Abstract
Our present and previous findings may be summarized as follows: The phenotype of C57BL/6 (B6) cytotoxic cells for allogeneic target cells is Thy-1+, Ly-1- Ly-2/3+, MSLA+, and Ig-. the phenotype of B6 cytotoxic cells for syngeneic tumor cells is Thy-1+, Ly-1+, Ly-2/3+, MSLA+, and Ig-. The phenotype of B6 cytotoxic cells for syngeneic tumor cells is Thy-1+, Ly-1+, Ly-2/3+, MSLA+, AND Ig-. Thus, differences in Ly phenotype appear to be exhibited not only by cytotoxic T cells as opposed to helper T cells, but also within subcategories of cytotoxic T cells.
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Selected References
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- Cantor H., Boyse E. A. Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen. J Exp Med. 1975 Jun 1;141(6):1376–1389. doi: 10.1084/jem.141.6.1376. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kisielow P., Hirst J. A., Shiku H., Beverley P. C., Hoffman M. K., Boyse E. A., Oettgen H. F. Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse. Nature. 1975 Jan 17;253(5488):219–220. doi: 10.1038/253219a0. [DOI] [PubMed] [Google Scholar]
- Shiku H., Bean M. A., Old L. J., Oettgen H. F. Cytotoxic reactions of murine lymphoid cells studied with a tritiated proline microcytotoxicity test. J Natl Cancer Inst. 1975 Feb;54(2):415–425. [PubMed] [Google Scholar]
- Shiku H., Kisielow P., Bean M. A., Takahashi T., Boyse E. A., Oettgen H. F., Old L. J. Expression of T-cell differentiation antigens on effector cells in cell-mediated cytotoxicity in vitro. Evidence for functional heterogeneity related to the surface phenotype of T cells. J Exp Med. 1975 Jan 1;141(1):227–241. doi: 10.1084/jem.141.1.227. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shiku H., Takahashi T., Bean M. A., Hämmerling U., Oettgen H. F., Old L. J. Surface phenotype of nonadherent peritoneal cells effecting cell-mediated cytotoxicity in vitro for allogeneic and syngeneic murine sarcoma cells. Isr J Med Sci. 1976 Apr-May;12(4-5):425–434. [PubMed] [Google Scholar]
