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PLOS One logoLink to PLOS One
. 2023 Jun 27;18(6):e0287742. doi: 10.1371/journal.pone.0287742

Quality, productivity, and economic implications of exoskeletons for occupational use: A systematic review

Daniel E Fournier 1,#, Marcus Yung 1,#, Kumara G Somasundram 1,#, Bronson B Du 1,#, Sara Rezvani 1,#, Amin Yazdani 1,2,*,#
Editor: Noman Naseer3
PMCID: PMC10298758  PMID: 37368889

Abstract

The objective of this systematic review was to synthesize the current state of knowledge on the quality and productivity of workers and their work while wearing exoskeletons, as well as the economic implications of exoskeletons for occupational use. Following the PRISMA guidelines, six databases were systematically searched for relevant journal articles, written in English, and published since January 2000. Articles meeting the inclusion criteria had their quality assessed using JBI’s Checklist for Quasi-Experimental Studies (Non-Randomized Experimental Studies). A total of 6,722 articles were identified and 15 articles focusing on the impact of exoskeletons on quality and productivity of exoskeleton users while performing occupational tasks were included in this study. None of the included articles evaluated the economic implications of exoskeletons for occupational use. This study revealed several quality and productivity measures (e.g., endurance time, task completion time, number of errors, number of task cycles completed) used to evaluate the impact of exoskeletons. The current state of the literature suggests that quality and productivity impacts of exoskeleton use are dependent on task characteristics that should be considered when adopting exoskeletons. Future studies should evaluate the impact of exoskeleton use in the field and on a diverse pool of workers, as well as its economic implications to better support decision-making in the adoption of exoskeletons within organizations.

1. Introduction

An exoskeleton is defined as “a wearable device that augments, enables, assists, or enhances motion, posture, or physical activity” [1]. Exoskeletons have been used for occupational [2] and rehabilitation [3] purposes. Exoskeletons can be classified by type (i.e., active or passive) and by which body part is being supported (i.e., lower body, upper body, full-body) [4]. Active exoskeletons consist of external actuators such as electric motors, hydraulic actuators, and pneumatic muscles to augment the user’s power and provide extra energy [4, 5]. In contrast, passive exoskeletons do not use any actuators. Instead, they rely on elements such as springs and dampers to store and release energy generated by the user’s movements to support a posture or motion at a specific joint [4, 5]. Several previous systematic reviews have provided a comprehensive review on the efficacy of different types of exoskeletons in both industrial applications (e.g., prevention of workplace injuries) and rehabilitative purposes (e.g., functional mobility) [2, 3, 68].

In recent years, there has been a large focus on the development of exoskeletons as a solution to decrease the risk of musculoskeletal disorders (MSD) in the workplace [9, 10]. Work-related MSD, including sprains and strains, are among the most common injuries and represent more than 30% of total claims in Ontario, Canada [11]. Previous research suggests that the use of exoskeletons may mitigate MSD risk by reducing muscle loading and physical stress and strain in work-related tasks [4, 5]. For example, wearing an exoskeleton during a lifting task has been shown to increase metabolic efficiency as well as decrease back muscle activation and low back loading [12].

Despite evidence that generally support the use of exoskeleton for reducing physical exposure and mitigating MSD risk, the health benefits alone may not necessarily facilitate its adoption in organizations. MSD prevention is often treated as an organizational occupational health and safety “side-car”, with inadequate resources that restrict its application [1316]. Hence, ergonomists and/or occupational health and safety professionals may need to spend considerable time to gain credibility and obtain support to implement change [14, 17]. On the other hand, concepts such as quality, productivity, and cost are powerful business agendas [18, 19] that would likely receive more resources and attention. Research has shown that the adoption of exoskeletons is primarily influenced by their impacts on quality and productivity, as well as their economic implications, rather than their potential to reduce MSD risks alone [20, 21]. Exoskeletons are more likely to be adopted if they demonstrate higher impact on quality and productivity [20]; however, they are less likely to be adopted if they are too expensive and have low return on investment [21]. As a result, understanding the impacts of exoskeleton on quality and productivity, as well as its economic implications, can support decision-making in the adoption of exoskeletons in organizations.

To date, no systematic reviews have examined the quality, productivity, and economic impacts of exoskeleton use in occupational tasks. McFarland & Fischer [22] conducted a systematic review of the effects of upper limb exoskeletons on physical exposures. The authors reported on quality and productivity impacts of exoskeleton use; however, this topic was not the primary focus of their review, and did not explicitly include search terms related to quality and productivity. Given the current gaps in the literature, there is a need for more research that directly sheds light on this important topic. Therefore, the objective of our systematic review was to synthesize the current state of knowledge on the quality and productivity of workers and their work while wearing exoskeletons, as well as the economic implications of exoskeletons for occupational use.

2. Methods

2.1. Search strategy

A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify, review and extract data from journal articles [23]. In consultation with research librarians, a list of key words was developed for each of the three concepts: 1) exoskeletons; 2) work and occupation; and 3) quality, productivity, and economics (Table 1). Quality, productivity, and economic terms were adapted from an initial key word list from Hackney et al. [24], which included terms that describe measurable outcomes. The Boolean operators “OR” and “AND” were used between search terms within a concept and across concepts respectively. When available, subject headings for their respective databases were also used in the literature search. An electronic literature search was performed using six databases: PubMed, Medline, Embase, Business Source Complete, IEEE Xplore, and Scopus. The combination of the selected databases helped ensure articles published in scientific journals pertaining to the application of exoskeletons in the medical-, occupational-, engineering-, and business-related fields were captured. Search results were filtered for peer-reviewed journal articles, written in the English language, and published since January 2000. A total of 6,052 articles were identified for screening after 670 duplicates were removed (Fig 1).

Table 1. Search terms used for electronic literature search.

Concept Search Terms
Exoskeleton exoskeleton, exoskeleton device, assistive technology, weight bearing, wearable, device, arm, shoulder, lower body, back, whole body, trunk, support, robotic*
Work & Occupation work*, occupation*, employee*, labour*
Quality, Productivity, and Economics work performance, value, benefit*, cost*, effectiveness, claim*, economic evaluation, operating, job loss, productivity, efficiency, investment, performance, monetary, non-monetary, profit*, return on investment, net present value, job satisfaction, presenteeism, absenteeism, quality, task completion, turnover, impact

*Denotes terms that were searched using all possible suffixes.

Fig 1. PRISMA flow diagram of literature search and screening process for selected articles.

Fig 1

2.2. Selection criteria

We included original research articles that used exoskeleton in occupational tasks and evaluated its effects on quality or productivity of workers and their work, or its economic impacts. For example, we included articles that studied how exoskeletons affected occupational task completion time. Articles were excluded for the following reasons: (a) article was a review paper, (b) article was written in language other than English, (c) exoskeleton was not used in the study, (d) exoskeleton was used for rehabilitation, (e) article measured quality metrics (e.g., electromyography, range of motion, etc.) without relating them to productivity and/or quality, (f) exoskeleton use was not related to a work setting or occupational tasks, and (g) exoskeleton use was not related to quality, productivity, or economic impacts.

2.3. Screening tool

We designed and implemented a screening tool based on the inclusion and exclusion criteria. Titles and abstracts of 300 randomly selected articles were independently screened by five reviewers (DF, BD, KS, MY, AY) to ensure inter-rater reliability with the use of the screening tool. Any discrepancies in the use of the screening tool for inclusion and exclusion between reviewers were discussed until consensus was achieved. Following these discussions, the screening tool was refined to ensure consistent application. Title and abstracts of an additional 30 randomly selected articles were screened by all five reviewers to re-assess the inter-rater reliability of the revised screening tool [25]. After this round of screening, substantial agreement between the five raters was achieved (Fleiss’ kappa value of K = 0.69 [25]). The screening tool is presented in S1 Appendix.

2.4. Title and abstract screening & full-text review

Given substantial reliability with the screening tool for the title and abstract screening (330 articles), the remaining 5722 articles were divided and independently screened by five reviewers based on their titles and abstracts using Covidence software [26]. When a reviewer was unsure of the relevancy of the article, the article was retained for full-text review. Eighty articles were retained after the title and abstract screening and were reviewed in full independently by two reviewers (DF, SR). Any discrepancies between reviewers for inclusion of an article were discussed by both reviewers until consensus was reached. A total of 15 articles were included in the final review and 65 studies were excluded due to: being a review paper (n = 11), full-text written in language other than English (n = 1), not using an exoskeleton (n = 17), using an exoskeleton for rehabilitation (n = 1), not linking exoskeleton use to a work setting or occupational tasks (n = 9), and not linking exoskeleton use to quality, productivity, or economic impacts (n = 26).

2.5. Quality appraisal & data extraction

Two reviewers (DF, SR), who completed the full-text review, independently assessed the quality of the 15 articles included in the final review using the JBI Critical Appraisal Tools [27]. JBI Checklist for Quasi-Experimental Studies (Non-Randomized Experimental Studies) included nine questions and was used to appraise quasi-experimental studies [27]. The research team determined a cut off value of 6, a priori, as an acceptable score to assess the articles as good quality [28, 29]. The score of each article was calculated based on the number of components included from the checklist. A consensus-based decision was reached by the two reviewers for each article and any disagreement was resolved through discussion. Following the quality appraisal, data was extracted from each article using a custom data extraction tool in Covidence.

3. Results

We identified 15 articles pertaining to the impact of exoskeletons on quality and productivity of workers and their work. Quality and productivity were evaluated in each study using objective measures. No articles assessed the economic impact (e.g., cost, return on investment) of exoskeletons.

Extracted data included: characteristics of each article (i.e., author, year, country, study design, participant description, and quality appraisal score) (Table 2); exoskeleton characteristics, occupational tasks performed, as well as quality and productivity measures and results (Table 3). Fifteen unique brands and types of exoskeletons were described in the included articles, consisting of 1 active exoskeleton, 12 passive exoskeletons, 1 wearable robot suit, and 1 exoskeleton where the type was not reported. Thirteen studies evaluated exoskeletons in a laboratory setting and simulated tasks such as drilling, manual material handling, manual assembly, and military operations. The remaining two studies evaluated exoskeleton use in a realistic setting such as snow shoveling, welding, and electrostatic painting. All articles received a score of 6 or more on the Checklist for Quasi-Experimental Studies (Non-Randomized Experimental Studies), indicating good quality.

Table 2. Article characteristics of included research papers (sorted by year).

Author, Year Country Study Design Participant Sample Size and Description Quality Appraisal Score
Bosch et al., 2016 [30] Netherlands Repeated measures laboratory study 18 (9M, 9F) Healthy Adults 8
Butler, 2016 [31] USA Repeated measures field study 4a (2 Welders, 2 Painters) 6
Kim et al., 2018 [9] USA Repeated measures laboratory study 12 (6M, 6F) University Students & Community Members 7
Miura et al., 2018 [32] Japan Repeated measures field study 9 All Healthy Males 7
Miura et al., 2018 [33] Japan Repeated measures laboratory study 18 (11M, 7F) Healthy Adults 8
Alabdulkarim et al., 2019 [34] USA Repeated measures laboratory study 12 (7M, 5F) University Students & Community Members 8
Bequette et al., 2020 [35] USA Repeated measures laboratory study 12 Military, All Healthy Males 8
Gruevski et al., 2020 [36] Canada Repeated measures laboratory study 2 Canadian Infantry Regular Force Unit, All Healthy Males 8
Madinei et al., 2020 [37] USA Repeated measures laboratory study 18 (9M, 9F) University Students & Community Members 8
Maurice et al., 2020 [38] Slovenia Repeated measures laboratory study 12 College Students, All Healthy Males 8
Luger et al., 2021 [39] Germany Repeated measures laboratory study 36 (2 excluded) All Healthy Males 8
Ogunseiju et al., 2022 [40] USA Repeated measures laboratory study 10a Students 8
De Bock et al., 2022 [10] Belgium Repeated measures laboratory study 22 All Healthy Males 8
Garosi et al., 2022 [41] Iran Repeated measures laboratory study 14 University Students, All Healthy Males 8
Pinho & Forner-Cordero, 2022 [42] Brazil Repeated measures laboratory study 14 (12M, 2F) Automotive Industry Workers 8

Note: M = males; F = females

a Distribution of sex was not specified.

Table 3. Exoskeleton brand and type, occupational tasks performed, as well as quality and performance measures and results (sorted by year).

Author, Year Exoskeleton Brand Exoskeleton Type Occupational Tasks Performed Quality & Productivity Measures Quality & Productivity Results
Bosch et al., 2016 [30] Laevo Passive exoskeleton Static trunk forward flexion with both arms hanging down vertically Endurance time (min) ↑ endurance time
Butler, 2016 [31] “Personal Ergonomic Device” (PED) Not reported • Electrostatic Painting
• Welding
• Electrostatic Painting: light pain and runs, film thickness, transfer efficiency, dry thickness, and time to paint
• Welding: position, contact tip work distance, work angle, travel angle and travel speed, and total weld time
↑ quality and productivity
Note: no statistical tests were conducted to detect significant differences
Kim et al., 2018 [9] EksoVest (prototype) Passive upper extremity exoskeletal vest • Repetitive drilling task at different work heights (overhead and shoulder heights)
• Light assembly task (wiring task) at different work heights
• Number of errors
• Task completion time (s)
• ↑ number of errors in overhead drilling
• ↓ drilling task completion time, regardless of work height
• Ø wiring task completion time
Miura et al., 2018 [32] HAL–hybrid assisted limb for Care Support Wearable robot suit for lumbar support Snow-shoveling • Number of scoops
• Shoveling endurance time (s)
• Shoveling distance (m)
↑ number of scoops, shoveling endurance time, and shoveling distance
Miura et al., 2018 [33] HAL–hybrid assisted limb for Care Support Wearable robot suit for lumbar support Repetitive lifting task • Number of lifts
• Lifting endurance time (s)
↑ number of lifts and lifting endurance time
Alabdulkarim et al., 2019 [34] 1. Exovest
2. EksoWorks 3. FORTIS
1. Passive upper extremity exoskeleton vest
2. Passive upper extremity exoskeleton vest
3. Passive full-body exoskeleton
Overhead repetitive drilling task Number of errors ↑ number of errors when using the Exovest and FORTIS exoskeletons
Bequette et al., 2020 [35] “Lower-extremity exoskeleton” (10kg) Active lower-extremity exoskeleton • Visual task: respond to light targets by pressing a button on a simulated rifle
• Auditory task: answering simulated radio calls
• Follow task: follow researcher at a specified distance
• Visual task: number of misses and visual reaction time (s)
• Auditory task: number of misses and auditory reaction time (s)
• Follow task: incremental lag time (s)
• ↑ reaction time in visual task with powered exoskeleton than without exoskeleton for 5 of 12 participants
• ↑ reaction time in auditory task with powered exoskeleton than unpowered exoskeleton for all participants
• Ø number of misses in visual and auditory tasks
• ↑ incremental lag time in follow task with unpowered exoskeleton than powered/without exoskeleton for 1 participant
Gruevski et al., 2020 [36] UPRISE Gen 3.0 (customized prototype) Passive full-body exoskeleton Can-LEAP obstacle course, that consists of 10 obstacles such as sprint, agility run, crawls, casualty drag, etc Task completion time (s) • ↑ total obstacle course completion time
• Ø completion time for running or carrying tasks
• ↑ completion time for tasks with confined spaces
Note: no statistical tests were conducted to detect significant differences
Madinei et al., 2020 [37] 1. BackX (model AC)
2. Laevo V2.5
1. Passive back-support exoskeletons
2. Passive back-support exoskeleton
Precision manual assembly task (insert pegs in a pegboard) in seated and unseated positions Completion time (s) • ↑ task completion time with the use of BackX and Laevo for females during seated and unseated positions
• ↑ task completion time with the use of BackX for males during unseated position
Maurice et al., 2020 [38] PAEXO Passive upper-limb exoskeleton Overhead pointing task with a power drill
Duration of movement (s) Ø movement duration
Luger et al., 2021 [39] Laevo V2.56 (2.8kg) Passive back-support exoskeleton • Pallet box lifting
• Fastening screws
• Lattice box lifting
Time-to-task-accomplishment (s) ↑ time-to-task-accomplishment for pallet box lifting and lattice box lifting
Ø time-to-task-accomplishment for fastening screws
Ogunseiju et al., 2022 [40] FLx ErgoSkeleton Passive postural-assist exoskeleton Manual material handling tasks: lifting, moving, and placing wooden planks
Completion time (s) Ø task completion time
De Bock et al., 2022 [10] Exo4Work Passive cable-driven shoulder exoskeleton • Wiring
• Drilling
• Lifting
• Number of wires connected
• Drilling force precision (N)
• Lifting task completion time (s)
• Ø number of wires connected and drilling force precision
• ↑ completion time of one lifting cycle
Garosi et al., 2022 [41] “Head/neck supporting exoskeleton” (HNSE) Passive head/neck supporting exoskeleton Repetitive fastening/unfastening nut task at overhead work height
Number of fastened/unfastened nuts Ø number of nuts fastened/unfastened
Pinho & Forner-Cordero, 2022 [42] ShoulderX (V1) Passive upper-limb exoskeleton Manual screwing/unscrewing task at different work heights Task completion time (s) ↑ task completion time at shoulder height

Note: ↑ or ↓ = increase or decrease with exoskeleton use compared to without exoskeleton; Ø no difference between with and without exoskeleton. Results are statistically significant unless otherwise specified.

3.1. Quality

Five studies assessed the impacts of exoskeleton on quality measures in occupational tasks such as simulated drilling (n = 3), simulated military operations (n = 1), and welding and electrostatic painting (n = 1) (Table 3). Metrics of quality included number of errors (n = 2), precision (n = 1), reaction time (n = 1), number of misses (n = 1), as well as other metrics specific to welding and electrostatic painting (n = 1) (Table 3).

There were mixed findings surrounding the effects of exoskeleton on drilling quality. Impact of exoskeleton on number of errors during repetitive drilling tasks has been shown to depend on work height [9] and design of exoskeleton [34]. When using the exoskeleton in a drilling task, the number of errors increased at overhead height but did not significantly change at shoulder height [9]. Number of errors in overhead drilling increased with the use of a passive upper extremity exoskeleton or a passive full-body exoskeleton; however, there was no significant change in errors when using a different passive upper extremity exoskeleton [34]. Exoskeleton use during overhead drilling did not significantly affect drilling force precision [10].

Positive effects were reported for quality in welding and electrostatic painting when using an exoskeleton [31]. Welders who used an exoskeleton experienced quality improvements in their task when considering several metrics including position, work angle, and travel angle. Exoskeleton use also resulted in greater quality in electrostatic painting based on measures such as visual defects (light pain and runs), film thickness, and dry thickness.

Exoskeleton use demonstrated mixed impacts on quality in a military obstacle course simulation that included visual and auditory tasks [35]. Reaction time in the visual task (i.e., respond to light targets by pressing a button on a simulated rifle) increased in some participants when using a powered exoskeleton. Similarly, reaction time in the auditory task (i.e., answering simulated radio calls) increased in all participants with the powered exoskeleton. Exoskeleton use, however, did not significantly affect the number of misses in both tasks.

3.2. Productivity

Thirteen studies examined the effects of exoskeleton on productivity in occupational tasks such as welding and electrostatic painting (n = 1); simulated military operations (n = 2); shoveling (n = 1); as well as simulated manual material handling, drilling, and/or manual assembly tasks (n = 9) (Table 3). Productivity metrics included task completion time (n = 8); endurance time (n = 3); movement duration (n = 1); number of task cycles completed (n = 4); and other metrics specific to shoveling (n = 1), military operations (n = 1), as well as welding and electrostatic painting (n = 1) (Table 3).

Exoskeleton use positively affected productivity in shoveling as well as welding and electrostatic painting. Number of scoops, shoveling endurance time, and shoveling distance increased with exoskeleton use [32]. When using an exoskeleton, welders demonstrated higher productivity according to metrics such as contact tip work distance, travel speed, and total weld time [31]. Similarly, exoskeleton use improved productivity in electrostatic painting based on measures such as transfer efficiency and time to paint.

There were mixed findings regarding the effects of exoskeleton on productivity in military obstacle course simulations. When using a passive full-body exoskeleton, completion time increased in tasks with confined spaces but did not significantly change in running or carrying tasks during the simulation [36]. Additionally, when military personnel were instructed to follow a researcher at a specified distance, only one of 12 participants demonstrated longer incremental lag time with the use of an unpowered lower-extremity exoskeleton [35].

The literature revealed mixed evidence on the productivity impacts of exoskeleton in simulated manual material handling, drilling, and manual assembly tasks. Lifting endurance time and number of lifts in a repetitive lifting task increased with exoskeleton use [33]; however, task completion time was either longer [10, 39] or did not significantly change [40] when using exoskeletons. Exoskeleton use has been shown to reduce completion time in a drilling task, regardless of work height [9]; however, it did not significantly affect movement duration during an overhead pointing task with a power drill [38]. Using an exoskeleton in manual assembly tasks, such as connecting wires and fastening nuts or screws, did not significantly alter task completion time [9, 39] and number of task cycles completed [10, 41]; however, it negatively affected completion time in a manual screwing task at shoulder height [42]. Interestingly, one study demonstrated that the impact of two passive back-support exoskeletons on completion time in a simulated manual assembly task (i.e., inserting pegs in a pegboard) was dependent on the sex of the participant during different seating conditions [37]. Madinei et al. (2020) [37] found that task completion time increased for females when using either of the two passive back-support exoskeletons in seated and unseated positions, whereas for males, only one of the exoskeletons resulted in a longer completion time in unseated positions. A passive back-support exoskeleton has also been shown to improve endurance time when participants were instructed to maintain a forward trunk flexion in a simulated manual assembly setup [30].

4. Discussion

In this systematic review, we synthesized the current state of knowledge on the quality and productivity of workers and their work while wearing exoskeletons, as well as the economic implications of exoskeletons for occupational use. Based on 15 articles, we observed mixed evidence in the current literature regarding the quality and productivity impacts of exoskeleton use. None of the included articles assessed the economic impacts of exoskeletons.

There was mixed evidence regarding the quality and productivity impacts of exoskeleton use reported in the analyzed literature; this finding was irrespective of the type of exoskeleton (passive vs. active), the brand of exoskeleton, and the supported body part(s). Although the literature reported mixed results across all types and brands of exoskeletons, their effectiveness was dependent on task characteristics (e.g., static vs. dynamic movements, workspace, etc.). For example, using a passive exoskeleton increased endurance time for tasks requiring static postures like forward trunk flexion to be held [30]. However, the same exoskeleton would potentially not be as effective for dynamic tasks such as manual material handling due to its negative impact on task completion time [39].

None of the articles evaluated the economic implications of exoskeletons for occupational use. Studies analyzing economic impacts of occupational health and safety interventions in the workplace have been generally rare [43, 44]. The lack of studies may be due to workplace challenges (e.g., insufficient financial data available from organizations, conflicting priorities among stakeholders, etc.) and limited expertise in economic analysis among health and safety researchers [43]. Economic impacts of exoskeletons can have a strong influence on their implementation in organizations [21]. Developing resources based on research evidence in peer reviewed publications on the financial implications of exoskeletons will provide crucial evidence and data for the adoption and uptake of these technologies by organizations.

The current state of the literature also places an emphasis on lab-based studies in comparison to field studies. Out of the 15 articles assessed, only two [31, 32] evaluated the effects of exoskeleton on quality and productivity in the field. Job dynamics in actual work environments are more complex than lab settings [45]. Factors such as safety and working conditions (e.g., personal protective equipment, weather condition, confined spaces) may also influence the effectiveness of exoskeletons in the field and cannot be fully replicated in a lab environment [37].

Out of the 15 articles evaluated in this systematic review, only five studies [9, 30, 33, 34, 37] included women as part of the study population, and out of the five, only two articles [34, 37] analyzed gender differences. Lack of a diverse study population in most of the included articles may limit the generalizability of their results. Sex and gender differences were not often considered likely because the majority of occupations that may potentially benefit from exoskeleton implementation were male-dominated jobs [46]. However, in many sectors including the skilled trades, there is a significant focus on diversifying the workforce to counter the current nationwide shortage of skilled labour [47].

4.1. Recommendations for future studies

Based on the findings of our systematic review, we propose several recommendations for future studies. Future research on exoskeletons should focus on assessing quality and productivity of workers as we only found 15 articles; most importantly, as our research did not yield articles evaluating the economic implication of exoskeletons, future research should focus on cost-benefit analysis and return on investment to justify the benefits of exoskeleton adoption for the organization and its workers. Evaluation studies have been primarily lab-based, limiting their ecological validity; we encourage researchers to evaluate exoskeletons with actual workers while completing their job tasks on worksites. Furthermore, the participants in future research studies should reflect the emerging diverse workforce including women and people from underrepresented groups. Without more information on the impacts of exoskeleton use in real work environments and on a diverse work population as well as its economic implications, these gaps in the literature will continue to hinder organizations from adopting exoskeletons and may limit the full potential and application of these technologies.

4.2. Limitations

There are several limitations to consider for this review. First, literature that may have included some aspects of quality and productivity described above may have been excluded during the screening process, due to poor descriptions in the titles and abstracts. In order to capture all potential articles, the reviewers included articles they were unsure of for full-text review if the title and abstract did not lead to a conclusive decision. Second, literature prior to January 2000 and conference papers were excluded since the inclusion criteria required original peer-reviewed journal articles. However, this is a common limitation as conference abstracts often contain information that may be inadequate and not dependable for inclusion [48]. Third, our literature search was based on an a priori list of selected key words and subject heading terms compiled after consulting with research librarians; however, we may have missed certain search key terms. Different groups assessing the same research question may have arrived at a different list of key words and subject heading terms that may have led to different search results from each database. However, the generated key word list for this systematic review was compiled after a consensus was reached after numerous discussions between the team of authors and librarians. Given the considerable body of evidence from the search, this common limitation would not have affected the results.

4.3. Conclusion

Our systematic review provided mixed evidence regarding the effectiveness of exoskeleton based on quality and productivity measures. We also observed an absence of evidence on the economic impacts (e.g., cost, return on investment) of exoskeletons for occupational use. When selecting and adopting exoskeletons, task characteristics (e.g., required movements, workspace) may need to be considered to achieve the most effective outcomes for quality and productivity of workers and their work. More empirical studies are needed to improve our understanding on quality, productivity, and economic impacts of exoskeletons, including studies that consider sex and gender as well as studies that take place in actual work environments.

Supporting information

S1 Checklist. PRISMA checklist.

(DOC)

S1 Appendix. Screening tool.

(DOCX)

S1 Dataset. Minimal dataset.

(CSV)

Acknowledgments

We would like to acknowledge Danya Goldsmith Milne and Juliet Conlon for their assistance and expertise in compiling the list of key search terms used for this systematic review.

Data Availability

All relevant data are within the paper and its Supporting Information files.

Funding Statement

The research was co-funded by the Social Sciences and Humanities Research Council (SSHRC) and through Natural Sciences and Engineering Research Council under College and Community Social Innovation Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Initials of author who received the award: AY, MY SSHRC Ref.: 970-2021-1007 Funding Agency Website: https://www.sshrc-crsh.gc.ca/home-accueil-eng.aspx.

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Decision Letter 0

Noman Naseer

9 May 2023

PONE-D-23-09205Effects of exoskeleton use on quality and productivity: A systematic reviewPLOS ONE

Dear Dr. Yazdani,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

============================== Associate Editor: Reviewers have raised some concerns that should be addressed. 

==============================

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PLOS ONE

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Additional Editor Comments:

Associate Editor: Reviewers have raised some concerns that should be addressed.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: No

Reviewer #2: Yes

**********

2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: No

Reviewer #2: N/A

**********

3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: In this manuscript authors analyzed the effects of exoskeleton use on Quality and Productivity. For this purpose 15 critical studies were selected and reviewed for the factors/measures of endurance time, task completion time, number of errors, number of task cycles completed etc. Following are the concerns and suggestion to improve the manuscript

1. As per my understanding, the author's intension was to measure the quality and productivity of produced, developed and available exoskeleton in and out of lab applications. For this purpose keywords selected were not focused and had deficiencies, like human power augmentation, HCI based exoskeleton, BCI based exoskeletons, neurorobotics etc. These keyword may provide other critical studies for the mentioned topic.

2. The Introduction section is very brief and lacks a comprehensive review including introduction of exoskeleton, their types and applications. This will help to better contextualize your study and highlight the significance of your research question.

3. Table 3 provides the good insights of the previous studies, however a critical review selected factors/measures is missing to answer the research question. Enhance this section of the manuscript, I recommend to categorize this section with respect to the selected factors/measures and impact on type of exoskeleton. This will help to highlight the strengths and weaknesses of previous research, and provide a clearer picture of how your study contributes to the field.

4. With respect to quality and productivity, commercial exoskeletons were not reviewed and ignored. In order to complete the comprehensive review, commercially available exoskeletons should also be included in the study, this may enhance the contribution of this study and helps to suggest conclusive recommendations.

5. The manuscript does include a brief discussion section, however recommendations are ignored or mixed with discussions. Comprehensive and conclusive findings and recommendations are missing, it is suggested to review all these sections and include additional headings to support the findings and arguments.

Reviewer #2: Overall, the presented paper is satisfactory. However, it is crucial to delve deeper into the factors that influence the quality and productivity outcome measures when utilizing an exoskeleton for occupational tasks. Additionally, it is recommended to review the excluded criteria in the screening step. Please revise them accordingly.

Kindly attach the checklist of questions pertaining to the inclusion criteria of the papers for reference. This will help ensure the selection process is comprehensive and accurate.

Lastly, to enhance the validity of the results, it is advisable to increase the number of papers included in the review. This will provide a more robust foundation for validating the findings.

**********

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Reviewer #1: Yes: Hammad Nazeer

Reviewer #2: No

**********

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PLoS One. 2023 Jun 27;18(6):e0287742. doi: 10.1371/journal.pone.0287742.r002

Author response to Decision Letter 0


24 May 2023

We would like to thank both reviewers for their comments and the academic editor for the opportunity to improve this manuscript. We are pleased that reviewers found this manuscript to be well written and satisfactory. Please see our responses to each comment below.

Reviewer #1: In this manuscript authors analyzed the effects of exoskeleton use on Quality and Productivity. For this purpose 15 critical studies were selected and reviewed for the factors/measures of endurance time, task completion time, number of errors, number of task cycles completed etc. Following are the concerns and suggestion to improve the manuscript

Authors Response: Thank you for your constructive feedback. We believe the following modifications significantly improved the manuscript.

1. As per my understanding, the author's intension was to measure the quality and productivity of produced, developed and available exoskeleton in and out of lab applications. For this purpose keywords selected were not focused and had deficiencies, like human power augmentation, HCI based exoskeleton, BCI based exoskeletons, neurorobotics etc. These keywords may provide other critical studies for the mentioned topic.

Authors Response: Thank you for your comment. The intention of this systematic review was not to evaluate the quality and productivity of exoskeletons themselves. Instead, the purpose of this systematic review was to synthesize the current state of knowledge on the quality and productivity of workers and their work while wearing exoskeletons, as well as the economic implications of exoskeletons for occupational use. For example, we are interested in how the usage of exoskeletons could impact construction or assembly line workers’ quality and productivity of their work while wearing exoskeletons.

In order to avoid possible confusion, we have added some clarification in the Introduction (lines 79-81).

2. The Introduction section is very brief and lacks a comprehensive review including introduction of exoskeleton, their types and applications. This will help to better contextualize your study and highlight the significance of your research question.

Authors Response: Thank you for your feedback. We have added additional information to further clarify the types and applications of exoskeletons (lines 42-43). We have also cited several studies to help readers obtain more in-depth information regarding different types of exoskeletons (lines 48-51).

3. Table 3 provides the good insights of the previous studies, however a critical review selected factors/measures is missing to answer the research question. Enhance this section of the manuscript, I recommend to categorize this section with respect to the selected factors/measures and impact on type of exoskeleton. This will help to highlight the strengths and weaknesses of previous research, and provide a clearer picture of how your study contributes to the field.

Authors Response: Thank you for your feedback. The purpose of our systematic review was to synthesize the current state of knowledge on the quality and productivity of workers and their work while wearing exoskeletons, as well as the economic implications of exoskeletons for occupational use. Performing a critical review of the measures on quality and productivity of exoskeleton products was beyond the scope of our systematic review. We understand that this might be a source of confusion and therefore, in response to your comment, we further clarified our research objective in the Introduction (lines 79-81).

4. With respect to quality and productivity, commercial exoskeletons were not reviewed and ignored. In order to complete the comprehensive review, commercially available exoskeletons should also be included in the study, this may enhance the contribution of this study and helps to suggest conclusive recommendations.

Authors Response: Thank you for your comment. We did not exclude commercial exoskeletons in our search strategy. “Exoskeleton” is one of the terms used in our literature search. Some of the papers that were retained for our review based on our systematic search and screening process, assessed the commercial exoskeletons designed for occupational application such as Laevo, HAL, BackX, and EksoWorks, and some assessed their own proprietary exoskeletons (Table 3).

5. The manuscript does include a brief discussion section, however recommendations are ignored or mixed with discussions. Comprehensive and conclusive findings and recommendations are missing, it is suggested to review all these sections and include additional headings to support the findings and arguments.

Authors Response: Thank you for your feedback. In response to your comment, we have provided recommendations for future studies in the new Section 4.1 to better guide the reader.

We clarified our conclusion in Section 4.3. Our systematic review provided mixed evidence regarding the effectiveness of exoskeleton based on quality and productivity measures. We also observed an absence of evidence on the economic impacts (e.g., cost, return on investment) of exoskeletons for occupational use. When selecting and adopting exoskeletons, task characteristics (e.g., required movements, workspace) may need to be considered to achieve the most effective outcomes for quality and productivity of workers and their work. More empirical studies are needed to improve our understanding on quality, productivity, and economic impacts of exoskeletons, including studies that consider sex and gender as well as studies that take place in actual work environments.

Reviewer #2: Overall, the presented paper is satisfactory. However, it is crucial to delve deeper into the factors that influence the quality and productivity outcome measures when utilizing an exoskeleton for occupational tasks. Additionally, it is recommended to review the excluded criteria in the screening step. Please revise them accordingly.

Authors Response: Thank you for your comment. We appreciate that you found this paper satisfactory.

In this systematic review, our objective was to synthesize the state of knowledge on the quality and productivity of workers and their work while wearing exoskeletons, as well as the economic implications of exoskeletons for occupational use. Assessing the factors that influence the quality and productivity outcome measures was beyond the scope of our systematic review. In response to your comment, we have clarified our inclusion and exclusion criteria in Section 2.2.

Kindly attach the checklist of questions pertaining to the inclusion criteria of the papers for reference. This will help ensure the selection process is comprehensive and accurate.

Authors Response: Thank you for your feedback. We have attached our screening tool in S1 Appendix. It includes the checklist of questions pertaining to the inclusion criteria.

Lastly, to enhance the validity of the results, it is advisable to increase the number of papers included in the review. This will provide a more robust foundation for validating the findings.

Authors Response: Thank you for your comment. We followed the systematic review guidelines and PRISMA checklist to obtain the most relevant research articles pertaining to our research objective. Our search strategy included six large databases (i.e., PubMed, Medline, Embase, Business Source Complete, IEEE Xplore, and Scopus) and we identified 6,722 articles in our initial search. We had to exclude 670 duplicates as well as 6,037 articles because they did not meet the inclusion criteria.

Attachment

Submitted filename: Response to Reviewers.docx

Decision Letter 1

Noman Naseer

14 Jun 2023

Quality, productivity, and economic implications of exoskeletons for occupational use: A systematic review

PONE-D-23-09205R1

Dear Dr. Yazdani,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

An invoice for payment will follow shortly after the formal acceptance. To ensure an efficient process, please log into Editorial Manager at http://www.editorialmanager.com/pone/, click the 'Update My Information' link at the top of the page, and double check that your user information is up-to-date. If you have any billing related questions, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Noman Naseer, PhD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

The comments have been adequetly addressed. The paper is in acceptable form now.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: N/A

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The Authors have addressed all of my concerns with the original manuscript. The revised manuscript is ready for publication.

Reviewer #2: I would like to express my gratitude for submitting the revised version of your manuscript in response to the comments and suggestions provided by the reviewers, including my own. Thank you for taking the time and effort to address the concerns raised and for providing detailed clarifications in the revised manuscript.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

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Reviewer #1: Yes: Hammad Nazeer

Reviewer #2: No

**********

Acceptance letter

Noman Naseer

19 Jun 2023

PONE-D-23-09205R1

Quality, productivity, and economic implications of exoskeletons for occupational use: A systematic review

Dear Dr. Yazdani:

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on behalf of

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Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    S1 Checklist. PRISMA checklist.

    (DOC)

    S1 Appendix. Screening tool.

    (DOCX)

    S1 Dataset. Minimal dataset.

    (CSV)

    Attachment

    Submitted filename: Response to Reviewers.docx

    Data Availability Statement

    All relevant data are within the paper and its Supporting Information files.


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