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. 1988 Jun;72(3):465–469.

Proteins responsible for anticentromere activity found in the sera of patients with CREST-associated Raynaud's phenomenon.

L Kremer 1, J M Alvaro-Gracia 1, C Ossorio 1, J Avila 1
PMCID: PMC1541578  PMID: 3048807

Abstract

Anticentromere antibodies (ACA) present in a high percentage of patients with complete or incomplete CREST scleroderma, and which are presently used in the diagnosis of this disease, also appear in some primary Raynaud's phenomenon patients. Three principal centromeric antigens, CENP-A, CENP-B and CENP-C, have been described as reacting with the sera of these individuals. We attempt to determine whether or not a correlation between the presence of ACA and serum reactivity against one or more of these peptides could be established, and have observed that CENP-A, but not CENP-B or CENP-C, is specifically recognized by all patients sera tested. The fact that this reactivity is clearly detectable at very high serum dilutions, thus eliminating other non-specific interference, suggests that anti-CENP-A activity might be useful in the diagnosis of patients with CREST-associated Raynaud's phenomenon.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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