoantigens. Science. 1967 May 5;156(3775):658–659. doi: 10.1126/science.156.3775.658. [DOI] [PubMed] [Google Scholar]