To the Editor,
We would like to share ideas on the publication “Post-COVID-19 syndrome and humoral response association after one year in vaccinated and unvaccinated patients [1].” Peghin et al. stated that their findings support the routine administration of three mRNA vaccine doses to adolescents and young adults [1]. Over a year after acute infection, the SARS-CoV-2 immunization is not linked to the appearance of post–COVID-19 symptoms [1]. The persistence of strong serological titres responses caused by spontaneous infection but not by vaccination, according to Peghin et al., may play a role in long COVID-19 [1]. We concur that the immunological response to COVID-19 and COVID-19 immunization could play a role in clinical outcomes. The current study can vouch for the vaccine's safety. The confounding effect of the asymptomatic COVID-19 is a relevant concern in the current investigation. Asymptomatic COVID-19 is not uncommon, and it can go unnoticed if not investigated [2]. Asymptomatic COVID-19 can arise during a one-year period. If there is a post-vaccination or post–COVID-19 asymptomatic reinfection, the results of the current study may be difficult to interpret.
Transparency declaration
The authors declare that they have no conflict of interest.
Editor: L Leibovici
References
- 1.Peghin M., De Martino M., Palese A., Gerussi V., Bontempo G., Graziano E., et al. Post-COVID-19 syndrome and humoral response association after one year in vaccinated and unvaccinated patients. Clin Microbiol Infect. 2022 doi: 10.1016/j.cmi.2022.03.016. [Epub head of print] [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Joob B., Wiwanitkit V. Letter to the editor: coronavirus disease 2019 (COVID-19), infectivity, and the incubation period. J Prev Med Public Health. 2020;53:70. doi: 10.3961/jpmph.20.065. [DOI] [PMC free article] [PubMed] [Google Scholar]