Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1982 Aug;41(4):371–376. doi: 10.1136/ard.41.4.371

Pyrophosphate arthropathy: a clinical and radiological study of 105 cases.

P A Dieppe, G J Alexander, H E Jones, M Doherty, D G Scott, A Manhire, I Watt
PMCID: PMC1000953  PMID: 7114920

Abstract

105 consecutive patients who presented to a rheumatologist because of joint disease and who also had evidence of deposition of calcium pyrophosphate dihydrate (CPD) were studied clinically and radiologically. There were 76 women (mean age 73) and 29 men (mean age 62). Of only 18 patients below the age of 60 at presentation 12 were men. The majority of the younger male group suffered from acute attacks of synovitis, and had no clinical or radiological evidence of joint damage. In contrast the older female group had widespread destructive changes. Associated joint disease included generalised osteoarthritis (45), rheumatoid arthritis (8), joint hypermobility (13), previous knee surgery (8), and gout 92). Sixteen patients had received long-term steroid therapy. Severe destructive joint changes were seen in 16 patients. The radiological features in those with rheumatoid arthritis by ARA criteria were atypical. The relationship between CPD deposition and arthritis is discussed in the light of these findings.

Full text

PDF
371

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkins C. J., McIvor J., Smith P. M., Hamilton E., Williams R. Chondrocalcinosis and arthropathy: studies in haemochromatosis and in idiopathic chondrocalcinosis. Q J Med. 1970 Jan;39(153):71–82. [PubMed] [Google Scholar]
  2. Beighton P., Solomon L., Soskolne C. L. Articular mobility in an African population. Ann Rheum Dis. 1973 Sep;32(5):413–418. doi: 10.1136/ard.32.5.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bird H. A., Tribe C. R., Bacon P. A. Joint hypermobility leading to osteoarthrosis and chondrocalcinosis. Ann Rheum Dis. 1978 Jun;37(3):203–211. doi: 10.1136/ard.37.3.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Currey H. L., Key J. J., Mason R. M., Swettenham K. V. Significance of radiological calcification of joint cartilage. Ann Rheum Dis. 1966 Jul;25(4):295–306. doi: 10.1136/ard.25.4.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dieppe P. A., Crocker P. R., Corke C. F., Doyle D. V., Huskisson E. C., Willoughby D. A. Synovial fluid crystals. Q J Med. 1979 Oct;48(192):533–553. [PubMed] [Google Scholar]
  6. Ellman M. H., Levin B. Chondrocalcinosis in elderly persons. Arthritis Rheum. 1975 Jan-Feb;18(1):43–47. doi: 10.1002/art.1780180109. [DOI] [PubMed] [Google Scholar]
  7. Genant H. K. Roentgenographic aspects of calcium pyrophosphate dihydrate crystal deposition disease (pseudogout). Arthritis Rheum. 1976 May-Jun;19 (Suppl 3):307–328. doi: 10.1002/1529-0131(197605/06)19:3+<307::aid-art1780190705>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  8. Hamilton E. B. Diseases associated with CPPD deposition disease. Arthritis Rheum. 1976 May-Jun;19 (Suppl 3):353–357. doi: 10.1002/1529-0131(197605/06)19:3+<353::aid-art1780190708>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  9. Huskisson E. C., Balme H. W. Pseudopodagra. Differential diagnosis of gout. Lancet. 1972 Aug 5;2(7771):269–271. doi: 10.1016/s0140-6736(72)91699-6. [DOI] [PubMed] [Google Scholar]
  10. Huskisson E. C., Dieppe P. A., Tucker A. K., Cannell L. B. Another look at osteoarthritis. Ann Rheum Dis. 1979 Oct;38(5):423–428. doi: 10.1136/ard.38.5.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jacobelli S., McCarty D. J., Silcox D. C., Mall J. C. Calcium pyrophosphate dihydrate crystal deposition in neuropathic joints. Four cases of polyarticular involvement. Ann Intern Med. 1973 Sep;79(3):340–347. doi: 10.7326/0003-4819-79-3-340. [DOI] [PubMed] [Google Scholar]
  12. KOHN N. N., HUGHES R. E., McCARTY D. J., Jr, FAIRES J. S. The significance of calcium phosphate crystals in the synovial fluid of arthritic patients: the "pseudogout syndrome". II. Identification of crystals. Ann Intern Med. 1962 May;56:738–745. doi: 10.7326/0003-4819-56-5-738. [DOI] [PubMed] [Google Scholar]
  13. McCarty D. J. Calcium pyrophosphate dihydrate crystal deposition disease--1975. Arthritis Rheum. 1976 May-Jun;19 (Suppl 3):275–285. doi: 10.1002/1529-0131(197605/06)19:3+<275::aid-art1780190702>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  14. Menkes C. J., Simon F., Delrieu F., Forest M., Delbarre F. Destructive arthropathy in chondrocalcinosis articularis. Arthritis Rheum. 1976 May-Jun;19 (Suppl 3):329–348. doi: 10.1002/1529-0131(197605/06)19:3+<329::aid-art1780190706>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  15. Resnick D., Curd J., Shapiro R. F., Wiesner K. B. Radiographic abnormalities of rheumatoid arthritis in patients with diffuse idiopathic skeletal hyperostosis. Arthritis Rheum. 1978 Jan-Feb;21(1):1–5. doi: 10.1002/art.1780210101. [DOI] [PubMed] [Google Scholar]
  16. Resnick D., Niwayama G., Goergen T. G., Utsinger P. D., Shapiro R. F., Haselwood D. H., Wiesner K. B. Clinical, radiographic and pathologic abnormalities in calcium pyrophosphate dihydrate deposition disease (CPPD): pseudogout. Radiology. 1977 Jan;122(1):1–15. doi: 10.1148/122.1.1. [DOI] [PubMed] [Google Scholar]
  17. Richards A. J., Hamilton E. B. Destructive arthropathy in chondrocalcinosis articularis. Ann Rheum Dis. 1974 May;33(3):196–203. doi: 10.1136/ard.33.3.196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Silberberg R., Hasler M. Submicroscopic effects of hormones on articular cartilage of adult mice. Arch Pathol. 1971 Mar;91(3):241–255. [PubMed] [Google Scholar]
  19. Zitnan D., Sitaj S. Natural course of articular chondrocalcinosis. Arthritis Rheum. 1976 May-Jun;19 (Suppl 3):363–390. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES