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. 1981 Feb;102(2):262–270.

The role of calcium in the ischemic myocardium.

W G Nayler
PMCID: PMC1903686  PMID: 7008622

Abstract

Ischemia of the myocardium results in a loss of ultrastructure and function. Tension generation is diminished or abolished, electrolyte imbalance occurs, and the ATP-generating capacity of the mitochondria is reduced. An intracellular accumulation of Ca2+ appears to precipitate many of these changes, the intracellular accumulation of Ca2+ being caused, in turn, by a failure of the ATP-dependent mechanisms responsible for maintaining intracellular homeostasis with respect to Ca2+. This hypothesis has been tested by the use of hypothermia, pretreatment with verapamil and a reduced extracellular Ca2+ to modify the events precipitated by an ischemic episode.

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Selected References

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  1. BRADLEY L. B., JACOB M., JACOBS E. E., SANADI D. R. Uncoupling of oxidative phosphorylation by cadmium ion. J Biol Chem. 1956 Nov;223(1):147–156. [PubMed] [Google Scholar]
  2. Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976 May 7;72:248–254. doi: 10.1016/0003-2697(76)90527-3. [DOI] [PubMed] [Google Scholar]
  3. Clark R. E., Ferguson T. B., West P. N., Shuchleib R. C., Henry P. D. Pharmacological preservation of the ischemic heart. Ann Thorac Surg. 1977 Oct;24(4):307–314. doi: 10.1016/s0003-4975(10)63405-4. [DOI] [PubMed] [Google Scholar]
  4. El-Sherif N., Lazzara R. Reentrant ventricular arrhythmias in the late myocardial infarction period. 7. Effect of verapamil and D-600 and the role of the "slow channel". Circulation. 1979 Sep;60(3):605–615. doi: 10.1161/01.cir.60.3.605. [DOI] [PubMed] [Google Scholar]
  5. Hearse D. J., Humphrey S. M., Nayler W. G., Slade A., Border D. Ultrastructural damage associated with reoxygenation of the anoxic myocardium. J Mol Cell Cardiol. 1975 May;7(5):315–324. doi: 10.1016/0022-2828(75)90121-2. [DOI] [PubMed] [Google Scholar]
  6. Hearse D. J. Oxygen deprivation and early myocardial contractile failure: a reassessment of the possible role of adenosine triphosphate. Am J Cardiol. 1979 Nov;44(6):1115–1121. doi: 10.1016/0002-9149(79)90177-2. [DOI] [PubMed] [Google Scholar]
  7. JENNINGS R. B., SOMMERS H. M., KALTENBACH J. P., WEST J. J. ELECTROLYTE ALTERATIONS IN ACUTE MYOCARDIAL ISCHEMIC INJURY. Circ Res. 1964 Mar;14:260–269. doi: 10.1161/01.res.14.3.260. [DOI] [PubMed] [Google Scholar]
  8. Jennings R. B., Ganote C. E., Reimer K. A. Ischemic tissue injury. Am J Pathol. 1975 Oct;81(1):179–198. [PMC free article] [PubMed] [Google Scholar]
  9. Jennings R. B., Hawkins H. K., Lowe J. E., Hill M. L., Klotman S., Reimer K. A. Relation between high energy phosphate and lethal injury in myocardial ischemia in the dog. Am J Pathol. 1978 Jul;92(1):187–214. [PMC free article] [PubMed] [Google Scholar]
  10. Kahles H., Göring G. G., Nordbeck H., Preusse C. J., Spieckermann P. G. Functional behaviour of isolated heart muscle mitochondria after in situ ischemia. Polarographic analysis of mitochondrial oxidative phosphorylation. Basic Res Cardiol. 1977 Nov-Dec;72(6):563–574. doi: 10.1007/BF01907037. [DOI] [PubMed] [Google Scholar]
  11. Katz A. M. Effects of ischemia on the contractile processes of heart muscle. Am J Cardiol. 1973 Sep 20;32(4):456–460. doi: 10.1016/s0002-9149(73)80036-0. [DOI] [PubMed] [Google Scholar]
  12. Katz A. M., Reuter H. Cellular calcium and cardiac cell death. Am J Cardiol. 1979 Jul;44(1):188–190. doi: 10.1016/0002-9149(79)90270-4. [DOI] [PubMed] [Google Scholar]
  13. Nayler W. G., Fassold E., Yepez C. Pharmacological protection of mitochondrial function in hypoxic heart muscle: Effect of verapamil, propranolol, and methylprednisolone. Cardiovasc Res. 1978 Mar;12(3):152–161. doi: 10.1093/cvr/12.3.152. [DOI] [PubMed] [Google Scholar]
  14. Nayler W. G., Ferrari R., Williams A. Protective effect of pretreatment with verapamil, nifedipine and propranolol on mitochondrial function in the ischemic and reperfused myocardium. Am J Cardiol. 1980 Aug;46(2):242–248. doi: 10.1016/0002-9149(80)90064-8. [DOI] [PubMed] [Google Scholar]
  15. Nayler W. G., Poole-Wilson P. A., Williams A. Hypoxia and calcium. J Mol Cell Cardiol. 1979 Jul;11(7):683–706. doi: 10.1016/0022-2828(79)90381-x. [DOI] [PubMed] [Google Scholar]
  16. Nayler W. G., Yepez C. E., Fassold E., Ferrari R. Prolonged protective effect of propranolol on hypoxic heart muscle. Am J Cardiol. 1978 Aug;42(2):217–225. doi: 10.1016/0002-9149(78)90903-7. [DOI] [PubMed] [Google Scholar]
  17. Nayler W. G., Yepez C. E., Poole-Wilson P. A. The effect of beta-adrenoceptor and Ca2+ antagonist drugs on the hypoxia-induced increased in resting tension. Cardiovasc Res. 1978 Nov;12(11):666–674. doi: 10.1093/cvr/12.11.666. [DOI] [PubMed] [Google Scholar]
  18. Opie L. H., Mansford K. R., Owen P. Effects of increased heart work on glycolysis and adenine nucleotides in the perfused heart of normal and diabetic rats. Biochem J. 1971 Sep;124(3):475–490. doi: 10.1042/bj1240475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Parker J. O., Chiong M. A., West R. O., Case R. B. The effect of ischemia and alterations of heart rate on myocardial potassium balance in man. Circulation. 1970 Aug;42(2):205–217. doi: 10.1161/01.cir.42.2.205. [DOI] [PubMed] [Google Scholar]
  20. Peng C. F., Kane J. J., Murphy M. L., Straub K. D. Abnormal mitochondrial oxidative phosphorylation of ischemic myocardium reversed by Ca2+-chelating agents. J Mol Cell Cardiol. 1977 Nov;9(11):897–908. doi: 10.1016/s0022-2828(77)80010-2. [DOI] [PubMed] [Google Scholar]
  21. Shen A. C., Jennings R. B. Kinetics of calcium accumulation in acute myocardial ischemic injury. Am J Pathol. 1972 Jun;67(3):441–452. [PMC free article] [PubMed] [Google Scholar]
  22. Shen A. C., Jennings R. B. Myocardial calcium and magnesium in acute ischemic injury. Am J Pathol. 1972 Jun;67(3):417–440. [PMC free article] [PubMed] [Google Scholar]
  23. Shine K. I., Douglas A. M., Ricchiuti N. V. Calcium, strontium, and barium movements during ischemia and reperfusion in rabbit ventricle. Implications for myocardial preservation. Circ Res. 1978 Nov;43(5):712–720. doi: 10.1161/01.res.43.5.712. [DOI] [PubMed] [Google Scholar]
  24. Shine K. I., Douglas A. M., Ricchiuti N. Ischemia in isolated interventricular septa: mechanical events. Am J Physiol. 1976 Oct;231(4):1225–1232. doi: 10.1152/ajplegacy.1976.231.4.1225. [DOI] [PubMed] [Google Scholar]
  25. Sordahl L. A., McCollum W. B., Wood W. G., Schwartz A. Mitochondria and sarcoplasmic reticulum function in cardiac hypertrophy and failure. Am J Physiol. 1973 Mar;224(3):497–502. doi: 10.1152/ajplegacy.1973.224.3.497. [DOI] [PubMed] [Google Scholar]
  26. Tomlinson C. W., Dhalla N. S. Excitation-contraction coupling in heart. IX. Changes in the intracellular stores of calcium in failing hearts due to lack of substrate and oxygen. Cardiovasc Res. 1973 Jul;7(4):470–476. doi: 10.1093/cvr/7.4.470. [DOI] [PubMed] [Google Scholar]
  27. Zimmerman A. N., Hülsmann W. C. Paradoxical influence of calcium ions on the permeability of the cell membranes of the isolated rat heart. Nature. 1966 Aug 6;211(5049):646–647. doi: 10.1038/211646a0. [DOI] [PubMed] [Google Scholar]

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