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. 1981 Nov;74(3):723–729. doi: 10.1111/j.1476-5381.1981.tb10484.x

Stimulation of rat cerebellar guanosine 3',5'-cyclic monophosphate (cyclic GMP) levels: effects of amino acid antagonists.

G A Foster, P J Roberts
PMCID: PMC2071763  PMID: 6117346

Abstract

1 The ability of glutamate, aspartate and related neuroexcitants to produce large calcium-dependent increases in the levels of guanosine 3',5'-cyclic monophosphate (cyclic GMP) in immature rat cerebellar slices has been demonstrated. 2 These effects were inhibited by selective antagonist compounds, indicating the presence of at least two types of excitatory amino acid receptor mediating the cyclic GMP response. 3 Protoveratrine also produced large increases in cyclic GMP, and this action was antagonized by L-glutamate diethylester suggesting that released endogenous glutamate, subsequently interacting with its postsynaptic receptors, is the predominant mechanism. 4 The kinetic characteristics of several of the inhibitor compounds were investigated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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