Abstract
The protease inhibitors, Epsilon Amino Caproic Acid (E.A.C.A.) and Aprotinin were found to significantly increase the inhibition produced by P.P.D. in the Leucocyte Migration Test (L.M.T.). Dose-response curves showed that the most effective concentrations were for E.A.C.A. 0.01 M and Aprotinin 100 I.U./ml. In a series of 29 subjects with a range of Heaf reactivity this finding was consistent providing that there was a significant inhibition to P.P.D. alone. At these concentrations, cell viability was unaffected and the effect of the drugs could be reversed by washing. The exact mode of action of these inhibitors in the L.M.T. requires further elucidation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Soborg M., Bendixen G. Human lymphocyte migration as a parameter of hypersensitivity. Acta Med Scand. 1967 Feb;181(2):247–256. doi: 10.1111/j.0954-6820.1967.tb07255.x. [DOI] [PubMed] [Google Scholar]
- Thornes R. D., Smyth H., Browne O., O'Gorman M., Reen D. J., Farrell D., Holland P. D. The effects of proteolysis on the human immune mechanism in cancer. A preliminary communication. J Med. 1974;5(1):92–97. [PubMed] [Google Scholar]