Abstract
A sensitive radioimmunoassay that can detect brain damage in cases of head injury and stroke was applied to blood samples from 13 patients before and after they received multiple treatments with electroconvulsive therapy for psychiatric disorder. None of the patients showed a significant increase in serum myelin basic protein immunoreactivity. As increased serum myelin basic protein immunoreactivity may reflect myelin damage it is apparent that in these patients electroconvulsive therapy did not cause measureable breakdown of myelin.
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Selected References
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- Biber A., Englert D., Dommasch D., Hempel K. Myelin basic protein in cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases. J Neurol. 1981;225(4):231–236. doi: 10.1007/BF00313295. [DOI] [PubMed] [Google Scholar]
- Bolwig T. G., Hertz M. M., Paulson O. B., Spotoft H., Rafaelsen O. J. The permeability of the blood-brain barrier during electrically induced seizures in man. Eur J Clin Invest. 1977 Apr;7(2):87–93. doi: 10.1111/j.1365-2362.1977.tb01578.x. [DOI] [PubMed] [Google Scholar]
- Bolwig T. G., Hertz M. M., Westergaard E. Acute hypertension causing blood-brain barrier breakdown during epileptic seizures. Acta Neurol Scand. 1977 Oct;56(4):335–342. doi: 10.1111/j.1600-0404.1977.tb01440.x. [DOI] [PubMed] [Google Scholar]
- Kendell R. E. The present status of electroconvulsive therapy. Br J Psychiatry. 1981 Oct;139:265–283. doi: 10.1192/bjp.139.4.265. [DOI] [PubMed] [Google Scholar]
- Palfreyman J. W., Thomas D. G., Ratcliffe J. G. Radioimmunoassay of human myelin basic protein in tissue extract, cerebrospinal fluid and serum and its clinical application to patients with head injury. Clin Chim Acta. 1978 Jan 16;82(3):259–270. doi: 10.1016/0009-8981(78)90008-6. [DOI] [PubMed] [Google Scholar]