Abstract
The nuclear material from human lymphocytes stimulated with phytohaemagglutinin (PHA) will produce a marked increase of DNA synthesis in unstimulated isologous lymphocytes which is far in excess of the normal response to PHA by the same lymphocytes. It is postulated that release of nuclear complexes from a few lymphocytes transformed in response to a specific stimulus is responsible for the transformation produced in surrounding lymphocytes which are non-responsive to the initial antigenic challenge.
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Selected References
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