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. 2018 Jun 6;3(1):95–115. doi: 10.1016/S0733-8619(18)31058-2

Reye Syndrome

Darryl C De Vivo *,**
PMCID: PMC7135463  PMID: 3887130

Abstract

Reye syndrome has emerged as the quintessential example of an acute metabolic encephalopathy with an annual incidence ranging from 0.3 to 6.0 cases per 100,000 children. The general management has become standardized, and the mortality has declined to approximately 10 per cent. The role of aspirin in the etiopathogenesis remains controversial.

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