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. 1977 May;59(3):222–230.

Lymphocyte depression by cancer.

A J Edwards
PMCID: PMC2491759  PMID: 324338

Abstract

We believe we have shown in the animal model that in cancer the host's lymphoreticular tissues are engaged by a systemically disseminated antilymphocytic humoral factor that destroys the T-cell-dependent pathway, allowing the dissemination of the disease that results in the death of the animal. From studies on patients with cancer there appears to be a real possibility of the presence of a similar substance in man. Such a factor may form the basis for the definiation of cancer and an explanation of cancer illness on the runt hypothesis. Moreover, if the factor could be identified and antagonized a major therapeutic advantage would be achieved.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BILLINGHAM R. E., BRENT L. A simple method for inducing tolerance of skin homografts in mice. Transplant Bull. 1957 Apr;4(2):67–71. [PubMed] [Google Scholar]
  2. Bloom B. R., Bennett B. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science. 1966 Jul 1;153(3731):80–82. doi: 10.1126/science.153.3731.80. [DOI] [PubMed] [Google Scholar]
  3. Cooperband S. R., Bondevik H., Schmid K., Mannick J. A. Transformation of human lymphocytes: inhibition by homologous alpha globulin. Science. 1968 Mar 15;159(3820):1243–1244. doi: 10.1126/science.159.3820.1243. [DOI] [PubMed] [Google Scholar]
  4. Edwards A. J., Rowland G. F., Lee M. R. Reduction of lymphocyte transformation by a factor produced by gastrointestinal cancer. Lancet. 1973 Mar 31;1(7805):687–689. doi: 10.1016/s0140-6736(73)91477-3. [DOI] [PubMed] [Google Scholar]
  5. Edwards A. J., Rowland G. F., Sumner M. R., Hurd C. M. Changes in lymphoreticular tissues during growth of a murine adenocarcinoma. II. Nucleic acid content and synthesis in lymph nodes, spleen, and thymus. J Natl Cancer Inst. 1971 Aug;47(2):313–320. [PubMed] [Google Scholar]
  6. Edwards A. J., Sumner M. R., Rowland G. F., Hurd C. M. Changes in lymphoreticular tissues during growth of a murine adenocarcinoma. I. Histology and weight of lymph nodes, spleen, and thymus. J Natl Cancer Inst. 1971 Aug;47(2):301–311. [PubMed] [Google Scholar]
  7. Edwards A. The response of the reticulo-endothelial system to a cancer. Br J Surg. 1966 Oct;53(10):874–880. doi: 10.1002/bjs.1800531014. [DOI] [PubMed] [Google Scholar]
  8. Eilber F. R., Morton D. L. Impaired immunologic reactivity and recurrence following cancer surgery. Cancer. 1970 Feb;25(2):362–367. doi: 10.1002/1097-0142(197002)25:2<362::aid-cncr2820250213>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  9. Hagen C., Froland A., Weberg E. Lymphocyte transformation in cancer patients. Lancet. 1972 Jun 17;1(7764):1340–1340. doi: 10.1016/s0140-6736(72)91069-0. [DOI] [PubMed] [Google Scholar]
  10. Hellström I., Hellström K. E., Pierce G. E., Yang J. P. Cellular and humoral immunity to different types of human neoplasms. Nature. 1968 Dec 28;220(5174):1352–1354. doi: 10.1038/2201352a0. [DOI] [PubMed] [Google Scholar]
  11. Hellström K. E., Hellström I. Immunological enhancement as studied by cell culture techniques. Annu Rev Microbiol. 1970;24:373–398. doi: 10.1146/annurev.mi.24.100170.002105. [DOI] [PubMed] [Google Scholar]
  12. KALISS N. Immunological enhancement of tumor homografts in mice: a review. Cancer Res. 1958 Oct;18(9):992–1003. [PubMed] [Google Scholar]
  13. Lewis M. G., Ikonopisov R. L., Nairn R. C., Phillips T. M., Fairley G. H., Bodenham D. C., Alexander P. Tumour-specific antibodies in human malignant melanoma and their relationship to the extent of the disease. Br Med J. 1969 Sep 6;3(5670):547–552. doi: 10.1136/bmj.3.5670.547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  15. Morton D. L., Malmgren R. A., Holmes E. C., Ketcham A. S. Demonstration of antibodies against human malignant melanoma by immunofluorescence. Surgery. 1968 Jul;64(1):233–240. [PubMed] [Google Scholar]
  16. Park S. K., Brody J. I., Wallace H. A., Blakemore W. S. Immunosuppressive effect of surgery. Lancet. 1971 Jan 9;1(7689):53–55. doi: 10.1016/s0140-6736(71)90777-x. [DOI] [PubMed] [Google Scholar]
  17. Roberts M. M., Jones-Williams W. The delayed hypersensitivity reaction in breast cancer. Br J Surg. 1974 Jul;61(7):549–552. doi: 10.1002/bjs.1800610713. [DOI] [PubMed] [Google Scholar]
  18. Roberts M. M. Lymphocyte transformation in breast cancer. Br J Surg. 1970 May;57(5):381–381. [PubMed] [Google Scholar]
  19. Roitt I. M., Greaves M. F., Torrigiani G., Brostoff J., Playfair J. H. The cellular basis of immunological responses. A synthesis of some current views. Lancet. 1969 Aug 16;2(7616):367–371. doi: 10.1016/s0140-6736(69)92712-3. [DOI] [PubMed] [Google Scholar]
  20. Rowland G. F., Edwards A. J., Hurd C. M., Sumner M. R. Changes in lymphoreticular tissues during growth of a murine adenocarcinoma. 3. Plaque-forming cell response in lymph nodes and spleen. J Natl Cancer Inst. 1971 Aug;47(2):321–327. [PubMed] [Google Scholar]
  21. Rowland G. F., Edwards A. J., Sumner M. R., Hurd C. M. Thymic dependency of tumor-induced immunodepression. J Natl Cancer Inst. 1973 May;50(5):1329–1336. doi: 10.1093/jnci/50.5.1329. [DOI] [PubMed] [Google Scholar]
  22. Rowland G. F., Hurd C. M. Target lymphoid cell population of carcinogen induced immunodepression in mice. Nature. 1970 Jul 11;227(5254):167–168. doi: 10.1038/227167a0. [DOI] [PubMed] [Google Scholar]
  23. Segall A., Weiler O., Genin J., Lacour J., Lacour F. In vitro study of cellular immunity against autochthonous human cancer. Int J Cancer. 1972 Mar 15;9(2):417–425. doi: 10.1002/ijc.2910090221. [DOI] [PubMed] [Google Scholar]
  24. Silk M. Effect of plasma from patients with carcinoma on in vitro lymphocyte transformation. Cancer. 1967 Dec;20(12):2088–2089. doi: 10.1002/1097-0142(196712)20:12<2088::aid-cncr2820201205>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  25. Southam C. M. The immunologic status of patients with nonlymphomatous cancer. Cancer Res. 1968 Jul;28(7):1433–1440. [PubMed] [Google Scholar]
  26. Sutherland R. M., Inch W. R., McCredie J. A. Phytohemagglutinin (PHA)-induced transformation of lymphocytes from patients with cancer. Cancer. 1971 Mar;27(3):574–578. doi: 10.1002/1097-0142(197103)27:3<574::aid-cncr2820270310>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  27. Whittaker M. G., Rees K., Clark C. G. Reduced lymphocyte transformation in breast cancer. Lancet. 1971 May 1;1(7705):892–893. doi: 10.1016/s0140-6736(71)92448-2. [DOI] [PubMed] [Google Scholar]
  28. Wybran J., Fudenberg H. H. Thymus-derived rosette-forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections, and other diseases. J Clin Invest. 1973 May;52(5):1026–1032. doi: 10.1172/JCI107267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. al-Sarraf M., Vaitkevicius V. K. Effect of homologous plasma on lymphocyte transformation in cancer patients and controls. Lancet. 1971 Aug 7;2(7719):314–315. doi: 10.1016/s0140-6736(71)91357-2. [DOI] [PubMed] [Google Scholar]

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