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. 1985 Feb;19(1):18–21. doi: 10.1007/BF00199306

Localization of anti-osteogenic sarcoma monoclonal antibody 791T/36 in a primary human osteogenic sarcoma and its subsequent xenograft in immunodeprived mice

Malcolm V Pimm 1,✉, Alan C Perkins 2, Nicholas C Armitage 3, Robert W Baldwin 1
PMCID: PMC11039251  PMID: 3856475

Abstract

A primary human osteogenic sarcoma was visualized in situ by external gamma-camera imaging following administration of 131I-labelled anti-osteogenic sarcoma monoclonal antibody 791T/36. A xenograft of the tumour established in immunodeprived mice also showed localization of 131I-791T/36 determined by both gamma-camera imaging and organ distribution studies. Radiolabelled normal immunoglobulin showed no tumour localization. Expression of the 791T/36-defined antigen on xenografted tissue was further confirmed by reaction of its in vitro-cultured cells with fluorescein-labelled 791T/36 antibody.

Keywords: Monoclonal Antibody, Cancer Research, Sarcoma, Osteogenic Sarcoma, Tumour Localization

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