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. 1974 Aug;17(4):561–569.

B-cell markers on lymphoblasts in acute lymphoblastic leukaemia

K J Gajl-Peczalska, C D Bloomfield, M E Nesbit, J H Kersey
PMCID: PMC1554089  PMID: 4219600

Abstract

Acute lymphoblastic leukaemia (ALL) has been shown to be of T-cell or undefined origin. We now describe a man of 75 years with ALL of apparent B-cell origin. Thirty-five cases of untreated ALL were studied for B-cell and twenty-four of them also for T-cell markers. In the patient with ALL of B-cell type the lymphoblasts carried mu-lambda suggesting a monoclonal origin of the malignant cells. The remaining thirty-four cases exhibited relatively normal proportions and numbers of B-lymphocyte subpopulations. Four of the twenty-four cases studied for T cells had ALL of T-cell origin. In the remaining twenty patients T lymphocytes were present, but generally in decreased numbers. The one patient with ALL of B-cell type was an elderly man, while the other thirty-four cases of T-cell or undefined origin occurred in children or younger adults. This suggests that in older patients ALL, like other lymphoid malignancies, may more often be of B-cell origin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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