Abstract
We have previously reported the results of a retrospective study of the relationship between oral contraceptives and deep vein thrombosis and pulmonary embolism occurring in the absence of an evident predisposing cause. The present paper describes a similar investigation of the relationship between oral contraceptives and thromboembolism following certain surgical procedures.
Of 30 patients with thromboembolism, 12 (40%) had been using oral contraceptives during the month preceding surgery, while only 9 of 60 matched controls (15%) had been doing so. From these data it is estimated that the risk of postoperative thromboembolism is increased threefold to fourfold by the use of contraceptive steroids.
It is recognized that few of the episodes of deep vein thrombosis and pulmonary embolism that occur postoperatively are detectable clinically, and that not all of these are recorded in discharge summaries or diagnostic indexes. Despite these considerations, we have been unable to detect any important bias in the data which could account for the observed association between oral contraceptives and the development of postoperative thromboembolism.
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Selected References
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- Flanc C., Kakkar V. V., Clarke M. B. The detection of venous thrombosis of the legs using 125-I-labelled fibrinogen. Br J Surg. 1968 Oct;55(10):742–747. doi: 10.1002/bjs.1800551007. [DOI] [PubMed] [Google Scholar]
- Inman W. H., Vessey M. P. Investigation of deaths from pulmonary, coronary, and cerebral thrombosis and embolism in women of child-bearing age. Br Med J. 1968 Apr 27;2(5599):193–199. doi: 10.1136/bmj.2.5599.193. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Inman W. H., Vessey M. P., Westerholm B., Engelund A. Thromboembolic disease and the steroidal content of oral contraceptives. A report to the Committee on Safety of Drugs. Br Med J. 1970 Apr 25;2(5703):203–209. doi: 10.1136/bmj.2.5703.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KEMSLEY W. F., BILLEWICZ W. Z., THOMSON A. M. A new weight-for-height standard based on British anthropometric data. Br J Prev Soc Med. 1962 Oct;16:189–195. doi: 10.1136/jech.16.4.189. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
- Sartwell P. E., Masi A. T., Arthes F. G., Greene G. R., Smith H. E. Thromboembolism and oral contraceptives: an epidemiologic case-control study. Am J Epidemiol. 1969 Nov;90(5):365–380. doi: 10.1093/oxfordjournals.aje.a121082. [DOI] [PubMed] [Google Scholar]
- Vessey M. P., Doll R. Investigation of relation between use of oral contraceptives and thromboembolic disease. Br Med J. 1968 Apr 27;2(5599):199–205. doi: 10.1136/bmj.2.5599.199. [DOI] [PMC free article] [PubMed] [Google Scholar]