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. 1977 Dec;21:65–69. doi: 10.1289/ehp.772165

Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.

A J Garro, R A Phillips
PMCID: PMC1475352  PMID: 417917

Abstract

The presumed halothane metabolite, 2-bromo-1,1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtils transformation assay to score the production of mutagenic lesions in transforming DNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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