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. 1978 May;5(5):447–451. doi: 10.1111/j.1365-2125.1978.tb01653.x

A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.

W Esselinckx, P A Bacon, E F Ring, D Crooke, A J Collins, D Demottaz
PMCID: PMC1429353  PMID: 656284

Abstract

1 Three intra-articular prednisolone analogues have been studied in a group of forty-six rheumatoid arthritic subjects. Each compound was tested at 50 mg and 100 mg dose over 3 weeks. 2 The anti-inflammatory effect was assessed by quantitative thermography. Systemic escape of the drug was monitored by plasma prednisolone and cortisol levels. 3 Both the systemic escape from the joint and the duration of effect on injected and uninjected knees were related to drug solubility. 4 Depression of plasma cortisol occurred with all three preparations and was most prolonged with the long-acting preparation. 5 Increasing the dose from 50 mg to 100 mg increased the antiflammatory effect only with the soluble acetate preparation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BILKA P. J., GAULT N. L. Intra-articular steroid therapy. Comparative efficiency of 6-methylprednisolone acetate in cases of rheumatoid arthritis. Postgrad Med. 1959 Nov;26:726–728. doi: 10.1080/00325481.1959.11712696. [DOI] [PubMed] [Google Scholar]
  2. Bain L. S., Balch H. W., Jacomb R. G. Parenteral administration of 6-alpha-methylprednisolone-21- acetate. I. Intra-articular injection: comparison with hydrocortisone acetate. Ann Phys Med. 1967 May;9(2):43–48. [PubMed] [Google Scholar]
  3. Collins A. J., Cosh J. A. Temperature and biochemical studies of joint inflammation. A preliminary investigation. Ann Rheum Dis. 1970 Jul;29(4):386–392. doi: 10.1136/ard.29.4.386. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Collins A. J., Ring E. F., Cosh J. A., Bacon P. A. Quantitation of thermography in arthritis using multi-isothermal analysis. I. The thermographic index. Ann Rheum Dis. 1974 Mar;33(2):113–115. doi: 10.1136/ard.33.2.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HOLLANDER J. L., BROWN E. M., Jr, JESSAR R. A., BROWN C. Y. Hydrocortisone and cortisone injected into arthritic joints; comparative effects of and use of hydrocortisone as a local antiarthritic agent. J Am Med Assoc. 1951 Dec 22;147(17):1629–1635. doi: 10.1001/jama.1951.03670340019005. [DOI] [PubMed] [Google Scholar]
  6. MURDOCH W. R., WILL G. Methylprednisolone acetate in intra-articular therapy. Clinical, biochemical, and chromatographic studies. Br Med J. 1962 Mar 3;1(5278):604–606. doi: 10.1136/bmj.1.5278.604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Murphy B. E. Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. J Clin Endocrinol Metab. 1967 Jul;27(7):973–990. doi: 10.1210/jcem-27-7-973. [DOI] [PubMed] [Google Scholar]
  8. PHILIPS V. K., ROTHERMICH N. O. Local injection of prednisolone TBA in the treatment of rheumatic diseases. Ohio State Med J. 1957 Jan;53(1):45–46. [PubMed] [Google Scholar]
  9. Turner A. K., Carroll C. J., Pinkus J. L., Charles D., Chattoraj S. C. Simultaneous competitive protein binding assay for cortissol, cortisone, and prednisolone in plasma, and its clinical application. Clin Chem. 1973 Jul;19(7):731–736. [PubMed] [Google Scholar]

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