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. 1977 Jan;30(1):76–80. doi: 10.1136/jcp.30.1.76

The 15 g D-xylose absorption test: its application to the study of coeliac disease.

F M Stevens, D W Watt, M A Bourke, B McNicholl, P F Fottrell, C F McCarthy
PMCID: PMC476650  PMID: 320232

Abstract

The absorption of xylose following an oral load of 15 g D-xylose has been studied by serial blood levels in 17 untreated adult coeliac patients, 21 treated coeliac patients, and 30 non-coeliac patients. A statistically significant difference in xylose blood levels was found between untreated coeliac and non-coeliac patients at all the times studied, but a complete separation between these two groups occurred only at the 75 minute stage. The reproducibility of absorption was assessed by repeating the test in 16 subjects. The 95% confidence limits of the standard error of estimate are narrowest at 75 and 90 minutes.

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Selected References

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  1. BENSON J. A., Jr, CULVER P. J., RAGLAND S., JONES C. M., DRUMMEY G. D., BOUGAS E. The d-xylose absorption test in malabsorption syndromes. N Engl J Med. 1957 Feb 21;256(8):335–339. doi: 10.1056/NEJM195702212560802. [DOI] [PubMed] [Google Scholar]
  2. CHANARIN I., BENNETT M. C. Absorption of folic acid and D-xylose as tests of small-intestinal function. Br Med J. 1962 Apr 7;1(5283):985–989. doi: 10.1136/bmj.1.5283.985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cooke A. R. The stimultaneous emptying and absorption of ethanol from the human stomach. Am J Dig Dis. 1970 May;15(5):449–454. doi: 10.1007/BF02283874. [DOI] [PubMed] [Google Scholar]
  4. Cornell H. J., Townley R. R. The toxicity of certain cereal proteins in coeliac disease. Gut. 1974 Nov;15(11):862–869. doi: 10.1136/gut.15.11.862. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DICKE W. K., WEIJERS H. A., VAN DE KAMER J. H. Coeliac disease. II. The presence in wheat of a factor having a deleterious effect in cases of coeliac disease. Acta Paediatr. 1953 Jan;42(1):34–42. doi: 10.1111/j.1651-2227.1953.tb05563.x. [DOI] [PubMed] [Google Scholar]
  6. Elias E., Gibson G. J., Greenwood L. F., Hunt J. N., Tripp J. H. The slowing of gastric emptying by monosaccharides and disaccharides in test meals. J Physiol. 1968 Feb;194(2):317–326. doi: 10.1113/jphysiol.1968.sp008410. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. FORDTRAN J. S., SOERGEL K. H., INGELFINGER F. J. Intestinal absorption of D-xylose in man. N Engl J Med. 1962 Aug 9;267:274–279. doi: 10.1056/NEJM196208092670602. [DOI] [PubMed] [Google Scholar]
  8. Goldstein F., Karacadag S., Wirts C. W., Kowlessar O. D. Intraluminal small-intestinal utilization of d-xylose by bacteria. A limitation of the d-xylose absorption test. Gastroenterology. 1970 Sep;59(3):380–386. [PubMed] [Google Scholar]
  9. HUNT J. N. THE DUODENAL REGULATION OF GASTRIC EMPTYING. Gastroenterology. 1963 Aug;45:149–156. [PubMed] [Google Scholar]
  10. Hamilton J. R., McNeill L. K. Childhood celiac disease: response of treated patients to a small uniform daily dose of wheat gluten. J Pediatr. 1972 Nov;81(5):885–893. doi: 10.1016/s0022-3476(72)80538-9. [DOI] [PubMed] [Google Scholar]
  11. Hawkins K. I. Pediatric xylose absorption test: measurements in blood preferable to measurements in urine. Clin Chem. 1970 Sep;16(9):749–752. [PubMed] [Google Scholar]
  12. Hunt J. N., Pathak J. D. The osmotic effects of some simple molecules and ions on gastric emptying. J Physiol. 1960 Dec;154(2):254–269. doi: 10.1113/jphysiol.1960.sp006577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kendall M. J., Nutter S., Hawkins C. F. Testing gluten sensitivity by the xylose test. Lancet. 1972 Mar 25;1(7752):667–668. doi: 10.1016/s0140-6736(72)90466-7. [DOI] [PubMed] [Google Scholar]
  14. Kendall M. J., Schneider R., Cox P. S., Hawkins C. F. Gluten subfractions in coeliac disease. Lancet. 1972 Nov 18;2(7786):1065–1067. doi: 10.1016/s0140-6736(72)92344-6. [DOI] [PubMed] [Google Scholar]
  15. Lamabadusuriya S. P., Packer S., Harries J. T. Limitations of xylose tolerance test as a screening procedure in childhood coeliac disease. Arch Dis Child. 1975 Jan;50(1):34–39. doi: 10.1136/adc.50.1.34. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. McCance R. A., Madders K. The comparative rates of absorption of sugars from the human intestine. Biochem J. 1930;24(3):795–804. doi: 10.1042/bj0240795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Menzies I. S. Intestinal permeability in coeliac disease. Gut. 1972 Oct;13(10):847–847. [PubMed] [Google Scholar]
  18. ROBERTS J. G., BECK I. T., KALLOS J., KAHN D. S. D-Xylose blood-level time-curve as an index of intestinal absorption, with a description of a simplified method for estimation of blood xylose levels. Can Med Assoc J. 1960 Jul 16;83:112–117. [PMC free article] [PubMed] [Google Scholar]
  19. Rolles C. J., Anderson M., McNeish A. S. Confirming persistence of gluten intolerance in children diagnosed as having coeliac disease in infancy. Arch Dis Child. 1975 Apr;50(4):259–263. doi: 10.1136/adc.50.4.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Rolles C. J., Kendall M. J. Gluten provocation and the xylose test in adolescents. Lancet. 1973 Aug 18;2(7825):381–381. doi: 10.1016/s0140-6736(73)93227-3. [DOI] [PubMed] [Google Scholar]
  21. Rolles C. J., Nutter S., Kendall M. J., Anderson C. M. One-hour blood-xylose screening-test for coeliac disease in infants and young children. Lancet. 1973 Nov 10;2(7837):1043–1045. doi: 10.1016/s0140-6736(73)92656-1. [DOI] [PubMed] [Google Scholar]
  22. Sladen G. E., Kumar P. J. Is the xylose test still a worth-while investigation? Br Med J. 1973 Jul 28;3(5873):223–226. doi: 10.1136/bmj.3.5873.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. THAYSEN E. H., MULLERTZ S. The D-xylose absorption tolerance test. Acta Med Scand. 1962 May;171:521–529. doi: 10.1111/j.0954-6820.1962.tb04217.x. [DOI] [PubMed] [Google Scholar]
  24. Townley R. R., Cornell H. J., Bhathal P. S., Mitchell J. D. Toxicity of wheat gliadin fractions in coeliac disease. Lancet. 1973 Jun 16;1(7816):1363–1364. doi: 10.1016/s0140-6736(73)91679-6. [DOI] [PubMed] [Google Scholar]
  25. Webster S. G., Leeming J. T. Assessment of small bowel function in the elderly using a modified xylose tolerance test. Gut. 1975 Feb;16(2):109–113. doi: 10.1136/gut.16.2.109. [DOI] [PMC free article] [PubMed] [Google Scholar]

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