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. 1987 Jan;62(1):53–56. doi: 10.1136/adc.62.1.53

Growth hormone response to a standardised exercise test in relation to puberty and stature.

S A Greene, T Torresani, A Prader
PMCID: PMC1778131  PMID: 3813636

Abstract

Growth hormone (GH) was measured before and 10 minutes after a standardised bicycle exercise test (duration 15 minutes) in 37 short children (group 1: mean (SD) age 12.8 (3.5) years; mean (SD) bone age 10.4 (3.6) years; mean (SD) height standard deviation score (SDS) -2.8 (0.7], 16 tall children (group 2: mean age 12.9 (2.8) years; mean bone age 13.9 (1.4) years; mean height SDS 3.0 (0.8], and 30 normal children (group 3: mean age 13.3 (3.2) years; mean bone age 12.8 (3.4) years; mean height SDS -0.4 (0.8]. Results of GH are expressed as mean (SEM). The pre-exercise GH was similar in the three groups (group 1, 8.0 (2.3) mU/l, group 2, 8.5 (2.5) mU/l, and group 3, 8.3 (2.3) mU/l). There was a significant rise in GH after exercise in all three groups. GH after exercise was higher in group 2 (35.1 (2.5) mU/l) compared with groups 1 and 3 (17.8 (3.0) and (20.8 (3.2) mU/l). Post-exercise GH was less than 10 mU/l in 29 children (34% total; 49% group 1, 6% group 2, and 34% group 3). There was a positive relation between post-exercise GH and both bone age and public hair stage. Multiple regression analysis revealed that relevant predictors of a rise in GH with exercise were different for the sexes in these children with varying stature: for boys, bone age and pubic hair stage; for girls, height and height SDS. All the tall girls were in puberty. No statistical relation was observed between post-experience GH and cardiovascular response to exercise, time of day of exercise, time of eating before exercise, and plasma insulin or insulin to glucose ratio at time of exercise. We conclude that the GH response to the physiological stimulus of exercise is higher in puberty compared with childhood. Therefore, although children may be suspected of having GH deficiency after a failure of GH to increase after exercise, a non-response may be a normal finding in prepubertal children, independent of stature.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bierich J. R., Brügmann G., Schippert R. Die Spontansekretion des Wachstumshormons im nächtlichen Tiefschlaf. I. Messung, Berechnung und Normalwerte im Kindesalter. Monatsschr Kinderheilkd. 1985 Jun;133(6):342–346. [PubMed] [Google Scholar]
  2. Bierich J. R., Potthoff K. Die Spontansekretion des Wachstumshormons bei der konstitutionellen Entwicklungsverzögerung und der frühnormalen Pubertät. Monatsschr Kinderheilkd. 1979 Sep;127(9):561–565. [PubMed] [Google Scholar]
  3. Buckler J. M. Exercise as a screening test for growth hormone release. Acta Endocrinol (Copenh) 1972 Feb;69(2):219–229. doi: 10.1530/acta.0.0690219. [DOI] [PubMed] [Google Scholar]
  4. Evain-Brion D., Garnier P., Schimpff R. M., Chaussain J. L., Job J. C. Growth hormone response to thyrotropin-releasing hormone and oral glucose-loading tests in tall children and adolescents. J Clin Endocrinol Metab. 1983 Mar;56(3):429–432. doi: 10.1210/jcem-56-3-429. [DOI] [PubMed] [Google Scholar]
  5. Finkelstein J. W., Roffwarg H. P., Boyar R. M., Kream J., Hellman L. Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. J Clin Endocrinol Metab. 1972 Nov;35(5):665–670. doi: 10.1210/jcem-35-5-665. [DOI] [PubMed] [Google Scholar]
  6. Hartley L. H., Mason J. W., Hogan R. P., Jones L. G., Kotchen T. A., Mougey E. H., Wherry F. E., Pennington L. L., Ricketts P. T. Multiple hormonal responses to graded exercise in relation to physical training. J Appl Physiol. 1972 Nov;33(5):602–606. doi: 10.1152/jappl.1972.33.5.602. [DOI] [PubMed] [Google Scholar]
  7. Johanson A. J., Morris G. L. A single growth hormone determination to rule out growth hormone deficiency. Pediatrics. 1977 Mar;59(3):467–468. [PubMed] [Google Scholar]
  8. Johnsonbaugh R. E., Bybee D. E., Georges L. P. Exercise tolerance test. Single-sample screening technique to rule out growth-hormone deficiency. JAMA. 1978 Aug 18;240(7):664–666. doi: 10.1001/jama.240.7.664. [DOI] [PubMed] [Google Scholar]
  9. Keenan B. S., Killmer L. B., Jr, Sode J. Growth hormone response to exercise. A test of pituitary function in children. Pediatrics. 1972 Nov;50(5):760–764. [PubMed] [Google Scholar]
  10. Lippe B., Wong S. L., Kaplan S. A. Simultaneous assessment of growth hormone and ACTH reserve in children pretreated with diethylstilbestrol. J Clin Endocrinol Metab. 1971 Dec;33(6):949–956. doi: 10.1210/jcem-33-6-949. [DOI] [PubMed] [Google Scholar]
  11. Milner R. D., Burns E. C. Investigation of suspected growth hormone deficiency. On behalf of the Health Services Human Growth Hormone Committee. Arch Dis Child. 1982 Dec;57(12):944–947. doi: 10.1136/adc.57.12.944. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Nicoll A. G., Smail P. J., Forsyth C. C. Exercise test for growth hormone deficiency. Arch Dis Child. 1984 Dec;59(12):1177–1178. doi: 10.1136/adc.59.12.1177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Okada Y., Hikata T., Ishitobi K., Wada M., Santo Y., Harada Y. Human growth hormone secretion after exercise and oral glucose administration in patients with short stature. J Clin Endocrinol Metab. 1972 Jun;34(6):1055–1058. doi: 10.1210/jcem-34-6-1055. [DOI] [PubMed] [Google Scholar]
  14. Ong L., Reiser P., Coromilas J., Scherr L., Morrison J. Left ventricular function and rapid release of creatine kinase MB in acute myocardial infarction. Evidence for spontaneous reperfusion. N Engl J Med. 1983 Jul 7;309(1):1–6. doi: 10.1056/NEJM198307073090101. [DOI] [PubMed] [Google Scholar]
  15. Sperling M. A., Kenny F. M., Drash A. L. Arginine-induced growth hormone responses in children: effect of age and puberty. J Pediatr. 1970 Sep;77(3):462–465. doi: 10.1016/s0022-3476(70)80018-x. [DOI] [PubMed] [Google Scholar]
  16. Sutton J., Lazarus L. Growth hormone in exercise: comparison of physiological and pharmacological stimuli. J Appl Physiol. 1976 Oct;41(4):523–527. doi: 10.1152/jappl.1976.41.4.523. [DOI] [PubMed] [Google Scholar]
  17. de San Lazaro C., Parkin J. M., Turner S. J. Treadmill exercise test in short children. Arch Dis Child. 1984 Dec;59(12):1179–1182. doi: 10.1136/adc.59.12.1179. [DOI] [PMC free article] [PubMed] [Google Scholar]

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