Author Correction: Bone marrow-derived mesenchymal stem cells (BMSCs) repair acute necrotized pancreatitis by secreting microRNA-9 to target the NF-κB1/p50 gene in rats

Correction to: Scientific Reports 10.1038/s41598-017-00629-3, published online 03 April 2017

This article contains errors. As a result of errors during figure assembly, a TNF-α image panel mistakenly displays a duplication of an IL-1β image panel in Figure 3E. In Figure 4E, partial overlaps are shown for an image from the CD68 condition that was mistakenly used for the TNF-α condition and an image for the MPO group that was mistakenly used for the CD68 condition.

Fig. 3.

pri-miR-9-BMSCs could inhibit the local inflammatory response. The expressions of pro-inflammatory cytokines(IL-1β, IL-6, TNF-α, and MPO), NF-κB proteins (p-P65, P50) and CD68 were significantly decreased by pir-miR-9-BMSCs. On the contrary, the expressions of superoxide dismutase (SOD₁ and SOD₂) and anti-inflammatory proteins (IκBα and IκBβ) were significantly increased by pir-miR-9-BMSCs, compared with SAP, SAP + PBS, BMSCs, or TuD-BMSCs groups by gPCR (A,B), Western-blot (C,D) and IHC (E,F). Data are shown as mean ± SD for at least 3 separate experiments. ^%%P < 0.01, compared with NC, ^#p < 0.05, ^##p < 0.01 and ^###p < 0.001, compared with NC, ⁺p < 0.05, ⁺⁺p < 0.01 and ⁺⁺⁺p < 0.001, compared with SAP, ^*p < 0.05 and ^**p < 0.01, compared with SAP + PBS, ^@p < 0.05 and ^@@p < 0.01, compared with BMSCs, ^$p < 0.05 and ^$$p < 0.01, compared with Empty-virus BMSCs, ^†p < 0.05, ^††p < 0.01 and ^†††p < 0.001, compared with TuD-BMSCs by using paired t test. gPCR, General PCR, IHC, immunohistochemistry.

Fig. 4.

miR-9 could antagonize the local inflammatory response. The expressions of IL-1β, IL-6, TNF-α, MPO, p-P65, P50, and CD68 were significantly decreased by miR-9a-5p agomir. Inversely, the expressions of SOD₁, SOD₂, IκBα, and IκBβ were significantly increased by miR-9a-5p agomir, compared with SAP + PBS or miR-9a-5p control group, by gPCR (A,B), Western-blot (C,D) and IHC (E,F). Data are shown as mean ± SD for at least 3 separate experiments. ^%P < 0.05, compared with NC, ^#p < 0.05 and ^###p < 0.001, compared with NC, ^*p < 0.05, ^**p < 0.01 and ^***p < 0.001, compared with SAP + PBS, ^&p < 0.05, ^&&p < 0.01, and ^&&&p < 0.001, compared with miR-9a-5p control by using paired t test. SOD, Superoxide Dismutase, gPCR, General PCR, IHC, immunohistochemistry.

The correct Figures 3 and 4 and accompanying legends appear below.