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. 1985 Apr;94(2):151–161. doi: 10.1017/s0022172400061350

The severity of whooping cough in hospitalised children--is it declining?

I D Johnston, H R Anderson, H P Lambert
PMCID: PMC2129417  PMID: 3989282

Abstract

Four hundred and sixty admissions for whooping cough to three hospitals between 1974-9 were reviewed. Many children had a long illness. More than half of them had severe or moderately severe coughing spasms and a quarter had pronounced feeding difficulties. The incidence of clinical pneumonia and convulsions was low and there were no deaths. The disease continues to be much more severe in infancy. There was some evidence that the disease declined in severity over the period studied. A number of factors including increased use of erythromycin may have contributed to this change.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baraff L. J., Wilkins J., Wehrle P. F. The role of antibiotics, immunizations, and adenoviruses in pertussis. Pediatrics. 1978 Feb;61(2):224–230. [PubMed] [Google Scholar]
  2. Barrie H. Treatment of whooping cough. Lancet. 1982 Oct 9;2(8302):830–831. doi: 10.1016/s0140-6736(82)92728-3. [DOI] [PubMed] [Google Scholar]
  3. Bass J. W., Klenk E. L., Kotheimer J. B., Linnemann C. C., Smith M. H. Antimicrobial treatment of pertussis. J Pediatr. 1969 Nov;75(5):768–781. doi: 10.1016/s0022-3476(69)80299-4. [DOI] [PubMed] [Google Scholar]
  4. Bassili W. R., Stewart G. T. Epidemiological evaluation of immunisation and other factors in the control of whooping-cough. Lancet. 1976 Feb 28;1(7957):471–474. doi: 10.1016/s0140-6736(76)91488-4. [DOI] [PubMed] [Google Scholar]
  5. Bennett N. M. Whooping cough in Melbourne. Med J Aust. 1973 Sep 8;2(10):481–487. doi: 10.5694/j.1326-5377.1973.tb128871.x. [DOI] [PubMed] [Google Scholar]
  6. COURT D., JACKSON H., KNOX G. The recognition of whooping-cough. Lancet. 1953 Nov 21;265(6795):1057–1060. doi: 10.1016/s0140-6736(53)90666-7. [DOI] [PubMed] [Google Scholar]
  7. Church M. A. Evidence of whooping-cough-vaccine efficacy from the 1978 whooping-cough epidemic in Hertfordshire. Lancet. 1979 Jul 28;2(8135):188–190. doi: 10.1016/s0140-6736(79)91447-8. [DOI] [PubMed] [Google Scholar]
  8. Demina A. A., Devyatkina N. P., Voloshina L. Z., Larina L. I., Semina N. A., Venglinskaya E. A., Kostyukova K. P. Serological types of whooping cough bacteria and their connection with immunity in vaccinated children. J Hyg Epidemiol Microbiol Immunol. 1973 Mar;17(3):304–315. [PubMed] [Google Scholar]
  9. Emerson H. Essential Problems in Pertussis. Am J Public Health Nations Health. 1939 Apr;29(4):337–340. doi: 10.2105/ajph.29.4.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Grob P. R., Crowder M. J., Robbins J. F. Effect of vaccination on severity and dissemination of whooping cough. Br Med J (Clin Res Ed) 1981 Jun 13;282(6280):1925–1928. doi: 10.1136/bmj.282.6280.1925. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Harris F., Bush G., Lewis M. Death of infants after triple vaccine. Lancet. 1979 Sep 1;2(8140):473–473. [PubMed] [Google Scholar]
  12. Islur J., Anglin C. S., Middleton P. J. The whooping cough syndrome: A continuing pediatric problem. Clin Pediatr (Phila) 1975 Feb;14(2):171–176. doi: 10.1177/000992287501400208. [DOI] [PubMed] [Google Scholar]
  13. JERNELIUS H. Pertussis complications and mortality during the period 1934 to 1953. Acta Paediatr. 1958 Jan;47(1):56–64. doi: 10.1111/j.1651-2227.1958.tb07858.x. [DOI] [PubMed] [Google Scholar]
  14. Jenkinson D. Whooping cough: what proportion of cases is notified in an epidemic? Br Med J (Clin Res Ed) 1983 Jul 16;287(6386):185–186. doi: 10.1136/bmj.287.6386.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. McKendrick M. W., Gully P. R., Geddes A. M. Protection against pertussis by immunisation. Br Med J. 1980 Nov 22;281(6252):1390–1391. doi: 10.1136/bmj.281.6252.1390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Melchior J. C., Jessen O. Hospitalsindtryk af kighosteepidemien 1973 - 1974. Ugeskr Laeger. 1976 May 31;138(23):1389–1391. [PubMed] [Google Scholar]
  17. Miller C. L., Fletcher W. B. Severity of notified whooping cough. Br Med J. 1976 Jan 17;1(6002):117–119. doi: 10.1136/bmj.1.6002.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Miller D. L., Alderslade R., Ross E. M. Whooping cough and whooping cough vaccine: the risks and benefits debate. Epidemiol Rev. 1982;4:1–24. doi: 10.1093/oxfordjournals.epirev.a036242. [DOI] [PubMed] [Google Scholar]
  19. Miller D. L., Ross E. M., Alderslade R., Bellman M. H., Rawson N. S. Pertussis immunisation and serious acute neurological illness in children. Br Med J (Clin Res Ed) 1981 May 16;282(6276):1595–1599. doi: 10.1136/bmj.282.6276.1595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Miller E., Jacombs B., Pollock T. M. Whooping-cough notifications. Lancet. 1980 Mar 29;1(8170):718–718. [PubMed] [Google Scholar]
  21. Mortimer E. A., Jr, Jones P. K. An evaluation of pertussis vaccine. Rev Infect Dis. 1979 Nov-Dec;1(6):927–934. doi: 10.1093/clinids/1.6.927. [DOI] [PubMed] [Google Scholar]
  22. Olson L. C. Pertussis. Medicine (Baltimore) 1975 Nov;54(6):427–469. doi: 10.1097/00005792-197511000-00001. [DOI] [PubMed] [Google Scholar]
  23. PRESTON N. W. TYPE-SPECIFIC IMMUNITY AGAINST WHOOPING-COUGH. Br Med J. 1963 Sep 21;2(5359):724–726. doi: 10.1136/bmj.2.5359.724. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Pavesio D., Ponzone A. Salbutamol and pertussis. Lancet. 1977 Jan 15;1(8003):150–151. doi: 10.1016/s0140-6736(77)91752-4. [DOI] [PubMed] [Google Scholar]
  25. Peltola H., Michelsson K. Efficacy of salbutamol in treatment of infant pertussis demonstrated by sound spectrum analysis. Lancet. 1982 Feb 6;1(8267):310–312. doi: 10.1016/s0140-6736(82)91570-7. [DOI] [PubMed] [Google Scholar]
  26. Pollard R. Relation between vaccination and notification rates for whooping cough in England and Wales. Lancet. 1980 May 31;1(8179):1180–1182. doi: 10.1016/s0140-6736(80)91632-3. [DOI] [PubMed] [Google Scholar]
  27. Pollock T. M., Miller E., Lobb J. Severity of whooping cough in England before and after the decline in pertussis immunisation. Arch Dis Child. 1984 Feb;59(2):162–165. doi: 10.1136/adc.59.2.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Pollock T. M., Morris J. A 7-year survey of disorders attributed to vaccination in North West Thames region. Lancet. 1983 Apr 2;1(8327):753–757. doi: 10.1016/s0140-6736(83)92037-8. [DOI] [PubMed] [Google Scholar]
  29. Robinson D. A., Mandal B. K., Ironside A. G., Dunbar E. M. Whooping cough--a study of severity in hospital cases. Arch Dis Child. 1981 Sep;56(9):687–691. doi: 10.1136/adc.56.9.687. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Trollfors B. Clinical course of whooping cough in children younger than six months. Acta Paediatr Scand. 1979 May;68(3):323–328. doi: 10.1111/j.1651-2227.1979.tb05014.x. [DOI] [PubMed] [Google Scholar]
  31. Vesselinova-Jenkins C. K., Newcombe R. G., Gray O. P., Skone J. F., Howells C. H., Lennox M., Hine D. J., Jenkins P. M., Munro J. A. The effects of immunisation upon the natural history of pertussis. A family study in the Cardiff area. J Epidemiol Community Health. 1978 Sep;32(3):194–199. doi: 10.1136/jech.32.3.194. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Voorhoeve A. M., Muller A. S., Schulpen T. W., t' Mannetje W., van Rens M. Machakos project studies. Agents affecting health of mother and child in a rural area of Kenya. IV: The epidemiology of pertussis. Trop Geogr Med. 1978 Mar;30(1):125–139. [PubMed] [Google Scholar]
  33. Walker E., Pinkerton I. W., Love W. C., Chaudhuri A. K., Datta J. B. Whooping cough in Glasgow 1969-80. J Infect. 1981 Jun;3(2):150–158. doi: 10.1016/s0163-4453(81)91311-6. [DOI] [PubMed] [Google Scholar]
  34. Walsh J. A., Warren K. S. Selective primary health care: an interim strategy for disease control in developing countries. N Engl J Med. 1979 Nov 1;301(18):967–974. doi: 10.1056/NEJM197911013011804. [DOI] [PubMed] [Google Scholar]
  35. Wynne J., Hull D. Why are children admitted to hospital? Br Med J. 1977 Oct 29;2(6095):1140–1142. doi: 10.1136/bmj.2.6095.1140. [DOI] [PMC free article] [PubMed] [Google Scholar]

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