Abstract
A preliminary investigation was made into the effect of fourth-stage Strongylus vulgaris larvae sequestered in the tunica media of ileocolic arteries of pony foals treated with ivermectin. The foals had been reared parasite-free, inoculated with infective larvae and given orally a placebo or ivermectin paste. Two foals received subsequently one or two further inoculations with larvae and treatment with ivermectin. Arteriography was used to identify the lesions in the ileocolic artery following inoculation and their regression following treatment. At necropsy, foals were examined for lesions and larvae grossly and histologically. Ivermectin was highly effective against fourth-stage larvae and those present in the media appeared not to unduly affect the integrity of the ileocolic artery. Increased numbers of larvae were not found in the media of foals receiving repeat inoculations and repeat treatments. Larvae were not found in the media of foals treated with a placebo. The major pathological changes in the arterial wall of all foals were attributed to infection with S. vulgaris and there was no strong tendency for the damaged arteries to return to normal after the S. vulgaris were removed.
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- Klei T. R., Torbert B. J., Chapman M. R., Turk M. A. Efficacy of ivermectin in injectable and oral paste formulations against eight-week-old Strongylus vulgaris larvae in ponies. Am J Vet Res. 1984 Jan;45(1):183–185. [PubMed] [Google Scholar]
- Slocombe J. O., McCraw B. M. Controlled tests of ivermectin against migrating Strongylus vulgaris in ponies. Am J Vet Res. 1981 Jun;42(6):1050–1051. [PubMed] [Google Scholar]
- Slocombe J. O., McCraw B. M. Evaluation of ivermectin against later fourth-stage Strongylus vulgaris in ponies at two and five weeks after treatment. Can J Comp Med. 1984 Oct;48(4):343–348. [PMC free article] [PubMed] [Google Scholar]
- Slocombe J. O., McCraw B. M. Evaluation of pyrantel pamoate, nitramisole and avermectin B1a against migrating Strongylus vulgaris larvae. Can J Comp Med. 1980 Jan;44(1):93–100. [PMC free article] [PubMed] [Google Scholar]
- Slocombe J. O., McCraw B. M., Pennock P. W., Baird J. D. Effectiveness of fenbendazole against later 4th-stage Strongylus vulgaris in ponies. Am J Vet Res. 1983 Dec;44(12):2285–2289. [PubMed] [Google Scholar]
- Slocombe J. O., McCraw B. M., Pennock P. W., Vasey J. Effectiveness of ivermectin against later 4th-stage Strongylus vulgaris in ponies. Am J Vet Res. 1982 Sep;43(9):1525–1529. [PubMed] [Google Scholar]
- Slocombe J. O., McCraw B. M., Pennock P., Ducharme N. G., Baird J. D. Effectiveness of oxfendazole against early and later 4th-stage Strongylus vulgaris in ponies. Am J Vet Res. 1986 Mar;47(3):495–500. [PubMed] [Google Scholar]
- Slocombe J. O., Rendano V. T., Owen R. R., Pennock P. W., McCraw B. M. Arteriography in ponies with Strongylus vulgaris arteritis. Can J Comp Med. 1977 Apr;41(2):137–145. [PMC free article] [PubMed] [Google Scholar]