Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1972 Apr;26(2):129–138. doi: 10.1038/bjc.1972.19

Histology in Breast Cancer Prognosis

H R Champion, I W J Wallace, R J Prescott
PMCID: PMC2008433  PMID: 4114100

Abstract

Histological sections of the primary tumour and of homolateral axillary lymph nodes from 500 women with operable invasive breast cancer have been examined. The tumours have been graded and the degree of round cell infiltration assessed. These features, together with clinical palpability and pathological involvement of axillary nodes, have been related to survival.

It was found that prognosis was worse in patients with a high grade tumour and in those with histological evidence of axillary node spread. Round cell infiltration of the primary tumour did not confer improved survival.

The clinical state of the axillary nodes was associated with prognosis in so far that palpable nodes were twice as commonly the seat of metastatic spread as were impalpable nodes.

Full text

PDF
129

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLACK M. M., KERPE S., SPEER F. D. Lymph node structure in patients with cancer of the breast. Am J Pathol. 1953 May-Jun;29(3):505–521. [PMC free article] [PubMed] [Google Scholar]
  2. BLACK M. M., OPLER S. R., SPEER F. D. Survival in breast cancer cases in relation to the structure of the primary tumor and regional lymph nodes. Surg Gynecol Obstet. 1955 May;100(5):543–551. [PubMed] [Google Scholar]
  3. BLOOM H. J., RICHARDSON W. W. Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer. 1957 Sep;11(3):359–377. doi: 10.1038/bjc.1957.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bloom H. J., Richardson W. W., Field J. R. Host resistance and survival in carcinoma of breast: a study of 104 cases of medullary carcinoma in a series of 1,411 cases of breast cancer followed for 20 years. Br Med J. 1970 Jul 25;3(5716):181–188. doi: 10.1136/bmj.3.5716.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Champion H. R., Wallace I. W. Breast cancer grading. Br J Cancer. 1971 Sep;25(3):441–448. doi: 10.1038/bjc.1971.56. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cutler S. J., Black M. M., Mork T., Harvei S., Freeman C. Further observations on prognostic factors in cancer of the female breast. Cancer. 1969 Oct;24(4):653–667. doi: 10.1002/1097-0142(196910)24:4<653::aid-cncr2820240402>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  7. Hamilton T., Fraser J., Bruce J. Carcinoma of the breast--a clinical trial. Br J Surg. 1969 Aug;56(8):615–615. [PubMed] [Google Scholar]
  8. Hamlin I. M. Possible host resistance in carcinoma of the breast: a histological study. Br J Cancer. 1968 Sep;22(3):383–401. doi: 10.1038/bjc.1968.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Maccarty W. C. LONGEVITY IN CANCER: A STUDY OF 293 CASES. Ann Surg. 1922 Jul;76(1):9–12. [PMC free article] [PubMed] [Google Scholar]
  10. RICHARDSON W. W. Medullary carcinoma of the breast; a distinctive tumour type with a relatively good prognosis following radical mastectomy. Br J Cancer. 1956 Sep;10(3):415–423. doi: 10.1038/bjc.1956.48. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Tough I. C., Carter D. C., Fraser J., Bruce J. Histological grading in breast cancer. Br J Cancer. 1969 Jun;23(2):294–301. doi: 10.1038/bjc.1969.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Treatment of early mammary carcinoma: a cooperative international study. Ann Surg. 1969 Dec;170(6):875–878. doi: 10.1097/00000658-196912000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES