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. 1974 Sep;27(9):734–737. doi: 10.1136/jcp.27.9.734

The nitroblue tetrazolium (NBT) test in renal transplantation

A M Gordon 1,2, J D Briggs 1,2, P R F Bell 1,2
PMCID: PMC475456  PMID: 4610010

Abstract

The nitroblue tetrazolium (NBT) test has been evaluated as a means of differentiating episodes of infection and rejection in 10 cadaver kidney transplant recipients. Normal NBT values were observed during all 11 episodes of acute rejection. A significant elevation of the NBT score was encountered in six of eight episodes of infection after transplantation. A positive NBT result is useful additional evidence in favour of infection in patients in whom the differentiation of infection and rejection is proving difficult.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bell P. R., Briggs J. D., Kyle K., Dick H., Calman K. C., Quin R. O., Wood R. F., Paton A. M., Macpherson S. G., Deane R. F. Renal transplantation: an analysis of 33 cases. Br Med J. 1972 Nov 18;4(5837):408–413. doi: 10.1136/bmj.4.5837.408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Briggs J. D., Timbury M. C., Paton A. M., Bell P. R. Viral infection and renal transplant rejection. Br Med J. 1972 Dec 2;4(5839):520–522. doi: 10.1136/bmj.4.5839.520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Freeman R., King B. Infective complications of indwelling intravenous catheters and the monitoring of infections by the nitroblue-tetrazolium test. Lancet. 1972 May 6;1(7758):992–993. doi: 10.1016/s0140-6736(72)91158-0. [DOI] [PubMed] [Google Scholar]
  4. Gordon A. M., Rowan R. M., Brown T., Carson H. G. Routine application of the nitroblue tetrazolium test in the clinical laboratory. J Clin Pathol. 1973 Jan;26(1):52–56. doi: 10.1136/jcp.26.1.52. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Matula G., Paterson P. Y. N.B.T. tests in a patient on steroids. Lancet. 1971 Apr 17;1(7703):803–804. doi: 10.1016/s0140-6736(71)91247-5. [DOI] [PubMed] [Google Scholar]
  6. Miller D. R., Kaplan H. G. Decreased nitroblue tetrazolium dye reduction in the phagocytes of patients receiving prednisone. Pediatrics. 1970 May;45(5):861–865. [PubMed] [Google Scholar]
  7. Naish P., Peters D. K., Shackman R. Increased urinary fibrinogen derivatives after renal allotransplantation. Lancet. 1973 Jun 9;1(7815):1280–1282. doi: 10.1016/s0140-6736(73)91295-6. [DOI] [PubMed] [Google Scholar]
  8. Park B. H., Fikrig S. M., Smithwick E. M. Infection and nitroblue-tetrazolium reduction by neutrophils. A diagnostic acid. Lancet. 1968 Sep 7;2(7567):532–534. doi: 10.1016/s0140-6736(68)92406-9. [DOI] [PubMed] [Google Scholar]
  9. Rubinstein A., Pelet B. False-negative N.B.T. tests due to transient malfunction of neutrophils. Lancet. 1973 Feb 17;1(7799):382–382. doi: 10.1016/s0140-6736(73)90185-2. [DOI] [PubMed] [Google Scholar]
  10. Segal A. W., Trustey S. F., Levi A. J. Re-evaluation of nitroblue-tetrazolium test. Lancet. 1973 Oct 20;2(7834):879–883. doi: 10.1016/s0140-6736(73)92007-2. [DOI] [PubMed] [Google Scholar]
  11. Steigbigel R. T., Johnson P. K., Remington J. S. The nitroblue tetrazolium reduction test versus conventional hematology in the diagnosis of bacterial infection. N Engl J Med. 1974 Jan 31;290(5):235–238. doi: 10.1056/NEJM197401312900501. [DOI] [PubMed] [Google Scholar]
  12. Wellwood J. M., Ellis B. G., Hall J. H., Robinson D. R., Thompson A. E. Early warning of rejection? Br Med J. 1973 May 5;2(5861):261–265. doi: 10.1136/bmj.2.5861.261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Winchester J. F., Rowan R. M., Gordon A. M., Lindsay R. M., Black D. A. Interpretation of the nitroblue-tetrazolium test in regularly dialysed patients. Lancet. 1973 Aug 11;2(7824):292–293. doi: 10.1016/s0140-6736(73)90795-2. [DOI] [PubMed] [Google Scholar]
  14. Wollman M. R., David D. S., Brennan B. L., Lewy J. E., Stenzel K. H., Rubin A. L., Miller D. R. The nitroblue-tetrazolium test. Usefulness in detecting bacterial infections in uraemic and immunosuppressed renal transplant patients. Lancet. 1972 Aug 12;2(7772):289–291. doi: 10.1016/s0140-6736(72)92902-9. [DOI] [PubMed] [Google Scholar]
  15. Wood R. F., Gray A. C., Briggs J. D., Bell P. R. The prediction of acute rejection in human renal transplantation using the leucocyte migration test. Transplantation. 1973 Jul;16(1):41–45. doi: 10.1097/00007890-197307000-00008. [DOI] [PubMed] [Google Scholar]
  16. Wood R. F., Gray A. C. Evaluation of rosette inhibition test in renal transplantation. Br Med J. 1973 Dec 15;4(5893):649–651. doi: 10.1136/bmj.4.5893.649. [DOI] [PMC free article] [PubMed] [Google Scholar]

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