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. 1976 May;83(2):299–318.

Effects of amyloid induction on plasma protein turnover, and its implication.

R Kisilevsky, M Axelrad, S Brunet, M Richards
PMCID: PMC2032320  PMID: 57723

Abstract

Using polyacrylamide gel electrophoresis and radioiodinated plasma proteins, data on the rate constant for synthesis and fractional degradation rates for albumin, alpha1-, alpha2-, beta-, and gamma-globulins were obtained during accelerated amyloid induction in a murine model. The results indicate that during amyloid induction there is an increased rate of synthesis of alpha2-, beta-, and gamma-globulins but only the alpha2-globulin degradation rate is accelerated. In this experimental system, should amyloid protein be a degradation product of a plasma fraction, the alpha2-globulin appears as the most likely precursor. The implications of our findings are discussed, and a new general mechanism of amyloid production is proposed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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