Abstract
Measurements of the resistance, time constant, and compliance of the respiratory system were made in 25 mechanically ventilated, preterm babies on 32 occasions, using the single breath technique. Patients were classified according to the level of respiratory resistance by reference to a population of 36 babies studied over the first two days of life before airway secretions had become apparent. There was a highly significant fall in both the resistance and time constant measurements after tracheobronchial suction or lavage for infants whose pretreatment values of resistance were greater than the reference mean. When tracheobronchial toilet was effective in removing secretions the changes in resistance and time constant values were again significant. No changes in compliance values were noted. Severe but clinically inapparent mucous obstruction of the airways was revealed in two infants by a progressively rising respiratory system resistance during continuous monitoring. The need for and efficacy of tracheobronchial suction and lavage could be determined by such techniques for monitoring the resistance of the respiratory system during mechanical ventilation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Fox W. W., Schwartz J. G., Shaffer T. H. Pulmonary physiotherapy in neonates: physiologic changes and respiratory management. J Pediatr. 1978 Jun;92(6):977–981. doi: 10.1016/s0022-3476(78)80381-3. [DOI] [PubMed] [Google Scholar]
- Landa J. F., Kwoka M. A., Chapman G. A., Brito M., Sackner M. A. Effects of suctioning on mucociliary transport. Chest. 1980 Feb;77(2):202–207. doi: 10.1378/chest.77.2.202. [DOI] [PubMed] [Google Scholar]
- LeSouef P. N., England S. J., Bryan A. C. Total resistance of the respiratory system in preterm infants with and without an endotracheal tube. J Pediatr. 1984 Jan;104(1):108–111. doi: 10.1016/s0022-3476(84)80605-8. [DOI] [PubMed] [Google Scholar]
- Lesouef P. N., England S. J., Bryan A. C. Passive respiratory mechanics in newborns and children. Am Rev Respir Dis. 1984 Apr;129(4):552–556. [PubMed] [Google Scholar]
- Mortola J. P., Noworaj A. Two-sidearm tracheal cannula for respiratory airflow measurements in small animals. J Appl Physiol Respir Environ Exerc Physiol. 1983 Jul;55(1 Pt 1):250–253. doi: 10.1152/jappl.1983.55.1.250. [DOI] [PubMed] [Google Scholar]
- NEWHOUSE M. T., BECKLAKE M. R., MACKLEM P. T., MCGREGOR M. EFFECT OF ALTERATIONS IN END-TIDAL CO2 TENSION ON FLOW RESISTANCE. J Appl Physiol. 1964 Jul;19:745–749. doi: 10.1152/jappl.1964.19.4.745. [DOI] [PubMed] [Google Scholar]
- Perlman J. M., Volpe J. J. Suctioning in the preterm infant: effects on cerebral blood flow velocity, intracranial pressure, and arterial blood pressure. Pediatrics. 1983 Sep;72(3):329–334. [PubMed] [Google Scholar]
- Stocks J., Thomson A., Silverman M. The numerical analysis of pressure-flow curves in infancy. Pediatr Pulmonol. 1985 Jan-Feb;1(1):19–26. doi: 10.1002/ppul.1950010107. [DOI] [PubMed] [Google Scholar]
- Storm W. Transient bacteremia following endotracheal suctioning in ventilated newborns. Pediatrics. 1980 Mar;65(3):487–490. [PubMed] [Google Scholar]
- Wong Y. C., Beardsmore C. S., Meek J. H., Stocks J., Silverman M. Bronchial hypersecretion in preterm neonates. Arch Dis Child. 1982 Feb;57(2):117–122. doi: 10.1136/adc.57.2.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woodside K. H., Latham S. B., Denas S. M. Increased recovery of neutrophils, macrophages and lymphocytes following repeated lavage of sheep lung in vivo. Exp Lung Res. 1983 Dec;5(4):295–303. doi: 10.3109/01902148309061522. [DOI] [PubMed] [Google Scholar]