Abstract
Paired gonococcal isolates from 38 patients with recurrent episodes of gonorrhoea at varying intervals were examined for similarity by means of gonococcal auxotyping and susceptibility to antibiotics. A different gonococcal strain was the cause of the second infection in 53% of the patients. Longer intervals between infections were significantly associated with greater numbers of dissimilar strains as a cause of the second infection. The same strain was usually found in infections occurring within 60 days of each other whereas different strains were more likely to cause infections occurring more than 60 days apart. The isolates causing the second infection were significantly more susceptible to penicillin.
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Selected References
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- Bisno A. L., Ofek I., Beachey E. H., Curran J. W. Human immunity to gonococci: studies of opsonization by sera of prostitutes and nuns. Trans Assoc Am Physicians. 1974;87:195–204. [PubMed] [Google Scholar]
- Brooks G. F., Darrow W. W., Day J. A. Repeated gonorrhea: an analysis of importance and risk factors. J Infect Dis. 1978 Feb;137(2):161–169. doi: 10.1093/infdis/137.2.161. [DOI] [PubMed] [Google Scholar]
- Brooks G. F., Ingwer I. Studies on the relationships between serum bactericidal activity and uncomplicated genital infections due to Neisseria gonorrhoeae. J Infect Dis. 1978 Sep;138(3):333–339. doi: 10.1093/infdis/138.3.333. [DOI] [PubMed] [Google Scholar]
- Catlin B. W. Nutritional profiles of Neisseria gonorrhoeae, Neisseria meningitidis, and Neisseria lactamica in chemically defined media and the use of growth requirements for gonococcal typing. J Infect Dis. 1973 Aug;128(2):178–194. doi: 10.1093/infdis/128.2.178. [DOI] [PubMed] [Google Scholar]
- Catlin B. W., Pace P. J. Auxotypes and penicillin susceptibilities of Neisseria gonorrhoeae isolated from patients with gonorrhea involving two or more sites. Antimicrob Agents Chemother. 1977 Aug;12(2):147–156. doi: 10.1128/aac.12.2.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Catlin B. W., Pace P. J. Nutritional requirements and penicillin susceptibilities of gonococci from pharyngeal and anogenital sites. Br J Vener Dis. 1977 Oct;53(5):299–303. doi: 10.1136/sti.53.5.299. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eisenstein B. I., Lee T. J., Sparling P. F. Penicillin sensitivity and serum resistance are independent attributes of strains of Neisseria gonorrhoeae causing disseminated gonococcal infection. Infect Immun. 1977 Mar;15(3):834–841. doi: 10.1128/iai.15.3.834-841.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kasper D. L., Rice P. A., McCormick W. M. Bactericidal antibody in genital infection due to Neisseria gonorrhoeae. J Infect Dis. 1977 Feb;135(2):243–251. doi: 10.1093/infdis/135.2.243. [DOI] [PubMed] [Google Scholar]
- Kaufman R. E., Johnson R. E., Jaffe H. W., Thornsberry C., Reynolds G. H., Wiesner P. J. National gonorrhea therapy monitoring study: treatment results. N Engl J Med. 1976 Jan 1;294(1):1–4. doi: 10.1056/NEJM197601012940101. [DOI] [PubMed] [Google Scholar]
- Kearns D. H., Seibert G. B., O'Reilly R., Lee L., Logan L. Paradox of the immune response to uncomplicated gonococcal urethritis. N Engl J Med. 1973 Nov 29;289(22):1170–1174. doi: 10.1056/NEJM197311292892205. [DOI] [PubMed] [Google Scholar]
- Martin J. E., Jr, Lester A. Transgrow, a medium for transport and growth of Neisseria gonorrhoeae and Neisseria meningitidis. HSMHA Health Rep. 1971 Jan;86(1):30–33. [PMC free article] [PubMed] [Google Scholar]
- Noble R. C. Characterisation of Neisseria gonorrhoeae from women with simultaneous infections at two sites. Br J Vener Dis. 1980 Feb;56(1):3–5. doi: 10.1136/sti.56.1.3. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Noble R. C., Kirk N. M., Slagel W. A., Vance B. J., Somes G. W. Recidivism among patients with gonococcal infection presenting to a venereal disease clinic. Sex Transm Dis. 1977 Apr-Jun;4(2):39–43. doi: 10.1097/00007435-197704000-00001. [DOI] [PubMed] [Google Scholar]
- Noble R. C., Schell S. C. Acrylamide gel electrophoresis of proteins of Neisseria gonorrhoeae as an epidemiological tool. Infect Immun. 1978 Jan;19(1):178–186. doi: 10.1128/iai.19.1.178-186.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Olsen G. A. Consumption of antibiotics in Greenland, 1964-70. IV. Changes in the sensitivity of N. gonorrhoeae to antibiotics. Br J Vener Dis. 1973 Feb;49(1):33–41. doi: 10.1136/sti.49.1.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
- REYN A., BENTZON M. W. SENSITIVITY TO ANTIBIOTICS OF GONOCOCCAL STRAINS ISOLATED BY REPEATED CULTURING FROM THE SAME PATIENT. Acta Derm Venereol. 1963;43:394–398. [PubMed] [Google Scholar]
- Short H. B., Ploscowe V. B., Weiss J. A., Young F. E. Rapid method for auxotyping multiple strains of Neisseria gonorrhoeae. J Clin Microbiol. 1977 Sep;6(3):244–248. doi: 10.1128/jcm.6.3.244-248.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Silver P. S., Darling W. M. Penicillin-insensitive gonococci in the Bolton area. Preponderance in young women and immigrants. Br J Vener Dis. 1971 Oct;47(5):367–372. doi: 10.1136/sti.47.5.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stolz E., Zwart H. G., Michel M. F. Activity of eight antimicrobial agents in vitro against N. Gonorrhoeae. Br J Vener Dis. 1975 Aug;51(4):257–264. doi: 10.1136/sti.51.4.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tramont E. C., Griffiss J. M., Rose D., Brooks G. F., Artenstein M. S. Clinical correlation of strain differentiation of Neisseria gonorrhoeae. J Infect Dis. 1976 Aug;134(2):128–134. doi: 10.1093/infdis/134.2.128. [DOI] [PubMed] [Google Scholar]