Abstract
The catecholamine-storing cells in the paraganglia of old rats showed structural characteristics common to adrenomedullary and paraganglionic cells of young animals. No sign of degeneration was found. Lipofuscin pigment was observed in most cells. The paraganglia were innervated and well supplied by fenestrated sinusoidal capillaries. Their fine structure suggests active endocrine function. An increase in the total bulk of the paraganglia in old rats suggests that they have a physiological role in senescence.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- COUPLAND R. E. (ELECTRON MICROSCOPIC OBSERVATIONS ON THE STRUCTURE OF THE RAT ADRENAL MEDULLA. I. THE ULTRASTRUCTURE AND ORGANIZATION OF CHROMAFFIN CELLS IN THE NORMAL ADRENAL MEDULLA.) J Anat. 1965 Apr;99:231–254. [PMC free article] [PubMed] [Google Scholar]
- Coupland R. E. Electron microscopic observations on the structure of the rat adrenal medulla: II. Normal innervation. J Anat. 1965 Apr;99(Pt 2):255–272. [PMC free article] [PubMed] [Google Scholar]
- Coupland R. E., Hopwood D. The mechanism of the differential staining reaction for adrenaline-and noreadrenaline-storing granules in tissues fixed in glutaraldehyde. J Anat. 1966 Apr;100(Pt 2):227–243. [PMC free article] [PubMed] [Google Scholar]
- Coupland R. E., Weakley B. S. Electron microscopic observation on the adrenal medulla and extra-adrenal chromaffin tissue of the postnatal rabbit. J Anat. 1970 Mar;106(Pt 2):213–231. [PMC free article] [PubMed] [Google Scholar]
- ELFVIN L. G. THE FINE STRUCTURE OF THE CELL SURFACE OF CHROMAFFIN CELLS IN THE RAT ADRENAL MEDULLA. J Ultrastruct Res. 1965 Apr;12:263–286. doi: 10.1016/s0022-5320(65)80099-5. [DOI] [PubMed] [Google Scholar]
- Hervonen A. Development of catecholamine--storing cells in human fetal paraganglia and adrenal medulla. A histochemical and electron microscopical study. Acta Physiol Scand Suppl. 1971;368:1–94. [PubMed] [Google Scholar]
- Hervonen A., Partanen S., Vaalasti A., Partanen M., Kanerva L., Alho H. The distribution and endocrine nature of the abdominal paraganglia of adult man. Am J Anat. 1978 Dec;153(4):563–572. doi: 10.1002/aja.1001530407. [DOI] [PubMed] [Google Scholar]
- Hervonen A., Pickel V. M., Joh T. H., Reis D. J., Linnoila I., Kanerva L., Miller R. J. Immunocytochemical demonstration of the catecholamine-synthesizing enzymes and neuropeptides in the catecholamine-storing cells of human fetal sympathetic nervous system. Adv Biochem Psychopharmacol. 1980;25:373–378. [PubMed] [Google Scholar]
- Mascorro J. A., Yates R. D. Innervation of abdominal paraganglia: an ultrastructural study. J Morphol. 1974 Feb;142(2):153–163. doi: 10.1002/jmor.1051420204. [DOI] [PubMed] [Google Scholar]
- Mascorro J. A., Yates R. D. Paraneurons and paraganglia: histological and ultrastructural comparisons between intraganglionic paraneurons and extra-adrenal paraganglion cells. Adv Biochem Psychopharmacol. 1980;25:201–213. [PubMed] [Google Scholar]
- Mascorro J. A., Yates R. D. The anatomical distribution and morphology of extraadrenal chromaffin tissue (abdominal paraganglia) in the dog. Tissue Cell. 1977;9(3):447–460. doi: 10.1016/0040-8166(77)90005-2. [DOI] [PubMed] [Google Scholar]
- Mascorro J. A., Yates R. D. Ultrastructural studies of the effects of reserpine on mouse abdominal sympathetic paraganglia. Anat Rec. 1971 Jul;170(3):269–279. doi: 10.1002/ar.1091700303. [DOI] [PubMed] [Google Scholar]
- McDonald D. M., Blewett R. W. Location and size of carotid body-like organs (paraganglia) revealed in rats by the permeability of blood vessels to Evans blue dye. J Neurocytol. 1981 Aug;10(4):607–643. doi: 10.1007/BF01262593. [DOI] [PubMed] [Google Scholar]
- Partanen M., Chiueh C. C., Rapoport S. I. Age related increase in catecholamine-containing paraganglia in male Fischer-344 rats. Anat Rec. 1981 Nov;201(3):563–566. doi: 10.1002/ar.1092010312. [DOI] [PubMed] [Google Scholar]
- REYNOLDS E. S. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 1963 Apr;17:208–212. doi: 10.1083/jcb.17.1.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATSON M. L. Staining of tissue sections for electron microscopy with heavy metals. J Biophys Biochem Cytol. 1958 Jul 25;4(4):475–478. doi: 10.1083/jcb.4.4.475. [DOI] [PMC free article] [PubMed] [Google Scholar]