Abstract
A 53-year-old man, who had been exposed for 23 years to polyvinyl chloride (PVC) in the bagging area of a vinyl chloride polymerisation plant, presented with a diffuse micronodular infiltrate on his chest radiograph. Light microscopy of lung obtained by drill biopsy showed a diffuse infiltration with histiocytes and multinucleated giant cells, with some collagen formation. Ultrastructural studies showed foreign particles in the macrophages, which were identical with PVC powder viewed under the electron microscope. Incubation of PVC powder with human lung macrophages in vitro showed that the macrophages englufed the powder to give a similar ultrastructural appearance.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Frongia N., Spinazzola A., Bucarelli A. Lesioni polmonari sperimentali da inalazione prolungata di polveri di PVC in ambiente di lavoro. Med Lav. 1974 Sep-Oct;65(9-10):321–342. [PubMed] [Google Scholar]
- Lilis R., Anderson H., Miller A., Selikoff I. J. Pulmonary changes among vinyl chloride polymerization workers. Chest. 1976 Feb;69(2 Suppl):299–303. doi: 10.1378/chest.69.2.299. [DOI] [PubMed] [Google Scholar]
- Lilis R., Anderson H., Nicholson W. J., Daum S., Fischbein A. S., Selikoff I. J. Prevalence of disease among vinyl chloride and polyvinyl chloride workers. Ann N Y Acad Sci. 1975 Jan 31;246:22–41. doi: 10.1111/j.1749-6632.1975.tb51078.x. [DOI] [PubMed] [Google Scholar]
- Miller A., Teirstein A. S., Chuang M., Selikoff I. J., Warshaw R. Changes in pulmonary function in workers exposed to vinyl chloride and polyvinyl chloride. Ann N Y Acad Sci. 1975 Jan 31;246:42–52. doi: 10.1111/j.1749-6632.1975.tb51079.x. [DOI] [PubMed] [Google Scholar]
- Prodan L., Suciu I., Pîslaru V., Ilea E., Pascu L. Experimental chronic poisoning with vinyl chloride (monochloroethene). Ann N Y Acad Sci. 1975 Jan 31;246:159–163. doi: 10.1111/j.1749-6632.1975.tb51091.x. [DOI] [PubMed] [Google Scholar]
- Suciu I., Prodan L., Ilea E., Păduraru A., Pascu L. Clinical manifestations in vinyl chloride poisoning. Ann N Y Acad Sci. 1975 Jan 31;246:53–69. doi: 10.1111/j.1749-6632.1975.tb51080.x. [DOI] [PubMed] [Google Scholar]
- Szende B., Lapis K., Nemes A., Pinter A. Pneumoconiosis caused by the inhalation of polyvinylchloride dust. Med Lav. 1970 Aug-Sep;61(8):433–436. [PubMed] [Google Scholar]