Skip to main content
NCBI home page
Annals of Surgery logoLink to Annals of Surgery
. 1988 Jan;207(1):4–6. doi: 10.1097/00000658-198801000-00002

Incidence of perforated and bleeding peptic ulcers before and after the introduction of H2-receptor antagonists.

A Christensen 1, R Bousfield 1, J Christiansen 1
PMCID: PMC1493241  PMID: 2892468

Abstract

The incidence of perforated and bleeding peptic ulcer requiring emergency surgery was studied in a defined population before and after the introduction of histamine H2-blockers. The incidence of these ulcer complications was unchanged from 1974 to 1984 with an incidence of ulcer perforation from 4 to 10/100,000 per year and of bleeding ulcer from 5 to 10/100,000, indicating that the H2-blockers have not changed the incidence of severe ulcer complications.

Full text

PDF
4

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bulthuis R., Laing W. A. Cost effectiveness of cimetidine. Lancet. 1982 Oct 9;2(8302):828–829. doi: 10.1016/s0140-6736(82)92725-8. [DOI] [PubMed] [Google Scholar]
  2. Collier D. S., Pain J. A. Non-steroidal anti-inflammatory drugs and peptic ulcer perforation. Gut. 1985 Apr;26(4):359–363. doi: 10.1136/gut.26.4.359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Fineberg H. V., Pearlman L. A. Surgical treatment of peptic ulcer in the United States. Trends before and after the introduction of cimetidine. Lancet. 1981 Jun 13;1(8233):1305–1307. doi: 10.1016/s0140-6736(81)92471-5. [DOI] [PubMed] [Google Scholar]
  4. Jensen H. E., Amdrup E., Christiansen P., Fenger C., Lindskov J., Nielsen J., Nielsen S. A. Bleeding gastric ulcer. Surgical and non-surgical treatment of 225 patients. Scand J Gastroenterol. 1972;7(6):535–540. doi: 10.3109/00365527209180952. [DOI] [PubMed] [Google Scholar]
  5. Jorgensen T. G. Drug consumption before perforation of peptic ulcer. Br J Surg. 1977 Apr;64(4):247–249. doi: 10.1002/bjs.1800640406. [DOI] [PubMed] [Google Scholar]
  6. McKay A. J., McArdle C. S. Cimetidine and perforated peptic ulcer. Br J Surg. 1982 Jun;69(6):319–320. doi: 10.1002/bjs.1800690609. [DOI] [PubMed] [Google Scholar]
  7. Negre J. Perforated ulcer in elderly people. Lancet. 1985 Nov 16;2(8464):1118–1119. doi: 10.1016/s0140-6736(85)90699-3. [DOI] [PubMed] [Google Scholar]
  8. Rothmund M., Pitsch W. J., Schicketanz K. H. Hospitalisations- und Operationsfrequenz wegen Ulkuskrankheit 1970-1981. Dtsch Med Wochenschr. 1983 Jun 10;108(23):891–895. doi: 10.1055/s-2008-1069662. [DOI] [PubMed] [Google Scholar]
  9. Somerville K., Faulkner G., Langman M. Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet. 1986 Mar 1;1(8479):462–464. doi: 10.1016/s0140-6736(86)92927-2. [DOI] [PubMed] [Google Scholar]
  10. Walt R., Katschinski B., Logan R., Ashley J., Langman M. Rising frequency of ulcer perforation in elderly people in the United Kingdom. Lancet. 1986 Mar 1;1(8479):489–492. doi: 10.1016/s0140-6736(86)92940-5. [DOI] [PubMed] [Google Scholar]
  11. Watkins R. M., Dennison A. R., Collin J. What has happened to perforated peptic ulcer? Br J Surg. 1984 Oct;71(10):774–776. doi: 10.1002/bjs.1800711012. [DOI] [PubMed] [Google Scholar]
  12. Wilson-Macdonald J., Mortensen N. J., Williamson R. C. Perforated gastric ulcer. Postgrad Med J. 1985 Mar;61(713):217–220. doi: 10.1136/pgmj.61.713.217. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES