Skip to main content
NCBI home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1985 Dec;20(6):675–680. doi: 10.1111/j.1365-2125.1985.tb05127.x

Haemodynamic dose-response effects of intravenous nisoldipine in coronary artery disease.

B Silke, M A Frais, P Muller, S P Verma, G Reynolds, S H Taylor
PMCID: PMC1400833  PMID: 4091998

Abstract

The circulatory consequences of slow-calcium channel blockade with a new dihydropyridine nisoldipine were evaluated at rest and during exercise-induced angina in 16 patients with angiographically proven coronary artery disease. In 10 patients resting cardiac stroke output (thermodilution) and pulmonary artery occluded pressure were determined following four intravenous nisoldipine injections (cumulative dosage of 1, 2, 4 and 8 micrograms kg-1). The exercise effects of nisoldipine were evaluated by comparing the effects of the 8 micrograms kg-1 cumulative dosage with a control exercise period at the same workload. At rest nisoldipine reduced systemic vascular resistance and mean arterial pressure, and increased heart rate, cardiac and stroke volume indices. During 4 min supine-bicycle exercise nisoldipine reduced systemic mean arterial pressure and vascular resistance; this resulted in augmented cardiac and stroke volume indices at an unchanged pulmonary artery occluded pressure. In six additional patients rest and exercise ejection fractions were measured using a nonimaging nuclear probe. Nisoldipine (4 micrograms kg-1) resulted in a small trend to increase left ventricular rest and exercise ejection fraction. These data demonstrated improved rest and exercise cardiac performance following nisoldipine in patients with severe coronary artery disease.

Full text

PDF
675

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atterhög J. H., Ekelund L. G., Melin A. L. Effect of nifedipine on exercise tolerance in patients with angina pectoris. Eur J Clin Pharmacol. 1975 Feb 28;8(2):125–130. doi: 10.1007/BF00561561. [DOI] [PubMed] [Google Scholar]
  2. Bacharach S. L., Green M. V., Borer J. S., Ostrow H. G., Redwood D. R., Johnston G. S. ECG-gated scintillation probe measurement of left ventricular function. J Nucl Med. 1977 Dec;18(12):1176–1183. [PubMed] [Google Scholar]
  3. Kazda S., Garthoff B., Meyer H., Schlossmann K., Stoepel K., Towart R., Vater W., Wehinger E. Pharmacology of a new calcium antagonistic compound, isobutyl methyl 1,4-dihydro-2,6-dimethyl-4(2-nitrophenyl)-3,5-pyridinedicarboxylate (Nisoldipine, Bay k 5552). Arzneimittelforschung. 1980;30(12):2144–2162. [PubMed] [Google Scholar]
  4. Kieval J., Myerburg R. J. The hemodynamic effects of calcium channel blocking agents: a brief review. Angiology. 1982 Aug;33(8):516–521. doi: 10.1177/000331978203300803. [DOI] [PubMed] [Google Scholar]
  5. Moskowitz R. M., Piccini P. A., Nacarelli G. V., Zelis R. Nifedipine therapy for stable angina pectoris: preliminary results of effects on angina frequency and treadmill exercise response. Am J Cardiol. 1979 Oct 22;44(5):811–816. doi: 10.1016/0002-9149(79)90202-9. [DOI] [PubMed] [Google Scholar]
  6. Silke B., Verma S. P., Ahuja R. C., Nelson G. I., Hussain M., Taylor S. H. Haemodynamic dose-response effects of i.v. verapamil in coronary artery disease. Herz. 1984 Dec;9(6):353–361. [PubMed] [Google Scholar]
  7. Silke B., Verma S. P., Nelson G. I., Hussain M., Taylor S. H. Haemodynamic dose-response effects of i.v. nicardipine in coronary artery disease. Br J Clin Pharmacol. 1984 Nov;18(5):717–724. doi: 10.1111/j.1365-2125.1984.tb02534.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Singh B. N. Pharmacological basis for the therapeutic applications of slow-channel blocking drugs. Angiology. 1982 Aug;33(8):492–515. doi: 10.1177/000331978203300802. [DOI] [PubMed] [Google Scholar]
  9. Stone P. H., Antman E. M., Muller J. E., Braunwald E. Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications. Ann Intern Med. 1980 Dec;93(6):886–904. doi: 10.7326/0003-4819-93-6-886. [DOI] [PubMed] [Google Scholar]
  10. Strashun A., Horowitz S. F., Goldsmith S. J., Teichholz L. E., Dicker A., Miceli K., Gorlin R. Noninvasive detection of left ventricular dysfunction with a portable electrocardiographic gated scintillation probe device. Am J Cardiol. 1981 Mar;47(3):610–617. doi: 10.1016/0002-9149(81)90545-2. [DOI] [PubMed] [Google Scholar]
  11. Vogt A., Kreuzer H. Hemodynamic effects of nisoldipine in chronic congestive heart failure. Arzneimittelforschung. 1983;33(6):877–879. [PubMed] [Google Scholar]
  12. Wagner H. N., Wake R., Nickoloff E., Natarajan T. K. The nuclear stethoscope: a simple device for generation of left ventricular volume curves. Am J Cardiol. 1976 Nov 23;38(6):747–750. doi: 10.1016/0002-9149(76)90352-0. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES