Abstract
The growth of 95 children with malignant disease was studied over a 3- or 4-year period, and compared with the growth of normal children matched for age and sex by calculation of the standard deviation score. The mean standard deviation score of the children with leukaemia fell in the first year of treatment, and thereafter showed little change, remaining below the normal. This effect was related to cranial and craniospinal irradiation, but not to age or duration of chemotherapy. The loss in eventual height attained was small and does not suggest any long-term interference with growth hormone production.
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Selected References
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- Dacou-Voutetakis C., Haidas S., Zannos-Mariolea L. Letter: Radiation and pituitary function in children. Lancet. 1975 Dec 13;2(7946):1206–1207. doi: 10.1016/s0140-6736(75)92692-6. [DOI] [PubMed] [Google Scholar]
- Probert J. C., Parker B. R., Kaplan H. S. Growth retardation in children after megavoltage irradiation of the spine. Cancer. 1973 Sep;32(3):634–639. doi: 10.1002/1097-0142(197309)32:3<634::aid-cncr2820320316>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
- Shalet S. M., Beardwell C. G., Jones P. H., Pearson D. Growth hormone deficiency after treatment of acute leukaemia in children. Arch Dis Child. 1976 Jul;51(7):489–493. doi: 10.1136/adc.51.7.489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shalet S. M., Beardwell C. G., MacFarlane I. A., Jones P. H., Pearson D. Endocrine morbidity in adults treated with cerebral irradiation for brain tumours during childhood. Acta Endocrinol (Copenh) 1977 Apr;84(4):673–680. doi: 10.1530/acta.0.0840673. [DOI] [PubMed] [Google Scholar]
- Shalet S. M., Beardwell C. G., Morris-Jones P. H., Pearson D. Pituitary function after treatment of intracranial tumours in children. Lancet. 1975 Jul 19;2(7925):104–107. doi: 10.1016/s0140-6736(75)90006-9. [DOI] [PubMed] [Google Scholar]
- Shalet S. M., Beardwell C. G., Pearson D., Jones P. H. The effect of varying doses of cerebral irradiation on growth hormone production in childhood. Clin Endocrinol (Oxf) 1976 May;5(3):287–290. doi: 10.1111/j.1365-2265.1976.tb01955.x. [DOI] [PubMed] [Google Scholar]
- Tanner J. M., Lejarraga H., Cameron N. The natural history of the Silver-Russell syndrome: a longitudinal study of thirty-nine cases. Pediatr Res. 1975 Aug;9(8):611–623. doi: 10.1203/00006450-197508000-00001. [DOI] [PubMed] [Google Scholar]
- Tanner J. M., Whitehouse R. H., Takaishi M. Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. II. Arch Dis Child. 1966 Dec;41(220):613–635. doi: 10.1136/adc.41.220.613. [DOI] [PMC free article] [PubMed] [Google Scholar]